Sirolimus Coated BALloon Versus Standard Balloon Angioplasty in The Treatment of Below The Knee Arterial Disease

NARecruitingINTERVENTIONAL
Enrollment

368

Participants

Timeline

Start Date

January 16, 2025

Primary Completion Date

December 1, 2026

Study Completion Date

February 1, 2031

Conditions
Arterial Disease of LegsBelow-the-knee ObstructionPAD - Peripheral Arterial Disease
Interventions
DEVICE

MagicTouch PTA Sirolimus drug coated balloon

All patients must first be treated with pre dilatation with a standard balloon angioplasty using any standard balloon catheters at the discretion of the operator. Magic Touch PTA Sirolimus coated balloon catheter is an adjunct treatment that should be used in combination with standard balloon angioplasty. Following successful crossing of wire across the lesion and plain balloon angioplasty of arterial lesion with successful lesion preparation with residual lesion \<30%, subjects will be randomized to receive study device balloon. If patients are assigned to MagicTouch PTA Sirolimus DCB, the Angioplasty of lower limb will be performed with this device in addition to standard balloon angioplasty.

DEVICE

Placebo balloon angioplasty

For participants randomized to a Placebo balloon angioplasty group, a Placebo balloon angioplasty in addition to standard balloon angioplasty will be performed.

Trial Locations (23)

10029

RECRUITING

The Mount Sinai Hospital, New York

10032

RECRUITING

Columbia University Irving Medical center/NYPH, New York

10065

RECRUITING

New York Presbyterian - Weill Cornell Medical Center Vascular & Endovascular Surgery, New York

10595

RECRUITING

Westchester Medical Center, Valhalla

11042

RECRUITING

Northwell Health Long Island Jewish Medical Center, Lake Success

19010

RECRUITING

Lankenau Institute for Medical Research Bryn Mawr Hospital, Bryn Mawr

19104

RECRUITING

University of Pennsylvania - Penn Heart and Vascular Center, Philadelphia

29425

RECRUITING

Medical University of South Carolina(MUSC) Health Ashley River Tower, Charleston

33176

RECRUITING

Baptist Hospital of Miami, Miami

33606

RECRUITING

University of South Florida, Tampa

33756

RECRUITING

Clearwater Cardiovascular Consultants, Clearwater

44106

RECRUITING

University Hospitals Cleveland Medical Center, Cleveland

45219

RECRUITING

The Christ Hospital Network Outpatient Center, Cincinnati

50309

RECRUITING

Unity Point Health Des Moines, Des Moines

52807

RECRUITING

Vascular Institute of the Midwest, Davenport

75093

RECRUITING

The Heart Hospital Baylor Plano, Plano

75226

RECRUITING

Baylor Research Institute, Dallas

78705

RECRUITING

Ascension Seton Medical Center Austin, Austin

85258

RECRUITING

Honor Health Research & Innovation Institute, Scottsdale

90095

NOT_YET_RECRUITING

University of California Los Angeles, Los Angeles

98104

RECRUITING

University of Washington Seattle, Seattle

08015

RECRUITING

Deborah Heart and Lung Center, Browns Mills

08053

RECRUITING

Virtua Healthcare - Virtua Our Lady of Lourdes, Marlton

Sponsors
All Listed Sponsors
lead

Concept Medical Inc.

INDUSTRY