Ketorolac and Pregabalin Effects on breaSt Cancer (KePreSt)

PHASE2RecruitingINTERVENTIONAL
Enrollment

112

Participants

Timeline

Start Date

May 12, 2025

Primary Completion Date

April 20, 2027

Study Completion Date

October 31, 2027

Conditions
Early-stage Breast CancerEstrogen-receptor-positive Breast Cancer
Interventions
PROCEDURE

Prospective data and sample collection

Core-needle biopsy of the breast (pre-treatment), surgical sample collection (post-treatment), extra collection of blood samples (pre- and post-treatment), measurements of adiposity, lifestyle questionaire

DRUG

Ketorolac 10 Mg Oral Tablet

Patients will receive 10 mg film-coated tablets of ketorolac tromethamine three times a day, for five days before the surgery

DRUG

Pregabalin 75mg

Patients will receive 75 mg of pregabalin hard capsule twice a day, for seven days before the surgery

DRUG

Omeprazole 20mg Capsule

Patients will receive 20 mg of omeprazole once a day on an empty stomach, for five days before the surgery

Trial Locations (1)

1170

RECRUITING

Institut Jules Bordet, Brussels

Sponsors
All Listed Sponsors
collaborator

KU Leuven

OTHER

lead

Jules Bordet Institute

OTHER