80
Participants
Start Date
April 3, 2024
Primary Completion Date
October 31, 2027
Study Completion Date
October 31, 2027
fMRI
fMRI will be performed pre- and post-rTMS
rTMS
TMS procedures are scheduled during study sessions 2-4 between the two MRI scans on those days. Because rTMS induces neural changes that last about 1 hour, rTMS will be applied immediately before the second MRI scan on each day. Prior to the TMS visits, target coordinates and orientation vectors will be generated from the MRI data and the e-field models and loaded into Localite along with the participant's reconstructed T1 image. During the visits, the participant's head will be co-registered to the T1 using fiducial points at the Nasion and Tragi. TMS pulses will be delivered, using the Localite software to target and track the optimal orientation calculated with e-field modeling.
RECRUITING
Olin Neuropsychiatry Research Center (ONRC), Hartford
National Institute of Mental Health (NIMH)
NIH
Yale University
OTHER