FFR Versus IVUS with Angiography-Derived FFR for Clinical Outcomes in Patients with Coronary Artery Disease

NARecruitingINTERVENTIONAL
Enrollment

1,942

Participants

Timeline

Start Date

March 13, 2024

Primary Completion Date

December 1, 2027

Study Completion Date

December 1, 2029

Conditions
Coronary Artery Disease
Interventions
PROCEDURE

Intravascular ultrasound-guided stent implantation after angiography-derived FFR-based decision-making

"The percutaneous coronary intervention will be performed by intravascular ultrasound (IVUS)-guided strategy after angiography-derived FFR-based decision-making:~1. PCI will be performed if angiography-derived FFR ≤0.80 and will be deferred if angiography-derived FFR \>0.80.~2. If PCI is performed, PCI optimization using IVUS will be performed following the recommended criteria: ① Plaque burden at stent edge ≤55%; ② Minimal stent area ≥ 5.5 mm2, or minimal stent area ≥ distal reference lumen area"

PROCEDURE

Fractional flow reserve-guided PCI strategy

"The percutaneous coronary intervention will be performed by fractional flow reserve (FFR)-guided strategy:~1. PCI will be performed if FFR ≤0.80 and will be deferred if FFR \>0.80.~2. If PCI is performed, PCI optimization using FFR will be performed following the recommended criteria: ① Post-PCI FFR ≥ 0.88, or ② Post-PCI ΔFFR (\[FFR at stent distal edge\] - \[FFR at stent proximal edge\]) \< 0.05"

Trial Locations (25)

Unknown

RECRUITING

Peking University Third Hospital, Beijing

RECRUITING

Second Affiliated Hospital of Shantou University Medical College, Guangdong

RECRUITING

The Affiliated Hospital of Hangzhou Normal University, Hangzhou

NOT_YET_RECRUITING

The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou

RECRUITING

Changxing People's Hospital, Huzhou

NOT_YET_RECRUITING

The Affiliated Hospital of Shandong University of TCM, Jinan

RECRUITING

The Fourth People's Hospital of Jinan, Jinan

RECRUITING

Jinhua Central Hospital, Jinhua

NOT_YET_RECRUITING

First Affiliated Hospital of Kunming Medical University, Kunming

RECRUITING

The First Affiliated Hospital of Nanchang University, Nanchang

NOT_YET_RECRUITING

Ningbo Medical Center Lihuili Hospital, Ningbo

RECRUITING

The Affiliated Hospital of Medical College, Ningbo University, Ningbo

NOT_YET_RECRUITING

Renji Hospital Shanghai Jiaotong University School of Medicine, Shanghai

RECRUITING

The First Affiliated hospital of Wenzhou Medical University, Wenzhou

NOT_YET_RECRUITING

Bucheon Sejong Hospital, Bucheon-si

NOT_YET_RECRUITING

Inje University Haeundae Paik Hospital, Busan

NOT_YET_RECRUITING

Keimyung University Dongsan Medical Center, Daegu

NOT_YET_RECRUITING

Kyungpook National University Hospital, Daegu

NOT_YET_RECRUITING

Chonnam National University Hospital, Donggu

NOT_YET_RECRUITING

Inje University Ilsan Paik Hospital, Goyang

RECRUITING

Seoul National University Hospital,, Seoul

NOT_YET_RECRUITING

Seoul ST. Mary's Hospital, Seoul

NOT_YET_RECRUITING

Uijeongbu Eulji Medical Center, Uijeongbu-si

NOT_YET_RECRUITING

Ulsan University Hospital, Ulsan

NOT_YET_RECRUITING

Yonsei University Wonju Severance Hospital, Wŏnju

All Listed Sponsors
collaborator

Seoul National University Hospital

OTHER

collaborator

Peking University Third Hospital

OTHER

collaborator

RenJi Hospital

OTHER

collaborator

Second Affiliated Hospital of Shantou University Medical College

OTHER

collaborator

The First Affiliated Hospital of Nanchang University

OTHER

collaborator

First Affiliated Hospital of Kunming Medical University

OTHER

collaborator

The Fourth People's Hospital of Jinan

UNKNOWN

collaborator

Jinhua Central Hospital

OTHER

collaborator

The Affiliated Hospital of Hangzhou Normal University

OTHER

collaborator

Changxing People's Hospital

OTHER

collaborator

First Affiliated Hospital of Wenzhou Medical University

OTHER

collaborator

The Affiliated Hospital of Medical College, Ningbo University

OTHER

collaborator

Keimyung University Dongsan Medical Center

OTHER

collaborator

Inje University Ilsan Paik Hospital

OTHER

collaborator

Ulsan University Hospital

OTHER

collaborator

Uijeongbu Eulji Medical Center

UNKNOWN

collaborator

Kyungpook National University Hospital

OTHER

collaborator

Seoul St. Mary's Hospital

OTHER

collaborator

Yonsei University Wonju Severance Hospital

UNKNOWN

collaborator

Inje University Haeundae Paik Hospital

OTHER

collaborator

Sejong General Hospital

OTHER

collaborator

Chonnam National University Hospital

OTHER

collaborator

Ningbo Medical Center Lihuili Hospital

OTHER_GOV

collaborator

The Affiliated Hospital of Shandong University of TCM

UNKNOWN

lead

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER