A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

479

Participants

Timeline

Start Date

February 27, 2024

Primary Completion Date

February 19, 2026

Study Completion Date

June 11, 2026

Conditions
Severe Asthma
Interventions
DRUG

Verekitug (UPB-101)

Verekitug (UPB-101) formulated solution

DRUG

Placebo

Verekitug (UPB-101) matching placebo

Trial Locations (155)

1407

Medical Center Excelsior, Sofia

1510

Medical Center HERA EOOD, Sofia

1680

DCC Convex, Sofia

1756

Medconsult Pleven, Sofia

Medical center Pulmovizhyn, Sofia

1888

IERIM Instituto de Enfermedades Respiratorias e Investigacion Medica, San Juan Bautista

1935

FCRN Clinical Trial Centre, Vereeniging

2000

Fundacion Estudios Clinicos (FECLIN), Rosario

Instituto Especialidades de la Salud Rosario, Rosario

2001

Newtown Clinical Research Centre, Johannesburg

2300

"MHAT Rahila Angelova Pernik", Pernik

2447

Kyung Hee University Hospital, Seoul

3080

Seoul National University Hospital, Seoul

3320

MC Zdrave 1, Vratsa

3722

Yonsei University Health System - Severance Hospital, Seoul

4000

Office of Hector H. Altieri MD, San Miguel de Tucumán

4001

UMHAT Sveti Georgi, Plovdiv

Synapta Clinical Research Centre, Durban

St Augustine's Hospital/Dr. IA Abdullah, Durban

5500

Fundacion Scherbovsky, Mendoza

INSARES, Mendoza

6001

Medical Center New Rehabilitation Center EOOD, Stara Zagora

6351

Samsung Medical Center, Seoul

7000

Ambulatory For Specialized Outpatient Medical Care - Individual Practice - Dr. Nikolay Evgeniev Ruse Ltd, Rousse

7700

University of Cape Town Lung Institute, Cape Town

10043

SSD Asma Grave e Malattie Rare del Polmone, AOU San Luigi Gonzaga, Orbassano

10459

Urban Health Plan INC, The Bronx

10717

RCMS/Lungenpraxis Hohenzollerndamm, Berlin

10787

Velocity Clinical Research Germany , Berlin, Berlin

10961

Pneumologisches Studienzentrum, Berlin

14584

Soonchunhyang University Bucheon Hospital, Bucheon-si

16132

Ospedale San Martino, Genova

21044

Howard County Center for Lung and Sleep Medicine LLC, Columbia

21050

"Medical Centre Neuromed of Limited Liability Company Scan Light", Vinnytsia

21162

Chesapeake Clinical Research Inc, White Marsh

22299

ME Clinical Respiratory Research Hamburg GmbH, Hamburg

27100

"Fondazione IRCCS Policlinico San Matteo - SC Pneumologia'", Pavia

28007

Hospital Gregorio Marañon, Madrid

28078

Advanced Respiratory and Sleep Medicine LLC, Huntersville

28644

Chungbuk National University Hospital, Cheongju-si

29303

Velocity Clinical Research - Spartanburg, Spartanburg

29414

WR-Notus Clinical Research, LLC, Charleston

29621

Velocity Clinical Research - Anderson, Anderson

30038

Pivotal Research Solutions, Stonecrest

30518

RNA America Health Sciences, Sugar Hill

32789

Clinical Site Partners dba Flourish research, Winter Park

Clinical Site Partners, LLC dba Flourish Research, Winter Park

32806

Anderson Allergy And Asthma, PA, Orlando

33155

Health and Life Research Institute, LLC, Miami

33165

Phoenix Medical Research, Miami

33172

Unique Clinical Trials, Doral

33173

Research Institute of South Florida, Miami

33189

Advance Pharma Research, Cutler Bay

Nouvelle Clinical Research, Miami

33317

Edward Jenner Research Group, LLC, Plantation

33614

R&B Medical Center, Tampa

35209

AllerVie Clinical Research, Birmingham

37421

WR-ClinSearch, LLC, Chattanooga

42415

Yeungnam University Hospital, Daegu

43617

Toledo Institute of Clinical Research Inc, Toledo

44262

Summit Research Group LLC, Munroe Falls

48336

Pulmonary Research Institute of Southeast Michigan, Farmington Hills

48504

AA Medical Research Center, Flint

53792

University of Wisconsin--Madison, Madison

55128

IKF Pneumologie GmbH & Co. KG, Mainz

55905

Mayo Clinic, Rochester

56068

KPPK Studienzentrum, Koblenz

58001

Chernivtsi Regional Clinical Hospital, Chernivtsi

60596

IKF Pneumologie Frankfurt, Clinical Research Center Respiratory Diseases, Hessen

70508

Velocity Clinical Research - Lafayette LA, Los Angeles

73034

OK Clinical Research, LLC, Edmond

75069

Metroplex Pulmonary and Sleep Center Drive, McKinney

75225

Alina Clinical Trials, LLC, Dallas

75231

AARA Research Center, Dallas

76018

"Municipal non-Profit Enterprise lvano-Frankivsk Regional Phthisiology-Pulmonology Center of lvano-Frankivsk regional council", Ivano-Frankivsk

