A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

710

Participants

Timeline

Start Date

February 27, 2024

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2029

Conditions
Solid Cancer
Interventions
DRUG

R-DXd

R-DXd will be administered as an intravenously (IV) infusion

DRUG

Gemcitabine

Gemcitabine will be administered as an IV infusion

DRUG

Paclitaxel

Paclitaxel will be administered as an IV infusion

DRUG

Topotecan

Topotecan will be administered as an IV infusion

DRUG

PLD

PLD will be administered as an IV infusion

Trial Locations (116)

5000

ACTIVE_NOT_RECRUITING

GenesisCare St Andrews Hospital, Adelaide

10016

RECRUITING

NYU Langone Health, New York

10065

RECRUITING

NHPP LHH, New York

10408

ACTIVE_NOT_RECRUITING

National Cancer Center, Goyang-si

11042

RECRUITING

Northwell Health, LLC PRIME, Lake Success

11217

ACTIVE_NOT_RECRUITING

Taipei Veterans General Hospital, Taipei

11501

RECRUITING

Perlmutter Cancer Center at NYU Langone Hospital- Long Island, Mineola

11706

RECRUITING

NHPP Imbert, Bay Shore

12967

RECRUITING

Oklahoma Cancer Specialists and Research Institute, Tulsa

20089

COMPLETED

Istituto Clinico Humanitas, Rozzano

22190

ACTIVE_NOT_RECRUITING

CARIO - Centre Armoricain de Radiothérapie, Imagerie médicale et Oncologie, Plérin

