High Versus Low Dose Serratus Anterior Plane Block After Minimally Invasive Valve Surgery.

NARecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

February 21, 2024

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
AnalgesiaSurgeryCardiac DiseasePost Operative Pain
Interventions
PROCEDURE

High dose serratus anterior plane block (2.4 mg/kg patient ideal body weight)

The needle will be introduced in-plane from supero-anterior to postero-inferior until the needle tip is positioned in the plane underneath the serratus muscle (deep compartment). Under continuous ultrasound guidance, 3/4th of the bupivacaine 0.25% plus epinephrine solution will be injected in the deep compartment. After the deep component of the serratus anterior plane block is completed, the needle will be withdrawn to the subcutaneous tissues. The needle will be flattened and advanced in-plane to the plane superficial to the serratus muscles. The remainder quarter of the bupivacaine 0.25% plus epinephrine solution will be injected superficial to the serratus muscles after correct placement of the needle tip is confirmed on ultrasound. In total a dose of 2.4mg/kg patient ideal body weight will be administered. There is a maximal dose of 200 mg adrenalized bupivacaine for patients with an ideal body weight of 83 kg or more.

PROCEDURE

Low dose serratus anterior plane block (1.2mg/kg patient ideal body weight)

The needle will be introduced in-plane from supero-anterior to postero-inferior until the needle tip is positioned in the plane underneath the serratus muscle (deep compartment). Under continuous ultrasound guidance, 3/4th of the bupivacaine 0.25% will be injected in the deep compartment. After the deep component of the serratus anterior plane block is completed, the needle will be withdrawn to the subcutaneous tissues. The needle will be flattened and advanced in-plane to the plane superficial to the serratus muscles. The remainder quarter of the bupivacaine 0.25% will be injected superficial to the serratus muscles after correct placement of the needle tip is confirmed on ultrasound.

DRUG

PCIA with morphine

A patient controlled intravenous analgesia system (Bodyguard 595 Colorvision®) with morphine (Sterop®) using following settings: bolus 1.5 mg and lockout interval 7 min with maximal dose of 30mg per 4 hours.

Trial Locations (1)

3500

RECRUITING

Jessa hospital, Hasselt

All Listed Sponsors
lead

Jessa Hospital

OTHER