A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,200

Participants

Timeline

Start Date

December 13, 2023

Primary Completion Date

September 7, 2032

Study Completion Date

September 7, 2032

Conditions
Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Interventions
DRUG

Nemtabrutinib

Administered orally

DRUG

Ibrutinib

Administered orally

DRUG

Acalabrutinib

Administered orally

Trial Locations (189)

704

RECRUITING

National Cheng Kung University Hospital ( Site 1700), Tainan City

1474

RECRUITING

Akershus Universitetssykehus ( Site 0902), Lørenskog

1864

RECRUITING

Wits Clinical Research ( Site 1102), Johannesburg

2025

RECRUITING

Aotearoa Clinical Trials ( Site 3201), Auckland

2065

COMPLETED

Royal North Shore Hospital ( Site 2806), St Leonards

2800

RECRUITING

AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 0205), Mechelen

3000

RECRUITING

UZ Leuven-Hematology ( Site 0200), Leuven

3103

RECRUITING

Sykehuset i Vestfold ( Site 0903), Tønsberg

3240

RECRUITING

Waikato Hospital-Haematology ( Site 3202), Hamilton

4000

RECRUITING

Roskilde Sygehus-Department of Hematology ( Site 0402), Roskilde

5000

RECRUITING

Odense Universitetshospital-Department of Hematology ( Site 0401), Odense C

7100

RECRUITING

Antalya Egitim ve Arastırma Hastanesi ( Site 1409), Antalya

7580

RECRUITING

Haemalife ( Site 1105), Kuilsriver

7800

RECRUITING

Constantiaberg Haematology ( Site 1106), Plumstead

7925

RECRUITING

Groote Schuur Hospital-Clinical Haematology ( Site 1100), Cape Town

9000

RECRUITING

Aalborg Universitetshospital, Syd ( Site 0403), Aalborg

10048

RECRUITING

National Taiwan University Hospital ( Site 1701), Taipei

10330

RECRUITING

Chulalongkorn University ( Site 1802), Bangkok

10450

RECRUITING

Hospital Pulau Pinang ( Site 1602), George Town

10700

RECRUITING

Faculty of Medicine Siriraj Hospital-Division of Hematology, Department of Medicine ( Site 1801), Bangkok

10707

RECRUITING

Onkologische Schwerpunktpraxis Kurfuerstendamm ( Site 0600), Berlin

14263

RECRUITING

Roswell Park Cancer Institute ( Site 0023), Buffalo

15073

RECRUITING

Clínica Anglo Americana ( Site 2701), Lima

17403

RECRUITING

Cancer Care Associates Of York ( Site 0005), York

19008

RECRUITING

Consultants in Medical Oncology and Hematology (CMOH) ( Site 8002), Broomall

22030

RECRUITING

Trakya University-Balkan Onkoloji Hastanesi ( Site 1403), Edirne

22031

RECRUITING

Inova Schar Cancer Institute ( Site 0015), Fairfax

22903

RECRUITING

University of Virginia Cancer Center ( Site 0040), Charlottesville

23298

RECRUITING

Virginia Commonwealth University (VCU) Medical Center ( Site 0030), Richmond

27534

RECRUITING

Southeastern Medical Oncology Center ( Site 0049), Goldsboro

28207

RECRUITING

Oncology Specialists of Charlotte ( Site 0054), Charlotte

28222

RECRUITING

HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA ( Site 1208), Majadahonda

