Stereotactic Body Radiotherapy Combined With PD-1 Blockers for Locally Advanced or Locally Recurrent Pancreatic Cancer

CompletedOBSERVATIONAL
Enrollment

19

Participants

Timeline

Start Date

December 1, 2020

Primary Completion Date

May 21, 2023

Study Completion Date

December 15, 2023

Conditions
Stereotactic Body RadiotherapyPD-1 InhibitorsPancreatic Cancer
Interventions
RADIATION

Stereotactic body radiotherapy (SBRT)

All the patients first received SBRT with the dose of 25Gy up to 50Gy in five fractions.

DRUG

PD-1 blocking antibody

All the patients first received SBRT with the dose of 25Gy up to 50Gy in five fractions and then received the treatment of PD-1 blockers including pembrolizumab (200 mg every 3 weeks), carelizumab (200 mg every 3 weeks), tislelizumab (200 mg every 3 weeks), sintilimab (200 mg every 3 weeks), zimberelimab (240 mg every 3 weeks) until the tumor progressed or the side effects became intolerable.

Trial Locations (1)

100191

Junjie Wang, Beijing

All Listed Sponsors
lead

Peking University Third Hospital

OTHER

NCT06195254 - Stereotactic Body Radiotherapy Combined With PD-1 Blockers for Locally Advanced or Locally Recurrent Pancreatic Cancer | Biotech Hunter | Biotech Hunter