A Randomized Controlled Trial for Surgical Treatment of Recurrent Adult Tethered Cord Syndrome

NANot yet recruitingINTERVENTIONAL
Enrollment

222

Participants

Timeline

Start Date

February 1, 2024

Primary Completion Date

December 31, 2026

Study Completion Date

May 31, 2027

Conditions
Recurrent Adult Tethered Cord Syndrome
Interventions
PROCEDURE

Detethering Surgery

Detethering surgery, or cord untethering, is a conventional surgical approach for treating tethered cord syndrome (TCS). It involves releasing the spinal cord from its abnormal attachment. During the surgical procedure, once the tethered area is identified, careful microsurgical techniques are used to separate the spinal cord from the surrounding abnormal tissue. This operation aims to alleviate the symptoms of TCS by removing the cause of tension on the spinal cord.

PROCEDURE

Spinal Column Shortening Surgery

"Spinal column shortening surgery is an innovative surgical approach that involves reducing the tension on the spinal cord by shortening the spinal column, effectively untethering the spinal cord indirectly. The procedure primarily involves the thoracolumbar region.The choice of this region for intervention offers several advantages: it is a safe distance from the previous detethering surgery area; it is closer to the conus medullaris of the spinal cord, ensuring better treatment effectiveness; and the impact on spinal mobility is minimal after internal fixation at this region. This technique is designed to alleviate TCS symptoms while minimizing the risk of postoperative cerebrospinal fluid (CSF) leakage, which is a common complication in direct untethering procedures for recurrent cases. All procedures will be conducted by trained and experienced neurosurgeons following standardized protocols."

Trial Locations (1)

100000

Xuanwu Hospital, Capital Medical University, Beijing

All Listed Sponsors
collaborator

Chinese PLA General Hospital

OTHER

collaborator

Seventh Medical Center of PLA Army General Hospital

OTHER

collaborator

Chifeng Municipal Hospital

OTHER

collaborator

The First Hospital of Hebei Medical University

OTHER

lead

Xuanwu Hospital, Beijing

OTHER

NCT06197399 - A Randomized Controlled Trial for Surgical Treatment of Recurrent Adult Tethered Cord Syndrome | Biotech Hunter | Biotech Hunter