Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

563

Participants

Timeline

Start Date

June 5, 2024

Primary Completion Date

July 5, 2027

Study Completion Date

September 30, 2028

Conditions
Extensive-Stage Small-Cell Lung CancerSmall-Cell Lung Cancer
Interventions
DRUG

Tarlatamab

Intravenous (IV) infusion

DRUG

Durvalumab

IV infusion

Trial Locations (219)

9

Beaumont Hospital, Dublin

1083

Semmelweis Egyetem, Budapest

1090

Universitair Ziekenhuis Brussel, Brussels

1121

Orszagos Koranyi Pulmonologiai Intezet, Budapest

1200

Universite Catholique de Louvain Cliniques Universitaires Saint Luc, Brussels

2045

Reformatus Pulmonologiai Centrum, Törökbálint

2050

Chris OBrien Lifehouse, Camperdown

2100

Rigshospitalet, Copenhagen

2500

Wollongong Hospital, Wollongong

2650

Universitair Ziekenhuis Antwerpen, Edegem

3010

Inselspital Bern, Bern

3168

Monash Medical Centre, Clayton

3200

Matrai Gyogyintezet, Gyöngyös

3500

Universitaetsklinikum Krems, Krems

3600

Ziekenhuis Oost-Limburg, Genk

4000

Exelsus Oncologia Clinica, San Miguel de Tucumán

4052

Universitaetsspital Basel, Basel

4120

Greenslopes Private Hospital, Greenslopes

5000

Cancer Research South Australia, Adelaide

Odense Universitetshospital, Odense C

5530

Centre Hospitalier Universitaire-Universite Catholique de Louvain Namur-Site Godinne, Yvoir

6009

Sir Charles Gairdner Hospital, Nedlands

6830

Landeskrankenhaus Feldkirch, Rankweil

6850

Ospedale Regionale di Bellinzona e Vali, Mendrisio

7000

Centres Hospitaliers Universitaires - Helora - Hopital de Mons - Site Kennedy, Mons

7400

Regionshospitalet Godstrup, Herning

8000

Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz, Székesfehérvár

8036

Medizinische Universitaet Graz, Graz

8324

Fundacion Medica de Rio Negro y Neuquen, Cipolletti

9000

Algemeen Ziekenhuis Maria Middelares, Ghent

9007

Kantonsspital Sankt Gallen, Sankt Gallen

9024

Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktatokorhaz, Győr

9300

Azorg Campus Aalst - Moorselbaan, Aalst

10002

National Taiwan University Hospital, Taipei

10408

National Cancer Center, Goyang-si Gyeonggi-do

10461

Montefiore Medical Center - Bronx, The Bronx

11217

Taipei Veterans General Hospital, Taipei

11526

Henry Dunant Hospital Center, Athens

11527

Sotiria General Hospital, Athens

12462

Attikon University Hospital, Athens

13620

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do

13915

Centre Hospitalier Universitaire Nord, Marseille

15212

Allegheny Health Network, Pittsburgh

15232

University of Pittsburgh Medical Center, Pittsburgh

15562

Metropolitan General, Athens

18547

Metropolitan Hospital, Athens

20141

IRCCS Istituto Oncologico Europeo, Milan

20162

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan

22927

LungenClinic Grosshansdorf GmbH, Großhansdorf

23298

Virginia Commonwealth University Massey Cancer Center, Richmond

23606

Virginia Oncology Associates, Newport News

27157

Wake Forest University Health Sciences, Winston-Salem

27710

Duke University, Durham

28034

Hospital Universitario Ramon y Cajal, Madrid

28644

Chungbuk National University Hospital, Cheongju Chungbuk

29011

Hospital Regional Universitario de Malaga, Málaga

29200

Centre Hospitalier Regional Universitaire de Brest - Hopital Morvan, Brest

29425

Medical University of South Carolina, Charleston

30322

Emory University, Atlanta

30501

Northeast Georgia Medical Center, Gainesville

30607

University Cancer and Blood Center LLC, Athens

31008

Clinica Universidad de Navarra, Pamplona

31059

Centre Hospitalier Universitaire de Toulouse - Hopital Larrey, Toulouse

33000

Institut Bergonie, Bordeaux

33200

Medical Park Seyhan Hastanesi, Mersin

VM Medical Park Mersin Hastanesi, Mersin

34214

Bagcilar Medipol Mega Universite Hastanesi, Istanbul

34298

Institut regional du Cancer Montpellier, Montpellier

35150

Izmir Katip Celebi Universitesi Ataturk Egitim ve Arastirma Hastanesi, Izmir

36607

Infirmary Cancer Center, Mobile

37126

Centro Ricerche Cliniche Di Verona Societa responsabilita limitata, Verona

37203

Sarah Cannon Research Institute, Nashville

38120

Baptist Cancer Center Memphis Thoracic, Memphis

41009

Hospital Universitario Virgen Macarena, Seville

43210

The Ohio State University, Columbus

44106

University Hospitals Cleveland Medical Center, Cleveland

44800

Centre Hospitalier Universitaire de Nantes - Hopital Nord Laennec, Saint-Herblain

