Volatile Organic Compounds as Breath Biomarkers in Squamous Oesophageal Neoplasms

RecruitingOBSERVATIONAL
Enrollment

518

Participants

Timeline

Start Date

December 1, 2023

Primary Completion Date

November 30, 2026

Study Completion Date

December 31, 2026

Conditions
Oesophageal Squamous Cell CarcinomaOesophageal Cancer
Interventions
OTHER

Exhaled breath sampling

Participants will maintain a clear fluid diet for a minimum of 6 hours prior to breath collection. Participants will be asked to provide a breath sample by exhaling into single-use breath collection bags. Using a custom designed gas sampling pump, the breath VOCs will be transferred onto TD tubes at a controlled flow rate. This breath sampling procedure will be repeated once. When the participants' breath sampling is complete, room air (Blank) samples must be taken onto additional TD tubes using the same procedure. The TD tubes will be sealed with long-term storage caps using the CapLok Tool.

Trial Locations (13)

W12 0NN

RECRUITING

Imperial College Healthcare NHS Trust, London

Unknown

RECRUITING

Hull University Teaching Hospitals NHS Trust, Cottingham

NOT_YET_RECRUITING

Cardiff and Vale University Health Board, Cardiff

NOT_YET_RECRUITING

Velindre NHS Trust, Cardiff

RECRUITING

University Hospitals Coventry and Warwickshire NHS Trust, Coventry

RECRUITING

University Hospitals of Leicester NHS Foundation Trust, Leicester

NOT_YET_RECRUITING

Liverpool University Hospitals NHS Foundation Trust, Liverpool

RECRUITING

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

NOT_YET_RECRUITING

Bedfordshire Hospitals NHS Foundation Trust, Luton

RECRUITING

Newcastle Upon Tyne Hospitals NHS Trust, Newcastle

RECRUITING

Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich

RECRUITING

Oxford University Hospitals NHS Trust, Oxford

NOT_YET_RECRUITING

Portsmouth Hospitals University NHS Trust, Portsmouth

All Listed Sponsors
collaborator

Imperial College Healthcare NHS Trust

OTHER

collaborator

Hull University Teaching Hospitals NHS Trust

OTHER_GOV

collaborator

Norfolk and Norwich University Hospitals NHS Foundation Trust

OTHER

collaborator

University Hospitals Coventry and Warwickshire NHS Trust

OTHER

collaborator

Oxford University Hospitals NHS Trust

OTHER

collaborator

Velindre NHS Trust

OTHER_GOV

collaborator

Cardiff and Vale University Health Board

OTHER_GOV

collaborator

Newcastle-upon-Tyne Hospitals NHS Trust

OTHER

collaborator

Liverpool University Hospitals NHS Foundation Trust

OTHER_GOV

collaborator

Bedfordshire Hospitals NHS Foundation Trust

OTHER

collaborator

University Hospitals, Leicester

OTHER

collaborator

The Clatterbridge Cancer Centre NHS Foundation Trust

OTHER

collaborator

Portsmouth Hospitals NHS Trust

OTHER_GOV

collaborator

University Hospital Plymouth NHS Trust

OTHER

collaborator

NHS Tayside

OTHER_GOV

collaborator

NHS Highlands

OTHER

collaborator

The Christie NHS Foundation Trust

OTHER

collaborator

North Cumbria University Hospitals NHS Trust

OTHER

collaborator

Maidstone & Tunbridge Wells NHS Trust

OTHER

collaborator

University Hospitals of Derby and Burton NHS Foundation Trust

OTHER

collaborator

Bradford Teaching Hospitals NHS Foundation Trust

OTHER_GOV

collaborator

East and North Hertfordshire NHS Trust

OTHER_GOV

lead

Imperial College London

OTHER