Evaluation of Treatment by Glofitamab in Combination With Rituximab or Obinutuzumab Plus CHOP in Patients With RIchter Syndrome

PHASE2RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

March 21, 2024

Primary Completion Date

March 1, 2026

Study Completion Date

March 1, 2027

Conditions
Richter Syndrome
Interventions
DRUG

Glofitamab + Obinutuzumab

Duration of each cycle is 21 days. Cycle 1: R-CHOP Cycle 2: G-CHOP + glofitamab (at this cycle onnly, Obinutuzumab will be injected instead of Rituximab in order to decreased the risk of cytokine released syndrome) Cycle 3-6: R-CHOP + glofitamab Cycle 7-8: glofitamab alone

Trial Locations (22)

31059

RECRUITING

Toulouse - IUCT Oncopole - Service d'Hématologie, Toulouse

33604

NOT_YET_RECRUITING

Bordeaux Pessac, Pessac

34295

NOT_YET_RECRUITING

MONTPELLIER - Hôpital Saint-Eloi - Hématologie Clinique, Montpellier

35033

NOT_YET_RECRUITING

RENNES - CHU Pontchaillou - Hématologie Clinique, Rennes

37000

NOT_YET_RECRUITING

TOURS - Hôpital Bretonneau, Tours

38043

NOT_YET_RECRUITING

Grenoble - CHUGA - Hématologie Clinique, Grenoble

49933

NOT_YET_RECRUITING

Angers Chu, Angers

51092

NOT_YET_RECRUITING

Reims Chu, Reims

54500

NOT_YET_RECRUITING

NANCY - CHU Brabois, Vandœuvre-lès-Nancy

59000

NOT_YET_RECRUITING

LILLE GHICL - Hôpital Saint Vincent de Paul, Lille

59037

NOT_YET_RECRUITING

LILLE CHU - Hôpital Claude Huriez, Lille

63000

NOT_YET_RECRUITING

Clermont-Ferrand - Chu Estaing, Clermont-Ferrand

64109

NOT_YET_RECRUITING

BAYONNE - CH de la Côte Basque - Hématologie, Bayonne

67033

NOT_YET_RECRUITING

Strasbourg - Icans, Strasbourg

69008

NOT_YET_RECRUITING

LYON-Centre Léon Bérard, Lyon

69036

RECRUITING

LYON HCL - CH Lyon Sud, Pierre-Bénite

75010

NOT_YET_RECRUITING

APHP - Hôpital Saint-Louis - Hématologie adultes, Paris

75012

NOT_YET_RECRUITING

APHP - Hôpital Saint-Antoine - Hématologie et thérapie cellulaire, Paris

75651

NOT_YET_RECRUITING

APHP - Hôpital Pitié Salpêtrière - Hématologie, Paris

76038

NOT_YET_RECRUITING

ROUEN - Centre Henri Becquerel - Service Hématologie Clinique, Rouen

80054

NOT_YET_RECRUITING

Amiens-Picardie Chu, Amiens

87042

NOT_YET_RECRUITING

LIMOGES - CHU Dupuytren 1, Limoges

All Listed Sponsors
collaborator

Hoffmann-La Roche

INDUSTRY

lead

French Innovative Leukemia Organisation

OTHER