A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

540

Participants

Timeline

Start Date

May 21, 2024

Primary Completion Date

April 30, 2027

Study Completion Date

February 22, 2029

Conditions
Small Cell Lung Cancer
Interventions
DRUG

Ifinatamab deruxtecan

12 mg/kg intravenous dose on Day 1 of each 21-day cycle

DRUG

Topotecan

Topotecan will be administered per local SoC.

DRUG

Amrubicin

Amrubicin will be administered per local SoC.

DRUG

Lurbinectedin

Lurbinectedin will be administered per local SoC

Trial Locations (230)

333

RECRUITING

Chang Gung Memorial Hospital, Taoyuan

1088

NOT_YET_RECRUITING

Semmelweis Egyetem, Budapest

1121

RECRUITING

Orszagos Koranyi Pulmonologiai Intezet, Budapest

1122

NOT_YET_RECRUITING

Orszagos Onkologiai Intezet, Budapest

1140

NOT_YET_RECRUITING

Wiener Gesundheitsverband Klinik Penzing, Vienna

1200

NOT_YET_RECRUITING

Cliniques Universitaires Saint-Luc, Brussels

1210

NOT_YET_RECRUITING

Klinik Floridsdorf, Vienna

1752

RECRUITING

Hfr Fribourg/Kantonsspital Fribourg, Villars-sur-Glâne

2050

RECRUITING

Chris O Brien Lifehouse, Camperdown

2650

NOT_YET_RECRUITING

UZA, Edegem

3010

RECRUITING

Inselspital - Universitaetsspital Bern, Bern

3021

RECRUITING

Sunshine Hospital, St Albans

3040

NOT_YET_RECRUITING

Centro Hospitalar E Universită Rio de Coimbra E.P.E., Coimbra

3080

RECRUITING

Seoul National University Hospital, Seoul

3350

RECRUITING

Ballarat Base Hospital, Ballarat

3500

NOT_YET_RECRUITING

Landesklinikum Krems, Krems

RECRUITING

Jessa Ziekenhuis Hospital, Hasselt

4000

RECRUITING

Centre Hospitalier Universitaire de Liege, Liège

4020

NOT_YET_RECRUITING

Kepler University Hospital, Linz

4102

RECRUITING

Princess Alexandra Hospital, Woolloongabba

4814

RECRUITING

Townsville Cancer Centre, Townsville

5042

RECRUITING

Flinders Medical Centre (Fmc), Bedford Park

5505

RECRUITING

Asan Medical Center, Seoul

5530

RECRUITING

Chu Ucl Namur, Yvoir

6000

RECRUITING

Bács-Kiskun Vármegyei Oktatókórház, Kecskemét

6008

RECRUITING

St John of God Subiaco Hospital, Subiaco

6800

NOT_YET_RECRUITING

Landeskrankenhaus Feldkirch, Feldkirch

RECRUITING

Ankara Bilkent City Hospital, Ankara

7548

RECRUITING

Srh Wald-Klinikum Gera Gmbh, Gera

8025

RECRUITING

Hospital de La Santa Creu I Sant Pau, Barcelona

8035

RECRUITING

Hospital Universitari Vall D'Hebron, Barcelona

8800

NOT_YET_RECRUITING

AZ DELTA, Roeselare

9007

RECRUITING

Kantonsspital St. Gallen, Sankt Gallen

9024

RECRUITING

Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz, Győr

10016

RECRUITING

New York University Cancer Center - Laura and Isaac, New York

10048

RECRUITING

National Taiwan University Cancer Centre, Taipei

10461

NOT_YET_RECRUITING

Montefiore Medical Center Prime, The Bronx