45147

Universitaetsklinikum Essen, Essen

45242

Oncology Hematology Care Incorporated, Cincinnati

46026

Hospital Universitari i Politecnic La Fe, Valencia

46237

Franciscan Health Indianapolis, Indianapolis

48149

University Hospital Muenster, Münster

49503

Cancer and Hematology Centers of Western Michigan, Grand Rapids

51109

Kliniken der Stadt Koeln gGmbH, Cologne

53226

The Medical College of Wisconsin, Milwaukee

54290

Sakarya Egitim ve Arastirma Hastanesi, Sakarya

55102

Allina Health System dba Allina Health Cancer Institute, Saint Paul

55236

Saint Lukes Hospital SA, Thessaloniki

55905

Mayo Clinic, Rochester

57001

European Interbalkan Medical Center, Thessaloniki

59300

Clinique Teissier, Valenciennes

60612

University of Illinois Chicago, Chicago

65807

Oncology Hematology Associates, Springfield

67091

Centre Hospitalier Universitaire de Strasbourg - Nouvel Hopital Civil, Strasbourg

68130

Nebraska Cancer Specialists, Omaha

69008

Centre Leon Berard, Lyon

69126

Universitaetsklinikum Heidelberg, Heidelberg

70124

IRCCS Istituto Tumori Giovanni Paolo II, Bari

70403

National Cheng Kung University Hospital, Tainan City

70808

Our Lady of the Lake Cancer Institute, Baton Rouge

72000

Centre Hospitalier - Le Mans, Le Mans

75014

Hopital Cochin, Paris

75246

Texas Oncology - Dallas Fort Worth, Dallas

US Oncology Research Investigational Products Center, Dallas

77030

University of Texas MD Anderson Cancer Center, Houston

82130

Asklepios Fachkliniken Muenchen Gauting, Gauting

83301

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

90033

University of Southern California, Los Angeles

94010

Centre Hospitalier Intercommunal de Creteil, Créteil

97078

Universitaetsklinikum Wuerzburg, Würzburg

97239

Oregon Health and Science University, Portland

97401

Oncology Associates of Oregon, PC, Eugene

98104

Swedish Cancer Institute, Seattle

100020

Beijing Chaoyang Hospital, Capital Medical University, Beijing

100142

Beijing Cancer Hospital, Beijing

Beijing Cancer Hospital, Beijing

100337

Spitalul Municipal Ploiesti, Ploieşti

130012

Jilin Cancer Hospital, Changchun

154007

Jiamusi Cancer Hospital, Jiamusi

200030

Shanghai Chest Hospital, Shanghai

200433

Shanghai Pulmonary Hospital, Shanghai

210029

Nanjing Chest Hospital, Nanjing

221009

Xuzhou Central Hospital, Xuzhou

250117

The Affiliated Cancer Hospital of Shandong First Medical University, Jinan

276000

Linyi Cancer Hospital, Linyi

300121

Tianjin Peoples Hospital, Tianjin

310003

the First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou

315010

The First Affiliated Hospital Of Ningbo University, Ningbo

325015

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

330029

Jiangxi Cancer hospital, Nanchang

350014

Fujian Cancer Hospital, Fuzhou

362002

The Second Attached Hospital Of Fujian Medical University, Quanzhou

400015

Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca, Cluj-Napoca

400037

Xinqiao Hospital, Chongqing

430070

Hubei Cancer Hospital, Wuhan

450003

Henan Cancer Hospital, Zhengzhou

450066

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

510060

Sun Yat-sen University Cancer Center, Guangzhou

530201

Guangxi Medical University Affiliated Tumor Hospital, Nanning

541001

Affiliated Hospital of Guilin Medical University, Guilin

611135

West China Hospital of Sichuan University, Chengdu

710065

The First Affiliated Hospital of Xian Jiaotong University, Xi’an

830054

Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi

3109601

Rambam Medical Center, Haifa

4428164

Meir Medical Center, Kfar Saba

4941492

Rabin Medical Center, Petah Tikva

9103102

Shaare Zedek Medical Center, Jerusalem

06510

Yale New Haven Hospital, New Haven

02215

Dana-Farber Cancer Institute, Boston

08816

Astera Cancer Care, East Brunswick

