The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin

PHASE4CompletedINTERVENTIONAL
Enrollment

23

Participants

Timeline

Start Date

September 22, 2023

Primary Completion Date

February 13, 2024

Study Completion Date

May 1, 2024

Conditions
Blood Coagulation Disorder
Interventions
DRUG

Unfractionated heparin

15,000 units of unfractionated heparin administered in the thigh

BEHAVIORAL

Double-legged cycle ergometer exercise

One hour of double-leg cycle ergometer exercise

BEHAVIORAL

Single-legged cycle ergometer exercise, with unfractionated heparin injection in the exercising leg

One hour of single-leg cycle ergometer exercise, after unfractionated heparin injection in the ipsilateral leg

BEHAVIORAL

Single-legged cycle ergometer exercise, with unfractionated heparin injection in the non-exercising leg

One hour of single-leg cycle ergometer exercise, after unfractionated heparin injection in the ipsilateral leg

BEHAVIORAL

No exercise

No exercise

Trial Locations (1)

2400

Bispebjerg-Frederiksberg Hospital, Department of Clinical Pharmacology, Copenhagen

All Listed Sponsors
lead

Kristian Karstoft

OTHER

NCT06174961 - The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin | Biotech Hunter | Biotech Hunter