11042

RECRUITING

Clinical Research Alliance, Inc, Lake Success

11217

RECRUITING

Taipei Veterans General Hospital, Taipei

11408

RECRUITING

Hospital de Especialidades de Jerez de La Frontera, Jerez de la Frontera

11526

NOT_YET_RECRUITING

'Henry Dynant' Hospital Center, Athens

11527

NOT_YET_RECRUITING

General Hospital of Athens of Chest Diseases 'Sotiria', Athens

11528

NOT_YET_RECRUITING

General Hospital of Athens Alexandra, Athens

13005

RECRUITING

"Assistance Publique-HăPitaux de Marseille", Marseille

13125

RECRUITING

Evangelische Lungenklinik Berlin, Berlin

13620

RECRUITING

Seoul National University Bundang Hospital, Seongnam-si

14004

RECRUITING

Hospital Universitario Reina Sofia, Córdoba

16132

RECRUITING

Istituto Nazionale Per La Ricerca Sul Cancro Di Genova, Genova

16247

RECRUITING

The Catholic University of Korea, St. Vincent'S Hospital, Suwon

16499

RECRUITING

Ajou University Hospital, Suwon

20089

RECRUITING

Istituto Clinico Humanitas, Rozzano

20132

NOT_YET_RECRUITING

Ospedale San Raffaele, Milan

20133

RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20141

RECRUITING

IEO Istituto Europeo di Oncologia, Milan

20900

NOT_YET_RECRUITING

Azienda Socio Sanitaria Territoriale Di Monza (Presidio San Gerardo), Monza

21075

NOT_YET_RECRUITING

Asklepios Klinik Harburg, Hamburg

21080

RECRUITING

Dicle University, Medical Faculty, Diyarbakır

21201

RECRUITING

University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore

21287

NOT_YET_RECRUITING

John Hopkins School of Medicine, Baltimore

23007

NOT_YET_RECRUITING

Hospital Universitario Ciudad de Jaen, Jaén

24116

NOT_YET_RECRUITING

Staedtisches Krankenhaus Kiel, Kiel

24125

RECRUITING

Humanitas Gavazzeni, Bergamo

25124

NOT_YET_RECRUITING

Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia (Presidio Spedali Civili), Brescia

26121

NOT_YET_RECRUITING

Pius-Hospital Oldenburg, Oldenburg

26335

NOT_YET_RECRUITING

General Hospital of Patra Agios Andreas, Pátrai

28007

RECRUITING

Hospital General Universitario Gregorio Marañon, Madrid

28034

RECRUITING

Hospital Universitario Ramon Y Cajal, Madrid

28040

RECRUITING

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28041

RECRUITING

Hospital Universitario 12 de Octubre, Madrid

28046

RECRUITING

Hospital Universitario La Paz, Madrid

28644

RECRUITING

Chungbuk National University Hospital, Cheongju-si

29010

RECRUITING

Hospital Regional Universitario de Malaga, Málaga

32429

NOT_YET_RECRUITING

Johannes Wesling Klinikum Minden, Minden

32804

RECRUITING

AdventHealth Orlando, Cancer Institute, Orlando

33075

NOT_YET_RECRUITING

Chu Bordeaux, Bordeaux

33136

RECRUITING

University of Miami Hospital and Clinics Sylvester Comprehensive Cancer Center, Miami

