Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

82

Participants

Timeline

Start Date

July 10, 2024

Primary Completion Date

December 31, 2030

Study Completion Date

December 31, 2035

Conditions
Childhood CancerChildhood Solid TumorChildhood Brain TumorRecurrent CancerRefractory Cancer
Interventions
DRUG

Paxalisib, Irinotecan, Temozolomide

Irinotecan 50mg/m2/day, intravenous, on days 1-5, 28 day cycle, 13 cycles Temozolomide 150mg/m2/day, oral, on days 1-5, 28 day cycle, 13 cycles Paxalisib 21mg/m2 oral, daily, 28 day cycle, 13 cycles

Trial Locations (11)

Unknown

NOT_YET_RECRUITING

John Hunter Children's Hospital, Newcastle

RECRUITING

Sydney Children's Hospital, Randwick, Sydney

NOT_YET_RECRUITING

The Children's Hospital at Westmead, Sydney

RECRUITING

Queensland Children's Hospital, Brisbane

NOT_YET_RECRUITING

Women's and Children's Hospital, Adelaide

RECRUITING

Monash Children's Hospital, Melbourne

RECRUITING

Royal Children's Hospital, Melbourne

RECRUITING

Perth Children's Hospital, Perth

NOT_YET_RECRUITING

CHU Sainte Justine, Montreal

NOT_YET_RECRUITING

The Hospital for Sick Children, Toronto

NOT_YET_RECRUITING

BC Children's Hospital, Vancouver

All Listed Sponsors
collaborator

Children's Cancer Institute Australia (CCIA)

UNKNOWN

collaborator

The Hospital for Sick Children

OTHER

collaborator

Medical Research Future Fund

OTHER

collaborator

Kazia Therapeutics Limited

INDUSTRY

collaborator

C17 Council

OTHER

lead

Australian & New Zealand Children's Haematology/Oncology Group

OTHER