28223

RECRUITING

HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 1209), Pozuelo de Alarcón

33305

RECRUITING

Chang Gung Medical Foundation-Linkou Branch ( Site 1703), Taoyuan District

33401

RECRUITING

Florida Cancer Specialists - East ( Site 7002), West Palm Beach

33901

RECRUITING

Florida Cancer Specialists - South ( Site 7001), Fort Myers

34214

RECRUITING

Mega Medipol ( Site 1412), Istanbul

34381

RECRUITING

Sisli Florence Nightingale Hastanesi ( Site 1411), Istanbul

34711

RECRUITING

Clermont Oncology Center ( Site 0046), Clermont

34899

RECRUITING

Marmara Universitesi Pendik Egitim Arastirma Hastanesi ( Site 1408), Istanbul

35100

RECRUITING

Ege Universitesi Hastanesi ( Site 1404), Izmir

36604

RECRUITING

USA Mitchell Cancer Institute ( Site 0014), Mobile

37007

RECRUITING

Hospital Universitario de Salamanca - Complejo Asistencial U-Servicio de Hematologia ( Site 1201), Salamanca

37203

RECRUITING

TENNESSEE ONCOLOGY ( Site 0031), Nashville

37404

RECRUITING

Tennessee Oncology-Chattanooga ( Site 0045), Chattanooga

38320

RECRUITING

hospital universitario de canarias ( Site 1205), San Cristóbal de La Laguna

41017

RECRUITING

Saint Elizabeth Healthcare ( Site 0041), Edgewood

41063

RECRUITING

Kliniken Maria Hilf ( Site 0603), Mönchengladbach

46845

RECRUITING

Parkview Research Center at Parkview Regional Medical Center ( Site 0002), Fort Wayne

49503

RECRUITING

Corewell Health-Lemmon Holton Cancer Pavilion ( Site 0011), Grand Rapids

50200

RECRUITING

Maharaj Nakorn Chiang Mai Hospital ( Site 1800), Muang

52242

RECRUITING

University of Iowa-Holden Comprehensive Cancer Center ( Site 0017), Iowa City

53792

RECRUITING

University Hospital and UW Health Clinics ( Site 0006), Madison

55280

RECRUITING

Ondokuz Mays Üniversitesi ( Site 1410), Samsun

55416

RECRUITING

Regions Hospital ( Site 0042), Saint Louis Park

56068

RECRUITING

InVO Institut für Versorgungsforschung in der Onkologie ( Site 0606), Koblenz

59100

RECRUITING

University Malaya Medical Centre ( Site 1604), Lembah Pantai

64132

RECRUITING

MidAmerica Cancer Care, LLC ( Site 0043), Kansas City

65000

RECRUITING

Naresuan University Hospital ( Site 1804), Muang

75702

RECRUITING

Texas Oncology - Northeast Texas ( Site 8012), Tyler

76104

RECRUITING

The Center for Cancer and Blood Disorders ( Site 0032), Fort Worth

78217

RECRUITING

Texas Oncology - San Antonio ( Site 8006), San Antonio

78705

RECRUITING

Texas Oncology - Central/South Texas ( Site 8008), Austin

80218

RECRUITING

Saint Joseph Hospital ( Site 0026), Denver

80401

RECRUITING

Lutheran Medical Center ( Site 0027), Golden

81501

RECRUITING

Intermountain Health St. Mary's Regional Hospital ( Site 0025), Grand Junction

83301

RECRUITING

Chang Gung Memorial Hospital at Kaohsiung-Division of Hematology and Oncology ( Site 1702), Kaohsiung City

84036

RECRUITING

VK&K Studien GbR ( Site 0607), Landshut

86301

RECRUITING

Arizona Oncology Associates - NAHOA ( Site 8007), Prescott

88586

RECRUITING

Queen Elizabeth Hospital ( Site 1603), Kota Kinabalu

89081

RECRUITING

Universitaetsklinikum Ulm. ( Site 0601), Ulm

90110

RECRUITING

Songklanagarind hospital ( Site 1803), Hat Yai

94704

RECRUITING

Alta Bates Summit Medical Center ( Site 0004), Berkeley

99208

RECRUITING

Medical Oncology Associates, PS (dba Summit Cancer Centers) ( Site 0010), Spokane

