Localized Treatment Versus Palliative Chemotherapy in CRC Patients With 10 or More CRLM

Participants may receive surgical resection and/or ablation therapy and/or stereotactic body radiotherapy

Participants in this group may continue the original systemic chemotherapy regimen. Patients with tumor control after 10-12 cycles can either transition to maintenance treatment or temporarily suspend treatment until disease progression, at which point they switch to a second-line treatment regimen.The selection of second-line and subsequent treatment regimens follows CSCO guidelines and clinical practices.