33612

NOT_YET_RECRUITING

H. Lee Moffitt Cancer Center and Research Institute, Inc, Tampa

34093

RECRUITING

Goztepe Prof Dr Suleyman Yalcin City Hospital, Istanbul

34098

NOT_YET_RECRUITING

Istanbul University Cerrahpasa - Cerrahpasa Medical Faculty, Istanbul

34214

NOT_YET_RECRUITING

Medipol University Medical Faculty, Istanbul

34295

RECRUITING

Hopital Arnaud de Villeneuve, Montpellier

34298

RECRUITING

Institut Régional Du Cancer de Montpellier, Montpellier

34376

RECRUITING

Lki Lungenfachklinik Immenhausen, Immenhausen

35016

RECRUITING

Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria

35033

RECRUITING

Chu Rennes - Hopital Pontchaillou, Rennes

35392

RECRUITING

UNIVERSITATSKLINIKUM GIeBEN UND MARBURG GMBH, Giessen

35530

NOT_YET_RECRUITING

Izmir Medicalpark Hospital, Izmir

37134

RECRUITING

Centro Ricerche Cliniche Di Verona S.R.L., Verona

38138

RECRUITING

THE WEST CLINIC, PLLC dba West Cancer Center, Germantown

40503

RECRUITING

Baptist Health Lexington, Lexington

40705

RECRUITING

Taichung Veterans General Hospital, Taichung

41009

RECRUITING

Hospital Universitario Virgen Macarena, Seville

41013

RECRUITING

Hospital Universitario Virgen Del Rocio, Seville

41014

RECRUITING

Hospital Universitario Nuestra Señora de Valme, Seville

41110

NOT_YET_RECRUITING

University General Hospital of Larissa, Larissa

41404

RECRUITING

Kyungpook National University Chilgok Hospital, Daegu

42270

RECRUITING

Institut de Cancerologie de La Loire, Saint-Priest-en-Jarez

43100

RECRUITING

Azienda Ospedaliero Universitaria Di Parma, Parma

44708

RECRUITING

Cleveland Clinic Mercy Hospital, Canton

44805

NOT_YET_RECRUITING

"Chu Nantes - HăPital Guillaume Et Renă Laă<Nnec", Saint-Herblain

45122

RECRUITING

Universtitaetsklinikum Essen, Essen

45236

RECRUITING

Oncology/Hematology Care Clinical Trials, Llc, Cincinnati

48202

NOT_YET_RECRUITING

Henry Ford Health System, Detroit

53226

NOT_YET_RECRUITING

Medical College of Wisconsin, Milwaukee

55236

NOT_YET_RECRUITING

St Luke'S Hospital, Thessaloniki

60488

RECRUITING

Krankenhaus Nordwest Gmbh, Frankfurt

60590

RECRUITING

Universitaetsklinikum Frankfurt Goethe-Universitaet, Frankfurt am Main

60612

NOT_YET_RECRUITING

Rush University Medical Center, Chicago

63128

RECRUITING

Mercy Clinic Oncology and Hematology Sindelar Cancer Center, St Louis

68100

RECRUITING

"Ch de Mulhouse - HăPital Emile Muller", Mulhouse

69008

NOT_YET_RECRUITING

Centre Léon Bérard, Lyon

69037

RECRUITING

Institut Cœur Poumon CHU de Lille, Lille

70124

RECRUITING

Istituto Tumori Giovanni Paolo Ii Irccs Ospedale Oncologico Bari, Bari

70403

RECRUITING

National Cheng Kung University Hospitalx, Tainan City

72762

RECRUITING

Highlands Oncology Group, Springdale

75005

NOT_YET_RECRUITING

Institut Curie - Site de Paris, Paris

75020

RECRUITING

Hopital Tenon, Paris

75702

RECRUITING

Texas Oncology, P.A. - Tyler, Tyler

77030

RECRUITING

Houston Methodist Cancer Center, Houston

RECRUITING

University of Texas Md Anderson Cancer Center, Houston

77900

NOT_YET_RECRUITING

Fakultni Nemocnice Olomouc, Olomouc

80131

RECRUITING

Azienda Ospedaliera Universitaria- Universită Degli Studi Della Campania  Luigi Vanvitelliâ, Napoli

80756

RECRUITING

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

82131

RECRUITING

Asklepios Fachkliniken Muenchen-Gauting, Gauting

84000

RECRUITING

Institut Sainte Catherine, Avignon

87042

RECRUITING

Chu Limoges - Hopital Du Cluzeau, Limoges

88100

RECRUITING

Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro

89081

NOT_YET_RECRUITING

Universitaetsklinikum Ulm, Ulm

90095

RECRUITING

UCLA Hematology-Oncology, Los Angeles

92151

NOT_YET_RECRUITING

"HăPital Foch", Suresnes

92835

RECRUITING

Clinical Research Providence Medical Foundation, Fullerton

94010

RECRUITING

Centre Hospitalier Intercommunal de Cră Teil, Créteil

94115

RECRUITING

UCSF Mission Bay Mission Hall, San Francisco

94805

NOT_YET_RECRUITING

Institut Gustave Roussy, Villejuif

95123

NOT_YET_RECRUITING

Azienda Ospedaliera Universitaria Policlinico - Vittorio Emanuele (Presidio Gaspare Rodolico), Catania

