NCT06205927View on ClinicalTrials.gov

Randomized Study of Carbon Ion Boost in Hypoxic Lesions for Locally Advanced Non-small Cell Lung Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

77

Participants

Timeline

Start Date

December 7, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2026

Conditions
Non-small Cell Lung Cancer
Interventions
RADIATION

Standard carbon ion beam radiotherapy

The standard treatment arm will receive carbon ion beam radiotherapy of 77Gy (RBE equivalent) per 22 fractions for gross tumor volume.

RADIATION

Carbon ion beam radiotherapy simultaneously dose boost

The hypoxic lesions dose boost arm will receive 77Gy (RBE equivalent) per 22 fractions for gross tumor volume and a simultaneously dose boost of 83.6Gy (RBE equivalent) per 22 fractions for hypoxic lesions detected by 18F-Misonidazole PET/CT.

Trial Locations (1)

201513

RECRUITING

Shanghai Proton and Heavy Ion Center, Shanghai

Sponsors

Lead Sponsor

Jian Chen
All Listed Sponsors
lead

Jian Chen

OTHER

NCT06205927 - Randomized Study of Carbon Ion Boost in Hypoxic Lesions for Locally Advanced Non-small Cell Lung Cancer | Biotech Hunter | Biotech Hunter