NCT06171438View on ClinicalTrials.gov

Molecular Markers of Acute Kidney Injury in Elderly Deceased Donors

CompletedOBSERVATIONAL
Enrollment

200

Participants

Timeline

Start Date

June 11, 2021

Primary Completion Date

December 1, 2022

Study Completion Date

October 31, 2023

Conditions
Kidney TransplantationAcute Kidney Injury
Interventions
DIAGNOSTIC_TEST

Urine Biomarkers

Biomarkers of kidney damage in donors, such as neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-D-glucosaminidase (NAG), beta2-microglobulin, alpha1-microglobulin, alpha2-macroglobulin and transferrin will be measured by ELISA.

DIAGNOSTIC_TEST

Gene expression profiling of donor kidneys by microarray

Gene expression profiling of donor kidney biopsies using Affymetrix microarray platform (PrimeView Human Gene Expression Array).

DIAGNOSTIC_TEST

Gene expression profiling of recipient kidneys by microarray

Gene expression profiling of donor kidney biopsies using Affymetrix microarray platform (PrimeView Human Gene Expression Array).

Trial Locations (1)

140 21

Institute for Clinical and Experimental Medicine, Prague

All Listed Sponsors
lead

Institute for Clinical and Experimental Medicine

OTHER_GOV