Evaluating a Comprehensive Multimodal Outpatient Rehabilitation Program for PASC Program to Improve Functioning of Persons Suffering From Post-COVID-19 Syndrome: A Randomized Controlled Trial

NAEnrolling by invitationINTERVENTIONAL
Enrollment

216

Participants

Timeline

Start Date

November 15, 2023

Primary Completion Date

September 30, 2025

Study Completion Date

March 30, 2026

Conditions
Post-Acute COVID-19Post-Acute COVID-19 SyndromePost-Acute COVID-19 InfectionLong COVIDLong Covid19DyspneaOrthostasisCognitive Impairment
Interventions
OTHER

Comprehensive Rehabilitation

Subjects will be given the option to undergo the comprehensive rehabilitation program including speech therapy and physical therapy. Progression through the rehabilitation program will be personalized and designed based on impairments identified during the comprehensive baseline assessment and previous sessions. Subjects will undergo 12 one- hour sessions over the course of six weeks. The exercise program will be graded and targeted to the person's physical capacity with the goal of slowly advancing the exercise duration or intensity to effect physiological strengthening and increased physical function.

OTHER

Augmented Usual Care

"Following randomization, subjects in the augmented usual care group will be given the results of their in-person baseline assessment as well as the WHO Guide Support for Rehabilitation Self-Management after COVID-19 Related Illness. This guide consists of ways to manage: breathlessness, difficulty with voice, eating, drinking and swallowing; problems with attention, memory and thinking clearly; limitations in activities of daily living, manage stress and mood dysfunction and advice for when to contact healthcare professionals. Follow-up interviews will assess process measures, including use of outpatient rehabilitation clinics, to examine possible contamination effects"

Trial Locations (1)

19145

Hospital of the University of Pennsylvania, Philadelphia

All Listed Sponsors
collaborator

Medical College of Wisconsin

OTHER

collaborator

National Institutes of Health (NIH)

NIH

lead

University of Pennsylvania

OTHER