A Phase I/II Study to Assess the Safety, Pharmacokinetics, and Anti-Tumor Activity of Oral HP518 in mCRPC Patients

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

84

Participants

Timeline

Start Date

December 26, 2023

Primary Completion Date

October 31, 2025

Study Completion Date

September 30, 2026

Conditions
Metastatic Castration-resistant Prostate Cancer
Interventions
DRUG

HP518 - Dose Escalation

Part 1: Dose escalation Daily oral dosage with the prescribed dose level based on Cohort

DRUG

HP518 - Dose Escalation

Part 1: Dose escalation Daily oral dosage with the prescribed dose level based on Cohort

DRUG

HP518 -Dose Expansion

Part 2: Dose expansion Daily oral dosage with the highest dose with acceptable toxicity (RP2D) based on data from Part 1.

Trial Locations (27)

Unknown

RECRUITING

The Second Hospital Of Anhui Medical University, Hefei

RECRUITING

Beijing Cancer Hospital, Beijing

RECRUITING

Beijing Friendship Hospital, Capital Medical University, Beijing

RECRUITING

Chongqing University Cancer Hospital, Chongqing

RECRUITING

The Second Affiliated Hospital Of Chongqing Medical University, Chongqing

NOT_YET_RECRUITING

The First Affiliated Hospital Of Xiamen Univeristy, Xiamen

RECRUITING

Lanzhou University Second Hospital, Lanzhou

RECRUITING

The Third Affiliated Hospital of Southern Medical University, Guangzhou

RECRUITING

The Affiliated Hospital Of Guizhou Medical University, Guiyang

RECRUITING

Henan Cancer Hospital, Zhengzhou

RECRUITING

Zhengzhou Central Hospital, Zhengzhou

RECRUITING

Tongji Hospital, Wuhan

RECRUITING

Hunan Cancer Hospital, Changsha

RECRUITING

The First Affiliated Hospital Of Nanchang University, Nanchang

RECRUITING

Liaoning Cancer Hospital & Institute, Shenyang

RECRUITING

Shandong Provincial Hospital, Jinan

RECRUITING

The Affiliated Hospital Of Qingdao University, Qingdao

RECRUITING

Yantai Yuhuangding Hospital, Yantai

RECRUITING

Shanghai Tenth People's Hospital, Shanghai

RECRUITING

The First Affiliated Hospital Of Xi'An Jiaotong Univeristy, Xi’an

RECRUITING

Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu

RECRUITING

West China Hospital Of Sichuan University, Chengdu

RECRUITING

The Affiliated Hospital Of Southwest Medical University, Luzhou

RECRUITING

Mianyang Central Hospital, Mianyang

RECRUITING

The Second Affiliated Hospital Of Kunming Medical University, Kunming

RECRUITING

The Affiliated Hospital Of School Of Medicine Of Ningbo University, Ningbo

RECRUITING

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

Sponsors
All Listed Sponsors
lead

Hinova Pharmaceuticals Inc.

INDUSTRY