Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

616

Participants

Timeline

Start Date

January 18, 2024

Primary Completion Date

June 30, 2027

Study Completion Date

December 31, 2028

Conditions
Non-Small Cell Lung Cancer, NSCLCKRAS, NRAS, HRAS-mutated NSCLCKRAS G12C-mutated Solid Tumors, Lung CancerLung Cancer Stage IV, Advanced Solid Tumor, CancerRAS G12D-mutated NSCLC
Interventions
DRUG

RMC-6291

Oral tablet

DRUG

RMC-6236

Oral tablet

DRUG

Pembrolizumab

IV Infusion

DRUG

Cisplatin

IV Infusion

DRUG

Carboplatin

IV Infusion

DRUG

Pemetrexed

IV infusion

DRUG

RMC-9805

Oral Tablet

Trial Locations (65)

116

RECRUITING

Taipei Municipal Wanfang Hospital, Taipei

1066

RECRUITING

The Netherlands Cancer Institute (NKI), Amsterdam

3584

RECRUITING

University Medical Center Utrecht, Utrecht

9713

RECRUITING

University Medical Centre Groningen, Groningen

10016

RECRUITING

New York University Langone Health, New York

10029

RECRUITING

Icahn School of Medicine at Mount Sinai, New York

10032

RECRUITING

Columbia University Medical Center, New York

10043

RECRUITING

A.O.U. San Luigi Gonzaga-Orbassano - SCDU Oncologia Medica, Orbassano

11590

RECRUITING

Clinical Research Alliance, Westbury

12203

RECRUITING

Charite-Universitaetsmedizin Berlin - Campus Charite Mitte, Berlin

14076

RECRUITING

Centre François Baclesse, Caen

15006

RECRUITING

Complejo Hospitalario Universitario A Coruña, A Coruña

15232

RECRUITING

UPMC Hillman Cancer Center, Pittsburgh

20007

RECRUITING

Georgetown University Medical Center, Washington D.C.

20133

RECRUITING

Fondazione IRCCS Istituto Nazionale dei tumori, Milan

20162

RECRUITING

ASST Grande Ospedale Metropolitano Niguarda, Milan

21079

RECRUITING

Centre Georges François Leclerc, Dijon

22031

RECRUITING

NEXT Oncology Virginia, Fairfax

28034

RECRUITING

Hospital Universitario Ramon y Cajal, Madrid

28040

RECRUITING

Hospital Clinico San Carlos, Madrid

RECRUITING

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28041

RECRUITING

Hospital Universitario 12 de Octubre, Madrid

29011

RECRUITING

Hospital Regional Universitario de Malaga - Hospital Civil, Málaga

31008

RECRUITING

Clinica Universidad de Navarra, Pamplona

31059

RECRUITING

Oncopole Claudius Regaud, Toulouse

32086

RECRUITING

Cancer Specialists of North Florida, Saint Augustine

33000

RECRUITING

EDOG - Institut Bergonié, Bordeaux

33322

RECRUITING

Boca Raton Clinical Research Associates, Plantation

33612

RECRUITING

H Lee Moffitt Cancer Center and Research Institute, Tampa

34376

RECRUITING

Lungenfachklinik Immenhausen, Immenhausen

38120

RECRUITING

Baptist Medical Center, Memphis

41014

RECRUITING

Hospital Universitario Virgen del Rocio - PPDS, Seville

44093

RECRUITING

CHU de Nantes, Nantes

44106

RECRUITING

University Hospitals Cleveland Medical Center, Cleveland

46009

RECRUITING

Fundacion Instituto Valenciano de Oncologia, Valencia

46026

RECRUITING

Hospital Universitari i Politecnic La Fe de Valencia, Valencia

47014

RECRUITING

"Istituto Romagnolo per lo Studio dei Tumori Dino Amadori - IRST S.r.l", Meldola

47441

RECRUITING

Krankenhaus Bethanien Moers, Moers

48121

RECRUITING

Ospedale Santa Maria Delle Croci, Ravenna

48202

RECRUITING

Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion), Detroit

50937

RECRUITING

Uniklinik Köln, Cologne

59037

RECRUITING

CHU de Lille Institut Cœur Poumon, Lille

59102

RECRUITING

Intermountain Health - St. Vincent Frontier Cancer Center, Billings

60590

RECRUITING

Universitätsklinikum Frankfurt, Frankfurt am Main

68803

RECRUITING

Nebraska Cancer Specialist, Grand Island

69126

RECRUITING

Thoraxklinik Heidelberg gGmbH - Universitätsklinikum Heidelberg, Heidelberg

69500

RECRUITING

Hospices Civils de Lyon - Hôpital Louis Pradel, Bron

75005

RECRUITING

Institut Curie, Paris

75039

RECRUITING

NEXT Oncology Dallas, Irving

77030

RECRUITING

The University of Texas MD Anderson Cancer Center, Houston

91010

RECRUITING

City of Hope - Duarte, Duarte

92037

RECRUITING

University of California, San Diego Moores Cancer Center, San Diego

92150

RECRUITING

Hopital Foch, Suresnes

92618

RECRUITING

City of Hope - Lennar, Irvine

94158

RECRUITING

UCSF Medical Center - Mission Bay, San Francisco

94305

RECRUITING

Stanford University - Stanford Cancer Institute, Stanford

94805

RECRUITING

Institut Gustave Roussy, Villejuif

95817

RECRUITING

UC Davis, Davis Comprehensive Cancer Center, Sacramento

02215

RECRUITING

Dana Farber Cancer Institute, Boston

01307

RECRUITING

Universitätsklinikum Carl Gustav Carus an der TU Dresden, Dresden

00144

RECRUITING

IRCCS Instituto Nazionale tumori Ragina Elena, Rome

00168

RECRUITING

Fondazione Policlinico Universitario A Gemelli-Rome, Rome

2333 ZA

RECRUITING

Leiden University Medical Center, Leiden

08035

RECRUITING

Hospital Universitari Vall D' Hebron, Barcelona

08916

RECRUITING

ICO Badalona - H.U. Germans Trias i Pujol, Barcelona

All Listed Sponsors
lead

Revolution Medicines, Inc.

INDUSTRY