NCT06168214View on ClinicalTrials.gov

Standard or Short-course Vonoprazan Non-bismuth Triple Therapy or High-dose Dual Therapy Versus Rabeprazole-bismuth Quadruple Therapy for Primary Helicobacter Pylori Eradication

PHASE4RecruitingINTERVENTIONAL
Enrollment

1,404

Participants

Timeline

Start Date

September 4, 2023

Primary Completion Date

November 25, 2024

Study Completion Date

December 25, 2024

Conditions
the Eradication Rates of Helicobacter Pylori
Interventions
DRUG

Rabeprazloe+bismuth+amoxicillin+clarithromycin

PBAC: 14D: PPI: Rabeprazole 10mg bid; B: bismuth potassium citrate240mg bid/ colloidal bismuth pectin 300mg bid/ colloidal bismuth tartrate 220mg bid; A:amoxicillin1000mg bid; C: clarithromycin 500mg bid.

DRUG

Vonoprazan+amoxicillin+clarithromycin 14 days

VAC14: 14D: V: vonoprazan 20mg bid; A: amoxicillin1000mg bid; C: clarithromycin 500mg bid.

DRUG

Vonoprazan+amoxicillin+clarithromycin 7 days

VAC7: 7D: V: vonoprazan 20mg bid; A: amoxicillin1000mg bid; C: clarithromycin 500mg bid.

DRUG

Vonoprazan+tetracycline+furazolidone 14 days

VTF14: 14D: V: vonoprazan 20mg bid; T: tetracycline 500mg tid; F: furazolidone 100mg bid.

DRUG

Vonoprazan+tetracycline+furazolidone 7 days

VTF7: 7D: V: vonoprazan 20mg bid; T: tetracycline 500mg tid; F: furazolidone 100mg bid.

DRUG

Vonoprazan+amoxicillin+furazolidone 7 days

hVAF: 7D: V: vonoprazan 20mg bid; A: amoxicillin1000mg tid; F: furazolidone 100mg bid.

DRUG

Vonoprazan+amoxicillin+tetracycline 14 days

hVAT: 14D: V: vonoprazan 20mg bid; A: amoxicillin1000mg tid; T: tetracycline 500mg tid.

DRUG

Vonoprazan+amoxicillin 7 days

hVA7: 7D: V: vonoprazan 20mg bid; A: amoxicillin1000mg tid.

DRUG

Vonoprazan+amoxicillin 14 days

hVA14: 14D: V: vonoprazan 20mg bid; A: amoxicillin1000mg tid.

Trial Locations (1)

710032

RECRUITING

Ying han, Xi'an

All Listed Sponsors
lead

Xijing Hospital of Digestive Diseases

OTHER