Primary Graft Dysfunction, Pronation, Bilateral Lung Transplants

NACompletedINTERVENTIONAL
Enrollment

67

Participants

Timeline

Start Date

January 1, 2020

Primary Completion Date

April 30, 2023

Study Completion Date

November 15, 2023

Conditions
Lung TransplantPrimary Graft Dysfunction
Interventions
PROCEDURE

Supine positioning

According to our local protocol, until December 2021, all patients developing PGD \>1 after LT were monitored in supine position for at least 24 hours, aiming at optimizing mechanical ventilation settings and right ventricular function, before considering PP. Only in case of radiological worsening or reduction in PaO2/FiO2 ratio patients were turned prone, generally between 24 and 48 hours after the diagnosis ('late PP' group), otherwise they were maintained supine ('supine' group).

PROCEDURE

Early pronation

According to our local protocol, starting from January 2022, all patients developing PGD \>1 after LT were monitored in supine position for at least 24 hours, aiming at optimizing mechanical ventilation settings and right ventricular function, before considering PP. Only in case of radiological worsening or reduction in PaO2/FiO2 ratio patients were turned prone, generally between 24 and 48 hours after the diagnosis ('late PP' group), otherwise they were maintained supine ('supine' group).

PROCEDURE

Late pronation

According to our local protocol, until December 2021, all patients developing PGD \>1 after LT were monitored in supine position for at least 24 hours, aiming at optimizing mechanical ventilation settings and right ventricular function, before considering PP. Only in case of radiological worsening or reduction in PaO2/FiO2 ratio patients were turned prone, generally between 24 and 48 hours after the diagnosis ('late PP' group), otherwise they were maintained supine ('supine' group).

Trial Locations (1)

35126

Azienda Ospedaliera Università Padova, Padua

All Listed Sponsors
lead

University of Padova

OTHER

NCT06159933 - Primary Graft Dysfunction, Pronation, Bilateral Lung Transplants | Biotech Hunter | Biotech Hunter