72
Participants
Start Date
January 31, 2012
Primary Completion Date
July 1, 2012
Study Completion Date
December 31, 2024
Scaling and root planing
SRP will be performed in four to six appointments lasting approximately 1 h each, using manual curettes (Hu-Friedy, Chicago, IL, USA) and ultrasonic device (Cavitron Select SPC, Dentsply professional, York, PA, USA) under local anesthesia. The deep sites will be scaled throughout the first week and treatment of the entire oral cavity will be completed in 14 days.
Placebos during SRP
Amoxicillin and metronidazole placebos thrice a day for 14 days, beginning with the first SRP session.
Placebos after SRP
Amoxicillin and metronidazole placebos thrice a day for 14 days, beginning after the last SRP session.
Metronidazole during SRP
Metronidazole 400 mg, thrice a day for 14 days, beginning with the first SRP session.
Amoxicillin during SRP
Amoxicillin 500 mg, thrice a day for 14 days, beginning with the first SRP session.
Metronidazole after SRP
Metronidazole 400 mg, thrice a day for 14 days, beginning after the last SRP session.
Amoxicillin after SRP
Amoxicillin 500 mg, thrice a day for 14 days, beginning after the last SRP session.
University of Guarulhos, Guarulhos
Belén Retamal-Valdes
OTHER