08901

Rutgers Cancer Institute of New Jersey, New Brunswick

C1280AEB

Hospital Britanico de Buenos Aires, CABA

C1426ANZ

Instituto Alexander Fleming, Capital Federal

F5300COE

Fundacion Centro Oncológico Riojano Integral para la Investigación y Prevención del Cáncer, La Rioja

B-1070

Institut Jules Bordet, Brussels

40170-110

Hospital Sao Rafael-Idor, Salvador

30130-090

Cenantron Centro Avançado de Tratamento Oncologico Ltda, Belo Horizonte

37904-020

Santa Casa de Misericordia de Passos, Passos

85806-300

Hospital Uopeccan, Cascavel

98700-000

Hospital de Clinicas de Ijui, Ijuí

99010-260

Hospital de Clinicas de Passo Fundo, Passo Fundo

90020-090

Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre

01509-900

Fundacao Antonio Prudente AC Camargo Cancer Center, São Paulo

05652-900

Hospital Israelita Albert Einstein, São Paulo

22250-905

Oncoclinicas Rio de Janeiro S A, Rio de Janeiro

N6A 5W9

London Health Sciences Centre, London

G1R 2J6

CHU de Quebec Hopital de l Enfant Jesus, Québec

061011

Cangzhou Peoples Hospital, Cangzhou

010010

The Affiliated Hospital of Inner Mongolia Medical University, Hohhot

030009

Shanxi Provincial Cancer Hospital, Taiyuan

625 00

Fakultni nemocnice Brno, Brno

779 00

Fakultni nemocnice Olomouc, Olomouc

703 00

Nemocnice Agel Ostrava-Vitkovice as, Ostrava-Vitkovice

128 08

Vseobecna fakultni nemocnice v Praze, Prague

150 06

Fakultni nemocnice v Motole, Prague

01307

Universitaetsklinikum Dresden, Dresden

Unknown

Princess Margaret Hospital, Kowloon

Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories

464-8681

Aichi Cancer Center, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa-shi

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

812-8582

Kyushu University Hospital, Fukuoka

830-0011

Kurume University Hospital, Kurume-shi

003-0804

National Hospital Organization Hokkaido Cancer Center, Sapporo

673-8558

Hyogo Cancer Center, Akashi-shi

241-8515

Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center, Yokohama

951-8566

Niigata Cancer Center Hospital, Niigata

700-8558

Okayama University Hospital, Okayama

573-1191

Kansai Medical University Hospital, Hirakata-shi

541-8567

Osaka International Cancer Institute, Osaka

589-8511

Kindai University Hospital, Osakasayama-shi

350-1298

Saitama Medical University International Medical Center, Hidaka-shi

411-8777

Shizuoka Cancer Center, Sunto-gun

113-8431

Juntendo University Hospital, Bunkyo-ku

104-0045

National Cancer Center Hospital, Chuo-ku

135-8550

The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku

641-8510

Wakayama Medical University Hospital, Wakayama

03100

Health Pharma Professional Research SA de CV, Mexico City

03810

Oncare, Mexico City

9713 GZ

Universitair Medisch Centrum Groningen, Groningen

6229 HX

Maastricht Universitair Medisch Centrum, Maastricht

3015 GD

Erasmus Medisch Centrum, Rotterdam

80-214

Uniwersyteckie Centrum Kliniczne, Gdansk

60-569

Wielkopolskie Centrum Pulmonologii i Torakochirurgii imienia Eugenii i Janusza Zeylandow, Poznan

01-138

Instytut Gruzlicy i Chorob Pluc, Warsaw

53-439

Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii, Wroclaw

1500-650

Hospital da Luz, SA, Lisbon

1998-018

Hospital Cuf Descobertas, Lisbon

4464-513

Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano, Matosinhos Municipality

4100-180

Hospital Cuf porto, Porto

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08035

Hospital Universitari Vall d Hebron, Barcelona

08036

Hospital Clinic i Provincial de Barcelona, Barcelona

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

08908

Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals, L'Hospitalet de Llobregat

06800

Ankara Bilkent Sehir Hastanesi, Ankara

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY