Post Spinal Hemodynamic Changes in Aortic Stenosis and Mitral Regurgitation by VIS Index and Echocardiography

RecruitingOBSERVATIONAL
Enrollment

40

Participants

Timeline

Start Date

November 1, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2027

Conditions
Severe Aortic Valve StenosisSevere Mitral Valve Regurgitation
Interventions
PROCEDURE

Cardiac valve replacement surgery under high spinal anesthesia combined with light general anesthesia

Before induction of general anesthesia, a high spinal anesthesia will be given using 37.5 mg of 0.75% heavy bupivacaine with 20 mcg fentanyl and 250 mcg epimorphine in sitting position at the lumbar intervertebral spaces between the L2-3 or L3-4 vertebrae. Patients will lie supine immediately afterwards, and sensory loss to ice will be performed every 15 seconds. Subsequently, the patient will be placed in 15-degree Trendelenburg (ensured by clinometer). Following general anesthesia will be induced and trachea will be intubated after 5 ml of 4% lignocaine spray on vocal cords and trachea. Hemodynamics will be aimed at MAP between 65-100 mmHg and heart rate between 50-100 beats /min by use of various inotropic, inodilators and vasoactive cardiac drugs based on anesthesiologists' clinical judgement.

Trial Locations (1)

R2H 2A6

RECRUITING

Department of Anesthesiology, Perioperative and Pain Medicine, SBGH, Winnipeg

All Listed Sponsors
lead

University of Manitoba

OTHER