97213

NOT_YET_RECRUITING

Providence Portland Medical Center, Portland

99089

RECRUITING

Helios Klinikum Erfurt, Erfurt

100029

RECRUITING

China-Japan Friendship Hospital, Beijing

100142

RECRUITING

Beijing Cancer Hospital, Beijing

101149

RECRUITING

Beijing Chest Hospital,Capital Medical University, Beijing

110042

RECRUITING

Liaoning Cancer Hospital & Institute, Shenyang

110301

RECRUITING

Taipei Medical University Hospital, Taipei

130012

RECRUITING

Jilin Province Tumor Hospital, Changchun

150081

NOT_YET_RECRUITING

Harbin Medical University Cancer Hospital, Haerbin

200032

NOT_YET_RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

200745

RECRUITING

S.C Centrul de Oncologie Sfantul Nectarie Craiova, Craiova

250117

RECRUITING

Shandong Cancer Hospital, Jinan

264099

RECRUITING

Yantai Yuhuangding Hospital, Shandong

276001

RECRUITING

Linyi Cancer Hospital, Linyi

300060

RECRUITING

Tianjin Medical University Cancer Institute & Hospital, Tianjin

310003

RECRUITING

The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou

310022

NOT_YET_RECRUITING

Zhejiang Cancer Hospital, Hangzhou

330030

RECRUITING

The Second Affiliated Hospital of Nanchang University, Jiangxi

400015

NOT_YET_RECRUITING

Institutul Oncologic 'Prof. Dr. Ion Chiricuta' Cluj Napoca, Cluj-Napoca

400030

RECRUITING

Chongqing University Cancer Hospital, Chongqing

404327

RECRUITING

China Medical University Hospital, Taichung

407280

RECRUITING

S.C Radiotherapy Center Cluj S.R.L, Bucharest

410013

RECRUITING

Hunan Cancer Hospital, Changsha

430022

RECRUITING

Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan

430030

RECRUITING

Huazhong University of Science and Technology - Tongji Medical College - Tongji Hospital Tjh, Wuhan