100034

RECRUITING

Peking University First Hospital ( Site 2022), Beijing

100191

RECRUITING

Peking University Third Hospital-Hematology ( Site 2011), Beijing

130021

RECRUITING

The First Hospital of Jilin University-Hematology ( Site 2030), Changchun

200001

RECRUITING

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 2405), Valledupar

210029

RECRUITING

Jiangsu Province Hospital ( Site 2000), Nanjing

215000

RECRUITING

The First Affliated Hospital of Suzhou University ( Site 2027), Suzhou

221006

RECRUITING

The Affiliated Hospital of Xuzhou Medical College ( Site 2013), Xuzhou

230000

RECRUITING

Anhui Provincial Cancer Hospital ( Site 2001), Hefei

230002

RECRUITING

IMAT S.A.S ( Site 2401), Montería

250117

RECRUITING

Shandong Cancer Hospital ( Site 2003), Jinan

300060

RECRUITING

Tianjin Medical University Cancer Institute & Hospital-lymphoma ( Site 2019), Tianjin

301617

RECRUITING

Institute of hematology&blood disease hospital-Lymphoma ( Site 2005), Tianjin

310003

RECRUITING

The first Affiliated Hospital, Zhejiang University School of Medicine-Hematology ( Site 2002), Hangzhou

310022

RECRUITING

Zhejiang Cancer Hospital ( Site 2017), Hangzhou

330006

RECRUITING

The First Affiliated Hospital of Nanchang University ( Site 2023), Nanchang

330029

RECRUITING

Jiangxi Provincial Cancer Hospital ( Site 2009), Nanchang

400030

RECRUITING

Chongqing University Cancer Hospital ( Site 2041), Chongqing

410006

RECRUITING

Hunan Cancer Hospital ( Site 2020), Changsha

410011

RECRUITING

The Second Xiangya Hospital of Central South University ( Site 2010), Changsha

430000

RECRUITING

Tongji Hospital Affiliated to Tongji Medical College of HUST ( Site 2016), Wuhan

450008

RECRUITING

Henan Cancer Hospital-hematology department ( Site 2025), Zhengzhou

510515

RECRUITING

Southern Medical University Nanfang Hospital-Department of Hematopathology ( Site 2006), Guangzhou

510700

RECRUITING

Sun Yat-sen University Cancer Center ( Site 2028), Guangzhou

530200

RECRUITING

Guangxi Medical University Affiliated Tumor Hospital ( Site 2004), Nanning

545006

RECRUITING

Liuzhou People's Hospital ( Site 2029), Liuzhou

550004

RECRUITING

The Affiliated Hospital of Guizhou Medical University ( Site 2024), Guiyang

570311

RECRUITING

Hainan General Hospital ( Site 2018), Haikou

610041

RECRUITING

West China Hospital, Sichuan University-Head and Neck Oncology ( Site 2026), Chengdu

710068

RECRUITING

Shaanxi provincial people's hospital ( Site 2012), Xi'an

760032

RECRUITING

Fundacion Valle del Lili- CIC-Oncology CIC ( Site 2402), Santiago de Cali

830000

RECRUITING

Xinjiang Medical University Cancer Hospital - Urumqi ( Site 2014), Ürümqi

2201202

RECRUITING

Galilee Medical Center ( Site 1507), Nahariya

3109601

RECRUITING

Rambam Health Care Campus-Hematology and Bone Marrow Transplantation ( Site 1503), Haifa

3339419

RECRUITING

Bnai Zion Medical Center ( Site 1505), Haifa

4730056

RECRUITING

Wuhan Union Hospital ( Site 2015), Wuhan

4941492

RECRUITING

Rabin Medical Center ( Site 1504), Petah Tikva

5265601

RECRUITING

Sheba Medical Center-Hemato Oncology ( Site 1501), Ramat Gan

7033001

RECRUITING

Yitzhak Shamir Medical Center. ( Site 1506), Ẕerifin

7500921

RECRUITING

FALP-UIDO ( Site 2300), Santiago

7650568

RECRUITING

Clínica Alemana de Santiago-Unidad de Investigaciones ( Site 2306), Santiago

8420383

RECRUITING

Bradfordhill-Clinical Area ( Site 2310), Santiago

9112001

RECRUITING

Hadassah Medical Center-Hemato-Oncology ( Site 1500), Jerusalem

92093-0698

RECRUITING

Moores Cancer Center ( Site 0003), La Jolla

06360

RECRUITING

Eastern CT Hematology & Oncology Associates ( Site 0033), Norwich

07932

COMPLETED

Summit Medical Group Cancer Center ( Site 0007), Florham Park

07601

RECRUITING

John Theurer Cancer Center at Hackensack University Medical Center ( Site 0016), Hackensack

01409-001

RECRUITING

Hospital 9 De Julho ( Site 2206), São Paulo

20230-130

RECRUITING

Instituto Nacional de Câncer - INCA ( Site 2201), Rio de Janeiro

01321-001

RECRUITING

Hospital Paulistano-Americas Oncologia ( Site 2202), São Paulo

V1Y 5L3

RECRUITING

BC Cancer Kelowna ( Site 0112), Kelowna

V8R 6V5

RECRUITING

BC Cancer Victoria ( Site 0109), Victoria

L6R 3J7

RECRUITING

William Osler Health System ( Site 0103), Brampton

K1H 8L6

RECRUITING

The Ottawa Hospital - General Campus ( Site 0102), Ottawa

H4A 3J1

RECRUITING

McGill University Health Centre ( Site 0106), Montreal

G5L 5T1

COMPLETED

Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski ( Site 0100), Rimouski

030000

RECRUITING

Shanxi Cancer Hospital ( Site 2033), Taiyuan

500 05

RECRUITING

Fakultni nemocnice Hradec Kralove-IV. interni hematologicka klinika ( Site 0301), Hradec Králové

779 00

RECRUITING

Fakultni nemocnice Olomouc ( Site 0303), Olomouc

128 08

RECRUITING

Vseobecna fakultni nemocnice v Praze-I. Interní klinika - klinika hematologie ( Site 0302), Prague

06120

RECRUITING

Universitätsklinikum Halle ( Site 0604), Halle

106 76

RECRUITING

Evangelismos General Hospital of Athens ( Site 0700), Athens

115 26

RECRUITING

"General Hospital of Athens Laiko ( Site 0704)", Athens

681 00

RECRUITING

University Hospital of Alexandroupolis ( Site 0701), Alexandroupoli

455 00

RECRUITING

University Hospital of Ioannina ( Site 0702), Ioannina

Unknown

RECRUITING

Queen Mary Hospital ( Site 3300), Hong Kong

466-8560

ACTIVE_NOT_RECRUITING

Nagoya University Hospital ( Site 1907), Nagoya

371-8511

ACTIVE_NOT_RECRUITING

Gunma University Hospital ( Site 1903), Maebashi

060-8648

ACTIVE_NOT_RECRUITING

Hokkaido University Hospital ( Site 1900), Sapporo

650-0047

ACTIVE_NOT_RECRUITING

Kobe City Medical Center General Hospital ( Site 1910), Kobe

980-8574

ACTIVE_NOT_RECRUITING

Tohoku University Hospital ( Site 1901), Sendai

589-8511

ACTIVE_NOT_RECRUITING

Kindai University Hospital ( Site 1909), Sayama

693-8501

ACTIVE_NOT_RECRUITING

Shimane University Hospital ( Site 1911), Izumo

135-8550

ACTIVE_NOT_RECRUITING

Cancer Institute Hospital of JFCR ( Site 1906), Koto

260-8717

ACTIVE_NOT_RECRUITING

Chiba Cancer Center ( Site 1905), Chiba

812-8582

RECRUITING

Kyushu University Hospital ( Site 1914), Fukuoka

730-0052

ACTIVE_NOT_RECRUITING

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital ( Site 1913), Hiroshima

