600
Participants
Start Date
August 1, 2023
Primary Completion Date
January 31, 2027
Study Completion Date
July 31, 2027
Feed back controlled temperature device
If core temperature exceeds 37.7 degrees celsius a feedback controlled-device will be used at set to 37.5 degrees celsius
High MAP
A mean arterial blood pressure (MAP) of \>85mmHg will be used. Vasopressors will be titrated to this target during 36 hours
Deep sedation
Deep sedation for at least 36 hours
Fever control without a device
Management of fever in the intensive care unit without a device
Low MAP
A mean arterial blood pressure (MAP) of \>65mmHG will be used. Vasopressors will be titrated to this target during 36 hours
Minimal sedation
A strategy of minimal sedation in the intensive care unit, used only as needed to facilitate transport, imaging and invasive procedures
RECRUITING
Princess Alexandra Hospital, Brisbane
RECRUITING
The Sutherland Hospital, Caringbah
RECRUITING
The Prince Charles Hospital, Chermside
RECRUITING
Nepean hospital, Kingswood
RECRUITING
St George hospital, Kogarah
RECRUITING
Liverpool hospital, Liverpool
RECRUITING
Austin hospital, Melbourne
RECRUITING
Royal North Shore Hospital, Sydney
RECRUITING
Ziekenhuis Oost Limburg, Genk
RECRUITING
Ghent university hospital, Ghent
RECRUITING
Helsinki Helsingfors university central hospital, Helsinki
RECRUITING
Jorvi hospital, Jorvi
RECRUITING
Tampere university hospital, Tampere
RECRUITING
Charite university hospital, Berlin
RECRUITING
Universitäres Herzzentrum Lübeck Universitätsklinikum Schleswig-Holstein, Lübeck
RECRUITING
Tubingen university hospital, Tübingen
RECRUITING
Centre Hospitalier de Luxembourg, Luxembourg
RECRUITING
Auckland city hospital, Auckland
RECRUITING
Middlemore hospital, Auckland
RECRUITING
Christchurch hospital, Christchurch
RECRUITING
Wellington hospital, Wellington
RECRUITING
Sorlandet hospital, Arendal
RECRUITING
Oslo university hospital Rikshospitalet, Oslo
RECRUITING
Sahlgrenska university hospital, Gothenburg
RECRUITING
Hallands hospital, Hålland
RECRUITING
Helsingborg hospital, Helsingborg
RECRUITING
Skåne university hospital, Lund
RECRUITING
Skåne university hopsital, Malmo
RECRUITING
Bern university hospital, Bern
RECRUITING
Kantonsspital St. Gallen, Sankt Gallen
RECRUITING
The Essex Cardiothoracic Centre, Basildon
RECRUITING
Bristol Royal Infirmary, Bristol
RECRUITING
University hospital of Wales, Cardiff
RECRUITING
St Bartholomew's hospital, London
Lund University
OTHER
The George Institute for Global Health, Australia
OTHER
Copenhagen Trial Unit, Center for Clinical Intervention Research
OTHER
Helsinki University Central Hospital
OTHER
Region Skane
OTHER