27607

RECRUITING

Duke Women's Cancer Care- Raleigh, Durham

27710

RECRUITING

Duke Cancer Center, Durham

28040

ACTIVE_NOT_RECRUITING

Hospital Universitario Clinico San Carlos, Madrid

29425

RECRUITING

Medical University of South Carolina (MUSC), Charleston

32746

RECRUITING

Florida Cancer Specialists, Lake Mary

33136

RECRUITING

Sylvester Cancer Center, Miami

33140

RECRUITING

Mount Sinai Comprehensive Cancer Center, Miami Beach

33146

RECRUITING

Sylvester Comprehensive Cancer Center at Lennar, Coral Gables

33324

RECRUITING

Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

40705

ACTIVE_NOT_RECRUITING

Taichung Veterans General Hospital, Taichung

41017

RECRUITING

St. Elizabeth Medical Center, Edgewood

43026

RECRUITING

Ohio State University Wexner Medical Center, Hilliard

46219

RECRUITING

Community MD Anderson Cancer Center- East, Indianapolis

46227

RECRUITING

Community MD Anderson Cancer Center- South, Indianapolis

46250

RECRUITING

Community Health Network - MD Anderson, Indianapolis

50005

ACTIVE_NOT_RECRUITING

Fakultni nemocnice Hradec Kralove, Hradec Králové

57104

RECRUITING

Sanford Cancer Center Gynecologic Oncology, Sioux Falls

63110

RECRUITING

Washington University School of Medicine Obstetrics and Gynecology, St Louis

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

75231

RECRUITING

Texas Oncology-Presbyterian Cancer Center Dallas, Dallas

75246

RECRUITING

Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas

76022

RECRUITING

Texas Oncology-Bedford, Bedford

76104

RECRUITING

Texas Oncology Paris, Fort Worth

77030

RECRUITING

Houston Methodist Hospital, Houston

RECRUITING

University of Texas - MD Anderson, Houston

77079

RECRUITING

Houston Area Locations- Sugar Land, Houston

RECRUITING

Houston Area Locations- West Houston, Houston

77384

RECRUITING

Houston Area Locations- Woodlands, Conroe

77573

RECRUITING

Houston Area Locations- League City, League City

98109

RECRUITING

University of Washington - Seattle Cancer Care Alliance, Seattle

99508

RECRUITING

Alaska Women's Cancer Care, Anchorage

200032

ACTIVE_NOT_RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

250117

ACTIVE_NOT_RECRUITING

Shandong Cancer Hospital, Jinan

310022

ACTIVE_NOT_RECRUITING

Zhejiang Cancer Hospital, Hangzhou

350015

ACTIVE_NOT_RECRUITING

Fujian Provincial Cancer Hospital, Fuzhou

400030

ACTIVE_NOT_RECRUITING

Chongqing Cancer Hospital, Chongqing

430079

ACTIVE_NOT_RECRUITING

Hubei Cancer Hospital, Wuhan

06520

RECRUITING

Yale University School of Medicine, New Haven

07652

RECRUITING

Valley Health System, Paramus

07666

RECRUITING

Holy Name, Teaneck

19104-4238

RECRUITING

Perelman School of Medicine at the University of Pennsylvania, Philadelphia

Unknown

ACTIVE_NOT_RECRUITING

GenesisCare North Shore (Oncology), St Leonards

ACTIVE_NOT_RECRUITING

McGill University Health Centre/Glen Site / Royal Victoria Hospital, Montreal

ACTIVE_NOT_RECRUITING

University Health Network - Princess Margaret Cancer Centre, Toronto

ACTIVE_NOT_RECRUITING

Beijing Cancer Hospital, Beijing

ACTIVE_NOT_RECRUITING

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou

ACTIVE_NOT_RECRUITING

Qilu Hospital of Shandong University, Jinan

ACTIVE_NOT_RECRUITING

Guangxi Medical University Cancer Hospital, Nanning

ACTIVE_NOT_RECRUITING

National Cheng Kung University Hospital, Tainan

ACTIVE_NOT_RECRUITING

Tianjin Medical University Cancer Institute & Hospital, Tianjin

ACTIVE_NOT_RECRUITING

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

ACTIVE_NOT_RECRUITING

Fakultni nemocnice Bulovka, Prague

ACTIVE_NOT_RECRUITING

Vseobecna fakultni nemocnice v Praze, Prague

ACTIVE_NOT_RECRUITING

Centre Francois Baclesse, Caen

ACTIVE_NOT_RECRUITING

Centre Georges François Leclerc, Dijon

ACTIVE_NOT_RECRUITING

Centre Leon Berard, Lyon

ACTIVE_NOT_RECRUITING

Institut Paoli Calmettes, Marseille

ACTIVE_NOT_RECRUITING

Institut du Cancer de Montpellier, Montpellier

ACTIVE_NOT_RECRUITING

Hôpital Privé du Confluent, Nantes

ACTIVE_NOT_RECRUITING

Groupe Hospitalier Diaconesses - Hôpital De La Croix Saint Simon, Paris

ACTIVE_NOT_RECRUITING

Institut Curie, Saint-Cloud

ACTIVE_NOT_RECRUITING

ICL Alexis Vautrin, Vandœuvre-lès-Nancy

ACTIVE_NOT_RECRUITING

Universitaetsklinikum Mannheim, Mannheim

ACTIVE_NOT_RECRUITING

IRCCS Centro di Riferimento Oncologico, Aviano

ACTIVE_NOT_RECRUITING

Azienda Ospedaliera Per Lemergenza Cannizzaro, Catania

ACTIVE_NOT_RECRUITING

Azienda Ospedaliera Universitaria Careggi, Florence

ACTIVE_NOT_RECRUITING

Humanitas San Pio X, Milan

ACTIVE_NOT_RECRUITING

IEO Istituto Europeo di Oncologia, Milan

ACTIVE_NOT_RECRUITING

Istituto Nazionale Tumori Fondazione G. Pascale, Napoli

ACTIVE_NOT_RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma

ACTIVE_NOT_RECRUITING

Ospedale Mauriziano Umberto I, Torino

ACTIVE_NOT_RECRUITING

Uniwersyteckie Centrum Kliniczne, Gdansk

ACTIVE_NOT_RECRUITING

Mazowiecki Szpital Wojewodzki w Siedlcach Sp z o o, Siedlce

ACTIVE_NOT_RECRUITING

Hospital Professor Doutor Fernando Fonseca, E.P.E., Amadora

ACTIVE_NOT_RECRUITING

CHA Bundang Medical Center, CHA University, Seongnam-si

ACTIVE_NOT_RECRUITING

Asan Medical Center, Seoul

ACTIVE_NOT_RECRUITING

Samsung Medical Center, Seoul

ACTIVE_NOT_RECRUITING

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

ACTIVE_NOT_RECRUITING

Hospital Clinic de Barcelona, Barcelona

ACTIVE_NOT_RECRUITING

Hospital Universitari Vall d'Hebron, Barcelona

ACTIVE_NOT_RECRUITING

Hospital Universitario Ciudad de Jaen, Jaén

ACTIVE_NOT_RECRUITING

Hospital Universitario 12 de Octubre, Madrid

ACTIVE_NOT_RECRUITING

Hospital Universitario La Paz, Madrid

ACTIVE_NOT_RECRUITING

Clinica Universidad de Navarra (MAD), Pamplona

ACTIVE_NOT_RECRUITING

Clinica Universidad de Navarra, Pamplona

ACTIVE_NOT_RECRUITING

Hospital Clínico Universitario Valencia, Valencia

ACTIVE_NOT_RECRUITING

Koo Foundation Sun Yat-Sen Cancer Center, Taipei

ACTIVE_NOT_RECRUITING

Chang Gung Memorial Hospital,Linkou, Taoyuan

ACTIVE_NOT_RECRUITING

Royal United Hospital, Bath

150 06

ACTIVE_NOT_RECRUITING

Fakultni nemocnice v Motole, Prague

104-0045

ACTIVE_NOT_RECRUITING

National Cancer Center Hospital, Chūōku

811-1395

ACTIVE_NOT_RECRUITING

NHO Kyushu Cancer Center, Fukuoka

350-1298

ACTIVE_NOT_RECRUITING

Saitama Medical University International Medical Center, Hidaka-shi

277-8577

ACTIVE_NOT_RECRUITING

National Cancer Center Hospital East, Kashiwa-shi

135-8550

ACTIVE_NOT_RECRUITING

Cancer Institute Hospital of JFCR, Kōtoku

105-8471

ACTIVE_NOT_RECRUITING

Jikei University Hospital, Minatoku

411-8777

ACTIVE_NOT_RECRUITING

Shizuoka Cancer Center, Nagaizumi-cho

464-8681

ACTIVE_NOT_RECRUITING

Aichi Cancer Center Hospital, Nagoya

951-8566

ACTIVE_NOT_RECRUITING

Niigata Cancer Center Hospital, Niigata

541-8567

ACTIVE_NOT_RECRUITING

Osaka International Cancer Institute, Osaka

060-8648

ACTIVE_NOT_RECRUITING

Hokkaido University Hospital, Sapporo

028-3695

ACTIVE_NOT_RECRUITING

Iwate Medical University Hospital, Shiwa-gun

03080

ACTIVE_NOT_RECRUITING

National University Hospital, Seoul

03722

ACTIVE_NOT_RECRUITING

Severance Hospital, Yonsei University Health System, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Daiichi Sankyo

INDUSTRY