Prognostic Value of Exhaled Isoprene Levels for Morbidity and Functional Outcome in Cardiosurgical Patients

RecruitingOBSERVATIONAL
Enrollment

66

Participants

Timeline

Start Date

November 27, 2023

Primary Completion Date

October 1, 2025

Study Completion Date

December 31, 2025

Conditions
FrailtyMuscle WeaknessVolatile Organic CompoundsIsoprene
Interventions
DIAGNOSTIC_TEST

Physical performance testing

Assessment of physical performance using established clinical tests and scoring systems

DIAGNOSTIC_TEST

Breath sampling and VOC analysis

Sampling of exhaled breath and using Proton-transfer-reaction time-of-flight mass spectrometry (PTR-TOF) for VOC quantification.

DIAGNOSTIC_TEST

Muscle ultrasound

Quantitative and qualitative assessment of different limb skeletal muscles using non-invasive ultrasound.

DIAGNOSTIC_TEST

Blood-based biomarker analysis

Blood sampling and assessment of different blood-based biomarkers of muscle integrity using Enzyme-linked Immunosorbent Assay (ELISA) and Electrochemiluminescence Immunoassay (ECLIA)

Trial Locations (1)

18057

RECRUITING

Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Rostock University Medical Center, Rostock

All Listed Sponsors
collaborator

Prof. Dr. Daniel A. Reuter, Head of Department, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Rostock University Medical Center

UNKNOWN

collaborator

Prof. Dr. Christian D. Etz, Head of Department, Department of Cardiac Surgery, Rostock University Medical Center

UNKNOWN

collaborator

PD Dr. Johannes Ehler, Consultant, Department of Anesthesiology and Intensive Care Medicine, University Hospital Jena

UNKNOWN

lead

University of Rostock

OTHER