Comparing the Combination of Selinexor-Daratumumab-Velcade-Dexamethasone (Dara-SVD) With the Usual Treatment (Dara-RVD) for High-Risk Newly Diagnosed Multiple Myeloma

PHASE2RecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

July 23, 2024

Primary Completion Date

September 30, 2026

Study Completion Date

September 30, 2026

Conditions
Multiple Myeloma
Interventions
PROCEDURE

Biospecimen Collection

Undergo collection of blood and urine samples

PROCEDURE

Bone Marrow Aspiration

Undergo bone marrow aspiration

PROCEDURE

Bone Marrow Biopsy

Undergo bone marrow biopsy

DRUG

Bortezomib

Given SC

PROCEDURE

Computed Tomography

Undergo CT

DRUG

Daratumumab and Recombinant Human Hyaluronidase

Given SC

DRUG

Dexamethasone

Given PO

DRUG

Lenalidomide

Given PO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo PET

DRUG

Selinexor

Given PO

Trial Locations (27)

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10065

RECRUITING

NYP/Weill Cornell Medical Center, New York

11220

RECRUITING

NYU Langone Hospital - Brooklyn, Brooklyn

11501

RECRUITING

NYU Langone Hospital - Long Island, Mineola

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92653

RECRUITING

UCI Health Laguna Hills, Laguna Hills

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

95817

RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

06418

RECRUITING

Smilow Cancer Hospital-Derby Care Center, Derby

06824

RECRUITING

Smilow Cancer Hospital Care Center-Fairfield, Fairfield

06033

RECRUITING

Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury

06830

RECRUITING

Smilow Cancer Hospital Care Center at Greenwich, Greenwich

06437

RECRUITING

Smilow Cancer Hospital Care Center - Guilford, Guilford

06105

RECRUITING

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06510

RECRUITING

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

RECRUITING

Yale University, New Haven

06473

RECRUITING

Yale-New Haven Hospital North Haven Medical Center, North Haven

06902

RECRUITING

Smilow Cancer Hospital Care Center at Long Ridge, Stamford

06790

RECRUITING

Smilow Cancer Hospital-Torrington Care Center, Torrington

06611

RECRUITING

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06708

RECRUITING

Smilow Cancer Hospital-Waterbury Care Center, Waterbury

06385

RECRUITING

Smilow Cancer Hospital Care Center - Waterford, Waterford

02891

RECRUITING

Smilow Cancer Hospital Care Center - Westerly, Westerly

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH