A Study of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-naïve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

190

Participants

Timeline

Start Date

December 21, 2023

Primary Completion Date

March 13, 2027

Study Completion Date

June 3, 2027

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG

Repotrectinib

Specified dose on specified days

DRUG

Crizotinib

Specified dose on specified days

Trial Locations (122)

0

Local Institution - 0085, Sakarya

1121

Local Institution - 0135, Budapest

1210

Local Institution - 0041, Vienna

1280

Local Institution - 0092, Ciudad Autónoma de Buenos Aires

1431

Local Institution - 0106, Buenos Aires

5000

Local Institution - 0093, Córdoba

5404

Kantonspital Baden, Baden

10016

Local Institution - 0134, New York

11501

Local Institution - 0210, Mineola

13125

Evangelische Lungenklinik Berlin, Berlin

13620

Seoul National University Bundang Hospital, Seongnam

15006

Local Institution - 0141, A Coruña

15706

Local Institution - 0138, Santiago de Compostela

20133

Local Institution - 0152, Milan

20900

Local Institution - 0149, Monza

21079

Local Institution - 0109, Dijon

26121

Local Institution - 0074, Oldenburg

26504

Local Institution - 0154, Pátrai

28041

Local Institution - 0137, Madrid

28222

Local Institution - 0139, Majadahonda

28644

Local Institution - 0062, Cheongju-si

29011

Local Institution - 0142, Málaga

33081

Local Institution - 0151, Aviano

33600

Local Institution - 0055, Pessac

34214

Local Institution - 0087, Istanbul

34376

Lungenfachklinik Immenhausen, Immenhausen

34440

T.C. Saglik Bakanligi Turkiye Kamu Hastaneleri Kurumu - Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Istanbul

34899

Local Institution - 0083, Istanbul

38700

Local Institution - 0058, La Tronche

41013

Local Institution - 0144, Seville

44800

Local Institution - 0189, Saint-Herblain

46026

Local Institution - 0143, Valencia

50309

Local Institution - 0221, Des Moines

50937

Universitaetsklinikum Koeln, Cologne

55131

Marienhaus Klinikum Mainz, Mainz

67091

Local Institution - 0059, Strasbourg

69310

Local Institution - 0060, Pierre-Bénite

73730

Klinikum Esslingen, Esslingen am Neckar

75014

Local Institution - 0056, Paris

76031

Local Institution - 0057, Rouen

80131

Local Institution - 0150, Naples

82131

Asklepios Klinik Gauting GmbH, Gauting

97074

Klinikum Würzburg Mitte, Würzburg

98405

Local Institution - 0214, Tacoma

100142

Local Institution - 0168, Beijing

110029

Local Institution - 0218, New Delhi

110085

Local Institution - 0076, New Delhi

122001

Local Institution - 0044, Gurugram

130012

Local Institution - 0178, Changchun

150000

Local Institution - 0171, Harbin

200030

Local Institution - 0164, Shanghai

200032

Local Institution - 0179, Shanghai

200746

Local Institution - 0031, Craiova

210029

Local Institution - 0193, Nanjing

250000

Local Institution - 0186, Jinan

310022

Local Institution - 0175, Hangzhou

330006

Local Institution - 0202, Nanchang

361003

Local Institution - 0169, Xiamen

380054

Local Institution - 0102, Ahmedabad

380060

Local Institution - 0118, Ahmedabad

400015

Local Institution - 0122, Cluj-Napoca

400042

Local Institution - 0185, Chongqing

410000

Local Institution - 0184, Changsha

411001

Local Institution - 0045, Pune

411004

Local Institution - 0049, Pune

430079

Local Institution - 0181, Wuhan

450003

Local Institution - 0166, Zhengzhou

510120

Local Institution - 0180, Guangzhou

530000

Local Institution - 0194, Nanning

560017

Local Institution - 0082, Bengaluru

610044

Local Institution - 0177, Chengdu

700106

Local Institution - 0067, Iași

710061

Local Institution - 0183, Xi'an

2418515

Local Institution - 0173, Yokohama

2520598

Local Institution - 0096, Viña del Mar

7500921

Fundacion Arturo Lopez Perez (FALP), Santiago

9800873

Sendai Kosei Hospital, Sendai

14784400

Local Institution - 0029, Barretos

15090000

Local Institution - 0037, São José do Rio Preto

02114

Local Institution - 0075, Boston

02215

Local Institution - 0201, Boston

C1426ANZ

Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires

C1199ABB

Local Institution - 0091, ABB

C1417DTB

Local Institution - 0207, Buenos Aires

30380-490

Local Institution - 0073, Belo Horizonte

90110-270

Local Institution - 0033, Porto Alegre

90610-000

Local Institution - 0034, Porto Alegre

01308-060

Local Institution - 0209, São Paulo

01321-001

Local Institution - 0147, São Paulo

22061-080

Local Institution - 0098, Rio de Janeiro

22250-905

Local Institution - 0108, Rio de Janeiro

01401-002

Local Institution - 0032, São Paulo

05652-900

Local Institution - 0114, São Paulo

M5G 2M9

Local Institution - 0002, Toronto

G8Z 3R9

Local Institution - 0123, Trois-Rivières

01307

Local Institution - 0035, Dresden

115 27

Local Institution - 0153, Athens

124 62

Local Institution - 0155, Chaïdári

540 07

"Theagenio Cancer Hospital of Thessaloniki", Thessaloniki

00144

Local Institution - 0148, Rome

466-8560

Local Institution - 0190, Nagoya

277-8577

Local Institution - 0132, Kashiwa

791-0280

Local Institution - 0174, Matsuyama

060-8648

Local Institution - 0163, Sapporo

113-8677

Tokyo Metropolitan Komagome Hospital, Bunkyo Ku

683-8504

Local Institution - 0159, Yonago

811-1395

Local Institution - 0195, Fukuoka

534-0021

Local Institution - 0160, Osaka

541-8567

Local Institution - 0167, Osaka

164-8541

Tokyo Metropolitan Police Hospital, Tokyo

1081 HV

Local Institution - 0216, Amsterdam

20-609

Local Institution - 0187, Lublin

10-357

Local Institution - 0196, Olsztyn

013812

Local Institution - 0030, Bucharest

022328

Local Institution - 0066, Bucharest

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Local Institution - 0063, Seoul

08035

Local Institution - 0140, Barcelona

06200

Local Institution - 0086, Yenimahalle

01140

Local Institution - 0088, Adana

06010

Local Institution - 0084, Ankara

Sponsors
All Listed Sponsors
collaborator

Zai Lab (Shanghai) Co., Ltd.

INDUSTRY

lead

Bristol-Myers Squibb

INDUSTRY