Liver and Spleen Stiffness Measured by TE and 2D-SWE for Diagnosis of CSPH in Patients With cACLD

RecruitingOBSERVATIONAL
Enrollment

150

Participants

Timeline

Start Date

December 1, 2023

Primary Completion Date

January 1, 2025

Study Completion Date

January 1, 2025

Conditions
Liver CirrhosisLiver FibrosisPortal Hypertension
Interventions
DIAGNOSTIC_TEST

Diagnostic Test: Transient elastography (TE) and 2D-shear wave elastography (2D-SWE)

"Index test: TE examination will be completed by experienced nurses, requiring fasting for more than 4 hours before the examination and an interval of no more than 1 week from the abdominal ultrasound and 2D-SWE examination. The report will be considered highly reliable only if IQR/med is ≤ 30%, at least 10 successful acquisitions are obtained, and the success rate is at least 60%. Abdominal ultrasound and 2D-shear wave elastography (2D-SWE) will be completed by a sonographer, the interval between ultrasonic examination and laboratory tests should be less than a week, and the patients should fast for at least 4 hours before the examination.~Reference standard: Hepatic venous pressure gradient (HVPG) will be conducted by experienced interventionists. There should be a maximum interval of no more than 1 week between the HVPG and ultrasound examination, and patients should fast for at least 2 hours before undergoing HVPG."

Trial Locations (1)

519000

RECRUITING

The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai

All Listed Sponsors
lead

Fifth Affiliated Hospital, Sun Yat-Sen University

OTHER