77008

Greater Houston Memorial Pulmonary and Sleep, Houston

77375

DM Clinical Tomball, Tomball

77429

Horizon Clinical Research, Cypress

78028

Sante Clinical Research, Kerrville

78258

Element Research Group, San Antonio

79902

El Paso Pulmonary Association, El Paso

80131

UOSD Allergologia e Immunodeficienze dell'A.O.U. Federico II, Napoli

80206

National Jewish Health, Denver

83642

Velocity Clinical Research - Meridian, Meridian

83706

Treasure Valley Medical Research, Boise

84088

Velocity Clinical Research, West Jordan

89106

M3 Wake Research, Las Vegas

91324

California Medical Research Associates Inc., Northridge

91786

Integrated Research of Inland Inc, Upland

92663

Newport Native MD Inc, Newport Beach

92683

Allianz Research Institute, Westminster

93301

Kern Research, Inc., Bakersfield

94598

Allergy & Asthma Clinical Research, Walnut Creek

95695

Woodland Clinic Medical Group, Woodland

97015

Portland Clinical Research, Clackamas

97504

Velocity Clinical Research - Medford, Medford

4070280

Centro Médico BIOREUMA, Concepción

7500657

CIMER, Providencia

7501126

Sociedad medica Sy G Limitada, Santiago

7630226

Fundacion Medica San Cristobal, Santiago

8241479

Icegclinic, Santiago

02723

Exordia Medical Research Inc, Fall River

02747

Mayflower Clinical, Marble Falls

C1414AIF

CARE: Centro de Alergia y Enfermedades Respiratorias, Buenos Aires

C1426ABP

Fundacion Respirar - Centro Medico Dra. De Salvo, Buenos Aires

C1121ABE

Fundacion Cidea, Caba

C1425BEN

InAER, CABA

M5500

Centro Medico Dharma, Mendoza

X5003DCE

Centro Dr. Lazaro Langer Privado Medicina del Aparato Respiratorio, Córdoba

E3260

Centro de Medicina Respiratoria, Concepción del Uruguay

CP T4000IAP

Investigaciones En Patologias Respiratorias, San Miguel de Tucumán

L1S 2J5

Dynamic Drug Advancement, Ajax

K1H 1E4

Ottawa Allergy Research Corp, Ottawa

M5G1E2

Toronto Allergists, Toronto

K0C 2K0

Winchester Hospital, Winchester

602 00

Fakultni Nemocnice u Sv. Anny v Brne, Brno

586 01

Alergologie a imunologie Hofstetr Alois MUDr. s.r.o., Jihlava

415 01

Plicni Stredisko Teplice S.R.O, Teplice

407 47

PNEUMOLOGIE VARNSDORF s.r.o., Varnsdorf

04347

POIS Sachsen GmbH, Leipzig

062-0931

KKR Sapporo Medical Center, Sapporo

053-8506

Oji General Hospital, Tomakomai

319-1113

National Hospital Organization Ibarakihigashi National Hospital, Ibaraki

545-0051

Osaka Metropolitan University Hospital, Osaka

232-0024

Yokohama City University Medical Center, Yokohama

583-8588

Osaka Habikino Medical Center, Habikino

596-8501

Kishiwada City Hospital, Kishiwada

103-0027

Tokyo-Eki Center-building Clinic, Chuo-ku

104-0031

Fukuwa Clinics, Chuo-ku

51-162

Centrum Badan Klinicznych, Wroclaw

53-201

"ALL-MED Specjalistyczna Opieka Medyczna. Medyczny Instytut Badawczy", Wroclaw

54-239

Lekarze Specjalisci - J. Malolepszy I Partnerzy, Wroclaw

30-033

Centrum Medyczne All-Med Spolka Komandytowa, Krakow

31-159

Nzoz Atopia, Krakow

31-624

Malopolskie Centrum Alergologii, Krakow

33-100

Alergo-Med Specjalistyczna Przychodnia Lekarska Sp Z O.O., Tarnów

35-051

Prywatny Gabinet Lekarski Malgorzata Pawlukiewicz, Rzeszów

35-205

EMED Centrum Uslug Medycznych, Rzeszów

15-044

Centrum Medycyny Oddechowej, Mroz Spolka Jawna, Bialystok

80-214

Uniwersyteckie Centrum Kliniczne, Klinika Alergologii i Pneumonologii, Gdansk

27-400

Ostrowieckie Centrum Medyczne spolka cywilna Anna Olech-Cudzik, Krzysztof Cudzik, Ostrowiec Świętokrzyski

0002

Emmed Research, Pretoria

03312

Eunpyeong St. Marys Hospital, Seoul

06591

The Catholic University of Korea, Seoul St. Marys Hospital, Seoul

05505

Asan Medical Center, Seoul

08017

Giromed Institute, Girona

HU16 5JQ

Hull University Teaching Hospitals NHS Trust, Cottingham

L7 8XP

Royal Liverpool University Hospital, Liverpool

BT7 2EB

Ormeau Clinical Trials Ltd, Belfast

OX3 7LE

Churchill Hospital, Oxford

G12 0YN

Asthma/COPD Clinical Research Centre, Glasgow

KT16 0PZ

St Peter's Hospital, Chertsey

B9 5SS

Heartlands Hospital, University Hospitals Birmingham NHS Trust, Birmingham

BD9 6RJ

Bradford Royal Infirmary, Bradford

Duckworth Lane Clinical Research Facility, Bradford

All Listed Sponsors
lead

Upstream Bio Inc.

INDUSTRY

NCT06196879 - A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT) | Biotech Hunter | Biotech Hunter