A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome

PHASE4RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

December 12, 2023

Primary Completion Date

October 31, 2025

Study Completion Date

December 31, 2025

Conditions
Dental CariesWhite Spot LesionInitial CariesIncipient Enamel Caries
Interventions
DIETARY_SUPPLEMENT

Vitamin D supplements along with behavioral modification

"Vitamin D soft gel capsules of 50,000 IU/week for two months followed by a maintenance dosage of 5000 IU/day for one month.~Behavior modification for dental caries with standard instructions of brushing teeth twice daily with regular fluoridated toothpaste and diet counseling."

COMBINATION_PRODUCT

Topical fluoride application and Vitamin D supplements along with behavioral modification

"Professional topical 5% sodium fluoride gel application for 5 minutes on the teeth having ICL.~Behavior modification for dental caries with standard instructions of brushing teeth twice daily with regular fluoridated toothpaste and diet counseling.~Vitamin D soft gel capsules of 50,000 IU/week for two months followed by a maintenance dosage of 5000 IU/day for one month.~Behavior modification for dental caries with standard instructions of brushing teeth twice daily with regular fluoridated toothpaste and diet counseling."

PROCEDURE

Topical fluoride application along with behavioral modification

"Professional topical 5% sodium fluoride gel application for 5 minutes on the teeth having ICL.~Behavior modification for dental caries with standard instructions of brushing teeth twice daily with regular fluoridated toothpaste and diet counseling.~Behavior modification for dental caries with standard instructions of brushing teeth twice daily with regular fluoridated toothpaste and diet counseling."

Trial Locations (1)

75330

RECRUITING

Dr Saba Arshad, Karachi

All Listed Sponsors
collaborator

University of Karachi

OTHER

lead

Dow University of Health Sciences

OTHER