700-8558

ACTIVE_NOT_RECRUITING

Okayama University Hospital ( Site 1912), Okayama

543-8555

ACTIVE_NOT_RECRUITING

Japanese Red Cross Osaka Hospital ( Site 1908), Osaka

990-9585

ACTIVE_NOT_RECRUITING

Yamagata University Hospital ( Site 1902), Yamagata

03100

RECRUITING

Centro de Infusion Superare ( Site 2602), Mexico City

RECRUITING

Health Pharma Professional Research S.A. de C.V: ( Site 2608), Mexico City

0622

RECRUITING

North Shore Hospital-Department of Haematology ( Site 3200), Auckland

0372

RECRUITING

Oslo Universitetssykehus Rikshospitalet-Avdeling for blodsykdommer ( Site 0901), Oslo

054

RECRUITING

Centro Medico Monte Carmelo-Oncology ( Site 2706), Arequipa

30-727

RECRUITING

Pratia MCM Krakow ( Site 1007), Krakow

20-081

RECRUITING

Uniwersytecki Szpital Kliniczny nr 1 w Lublinie-Oddział Hematoonkologii-Transplantacji Szpiku i Chem ( Site 1006), Lublin

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Kilinka Onkologii I Hematologii ( Site 1004), Warsaw

80-214

RECRUITING

Uniwersyteckie Centrum Kliniczne-Klinika Hematologii i Transplantologii ( Site 1011), Gdansk

76-200

RECRUITING

Wojewódzki Szpital Specjalistyczny im. J. Korczaka w Słupsku-Oddział Hematologii i Transplantacji ( Site 1013), Słupsk

44-101

RECRUITING

Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1000), Gliwice

40-519

RECRUITING

Pratia Onkologia Katowice ( Site 1009), Katowice

10-228

RECRUITING

Samodzielny Publiczny Zakład Opieki Zdrowotnej MSWiA w Olsztynie-Oddzial Kliniczny Hematologii ( Site 1005), Olsztyn

1099-023

RECRUITING

Instituto Português de Oncologia de Lisboa Francisco Gentil ( Site 3103), Lisbon

1400-038

RECRUITING

Champalimaud Foundation ( Site 3102), Lisbon

4434-502

RECRUITING

Unidade Local de Saude Gaia/Espinho - Hospital Eduardo Santos Silva ( Site 3107), Vila Nova de Gaia

1449-005

RECRUITING

Unidade Local de Saude Lisboa Ocidental - Hospital de São Francisco Xavier ( Site 3104), Lisbon

1649-035

RECRUITING

Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 3106), Lisbon

4200-072

RECRUITING

Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 3100), Porto

0181

RECRUITING

Netcare Pretoria East Hospital-Alberts Cellular Therapy ( Site 1101), Pretoria

08908

RECRUITING

Institut Català d'Oncologia - L'Hospitalet-Haematology Department ( Site 1207), L'Hospitalet Del Llobregat

08036

RECRUITING

HOSPITAL CLÍNIC DE BARCELONA ( Site 1202), Barcelona

08035

RECRUITING

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1206), Barcelona

171 64

RECRUITING

Karolinska Universitetssjukhuset Solna ( Site 1302), Stockholm

06100

RECRUITING

Ankara Universitesi Tip Fakultesi Hastanesi-hematology ( Site 1401), Ankara

06800

RECRUITING

Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1407), Ankara

BS10 5NB

COMPLETED

Southmead Hospital ( Site 3010), Bristol

LA1 4RP

RECRUITING

Royal Lancaster Infirmary ( Site 3012), Lancaster

EC1A 7BE

RECRUITING

St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 3006), London

OX3 7LE

RECRUITING

The Churchill Hospital ( Site 3007), Oxford

BS32 4SY

RECRUITING

GenesisCare - