Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder (ASD) Using Transcranial Magnetic Stimulation (TMS)

NARecruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

April 3, 2024

Primary Completion Date

October 31, 2027

Study Completion Date

October 31, 2027

Conditions
Autism Spectrum Disorder
Interventions
DIAGNOSTIC_TEST

fMRI

fMRI will be performed pre- and post-rTMS

DEVICE

rTMS

TMS procedures are scheduled during study sessions 2-4 between the two MRI scans on those days. Because rTMS induces neural changes that last about 1 hour, rTMS will be applied immediately before the second MRI scan on each day. Prior to the TMS visits, target coordinates and orientation vectors will be generated from the MRI data and the e-field models and loaded into Localite along with the participant's reconstructed T1 image. During the visits, the participant's head will be co-registered to the T1 using fiducial points at the Nasion and Tragi. TMS pulses will be delivered, using the Localite software to target and track the optimal orientation calculated with e-field modeling.

Trial Locations (1)

06106

RECRUITING

Olin Neuropsychiatry Research Center (ONRC), Hartford

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

Yale University

OTHER