Rotational Thromboelastometry [ROTEM] vs Thromboelastography [TEG] Guided Blood Component Use in Patients With Cirrhosis of Liver With Non-variceal Bleeding.

NARecruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

December 16, 2023

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2024

Conditions
Liver Cirrhosis
Interventions
DIAGNOSTIC_TEST

ROTEM

In ROTEM group if CT EXTEM \>80S FFP at dose of 10ml/kg or PCC 20-25IU/kg ,if MCF EXTEM \<35 and MCF FIBTEM \<8 CRYO or Fibrinogen concentrate, if MCF EXTEM\<35 and MCF FIBTEM \>8 Platelet, CL LY\>50 Trenaxemic acid

DIAGNOSTIC_TEST

Thromboelastography

Patients in the TEG group received blood components using the following triggers: FFP at a dose of 10 mL/kg of ideal body weight when reaction time (R time) was greater than 10 minutes; a single-donor apheresis platelet (SDAP) unit, which corresponds to approximately 6 to 8 pooled units of PLTs, transfused when the maximum amplitude (MA) was less than 55 mm; and cryoprecipitate (5 pooled units) transfused when the alpha angle was less than 45°.

Trial Locations (1)

110070

RECRUITING

Dr Saurav Paul, New Delhi

All Listed Sponsors
lead

Institute of Liver and Biliary Sciences, India

OTHER