430079

NOT_YET_RECRUITING

Hubei Cancer Hospital, Wuhan

441021

NOT_YET_RECRUITING

Xiangyang Central Hospital, Xiangyang

450008

RECRUITING

Henan Cancer Hospital, Zhengzhou

610041

RECRUITING

Sichuan Cancer Hospital, Chengdu

RECRUITING

West China Hospital, Sichuan University, Chengdu

641000

RECRUITING

The Second Peoples Hospital of Neijiang, Neijiang

710061

RECRUITING

The First Affiliated Hospital of Xiân Jiaotong University, Xi'an

720214

NOT_YET_RECRUITING

S.C. Sigmedical Services Srl, Suceava

830000

RECRUITING

The Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi

02216

RECRUITING

Dana-Farber Cancer Institute, Boston

68198-6811

RECRUITING

University of Nebraska Medical Center, Omaha

03766

RECRUITING

Dartmouth-Hitchcock Medical Center, Lebanon

08816

RECRUITING

Astera Cancer Care, East Brunswick

07753

NOT_YET_RECRUITING

Meridian Health Systems, Neptune City

14784-400

RECRUITING

Departmento de Pesquisa Clinica- Hospital de Amor de Barretos, Barretos

88034-000

RECRUITING

Cepon - Centro de Pesquisas Oncolăgicas de Santa Catarina, Florianópolis

88301-220

RECRUITING

Clínica de Neoplasias Litoral, Itajaí

90610-000

RECRUITING

Hospital São Lucas Da Pucrs, Porto Alegre

09060-650

RECRUITING

Cepho Centro de Estudos E Pesquisas de Hematologia E Oncologia, Santo André

15090-000

RECRUITING

Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto, São José do Rio Preto

01246-000

RECRUITING

ICESP Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira, São Paulo

01308-050

NOT_YET_RECRUITING

Hospital Sirio-Libanes, São Paulo

01321-001

RECRUITING

Hospital Benefică Ncia Portuguesa de Să O Paulo, São Paulo

01327-001

RECRUITING

Hospital Alemão Oswaldo Cruz, São Paulo

01509-900

NOT_YET_RECRUITING

A. C. Camargo Cancer Center, São Paulo

L6R 3J7

RECRUITING

William Osler Health System - Brampton Civic Hospital, Brampton

T6G 1Z2

RECRUITING

Cross Cancer Institute, Edmonton

G1V 4G5

RECRUITING

Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Québec

M5G 2M9

RECRUITING

Princess Margaret Cancer Center, Toronto

R3E0V9

NOT_YET_RECRUITING

Cancercare Manitoba, Winnipeg

460 63

NOT_YET_RECRUITING

Krajska Nemocnice Liberec A.S., Liberec

140 59

NOT_YET_RECRUITING

Fakultni Thomayerova Nemocnice, Prague

124 62

NOT_YET_RECRUITING

"University General Hospital Attikon", Chaïdári

185 47

NOT_YET_RECRUITING

Metropolitan Hospital, Piraeus

06132

RECRUITING

Azienda Ospedaliera Di Perugia Ospedale S. Maria Della Misericordia, Perugia

00144

RECRUITING

Istituto Nazionale Tumori Regina Elena Irccs, Roma

104-0045

NOT_YET_RECRUITING

National Cancer Center Hospital, Chūōku

812-8582

RECRUITING

Kyushu University Hospital, Fukuoka

573-1191

RECRUITING

Kansai Medical University Hospital, Hirakata-shi

277-8577

RECRUITING

National Cancer Center Hospital East, Kashiwa

135-8550

RECRUITING

The Cancer Institute Hospital of Jfcr, Kōtoku

791-0280

RECRUITING

National Hospital Organization Shikoku Cancer Center, Matsuyama

411-8777

RECRUITING

Shizuoka Cancer Center, Nakatogari

700-8558

RECRUITING

Okayama University Hospital, Okayama

589-8511

RECRUITING

Kindai University Hospital, Ōsaka-sayama

252-0375

RECRUITING

Kitasato University Hospital, Sagamihara

003-0804

RECRUITING

National Hospital Organization Hokkaido Cancer Center, Sapporo

569-8686

RECRUITING

Osaka Medical and Pharmaceutical University Hospital, Takatsuki

641-8509

RECRUITING

Wakayama Medical University Hospital, Wakayama

5223 GZ

RECRUITING

Jeroen Bosch Ziekenhuis, 's-Hertogenbosch

1066 CX

NOT_YET_RECRUITING

Netherlands Cancer Institute, Amsterdam

6229 HX

RECRUITING

Maastricht University Medical Center, Maastricht

5022 GC

RECRUITING

Etz Elisabeth, Tilburg

85-796

RECRUITING

Centrum Onkologii Im. Prof. F. Lukaszczyka W Bydgoszczy, Bydgoszcz

93-338

NOT_YET_RECRUITING

Instytut Centrum Zdrowia Matki Polki, Lodz

05-400

NOT_YET_RECRUITING

Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy, Otwock

82-550

NOT_YET_RECRUITING

Szpital Specjalistyczny W Prabutach, Prabuty

97-200

RECRUITING

Provita Prolife, Tomaszów Mazowiecki

4835-044

NOT_YET_RECRUITING

Hospital Da Senhora Da Oliveira Guimară Es, Guimarães

1500-650

NOT_YET_RECRUITING

Hospital Da Luz, Lisbon

1769-001

NOT_YET_RECRUITING

Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital Pulido Valente, Lisbon

4099-001

NOT_YET_RECRUITING

Centro Hospitalar Do Porto, E.P.E. - Hospital de Santo António, Porto

03722

RECRUITING

Severance Hospital, Yonsei University Health System, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

08036

RECRUITING

Hospital Clinic de Barcelona, Barcelona

08908

RECRUITING

Ico L'Hospitalet - Hospital Duran I Reynals, L'Hospitalet de Llobregat

06105

RECRUITING

Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara

B9 5SS

RECRUITING

Birmingham Heartlands Hospital, Birmingham

LS9 7TF

RECRUITING

St James'S University Hospital, Leeds

OX3 7LJ

RECRUITING

Churchill Hospital, Oxford

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Daiichi Sankyo

INDUSTRY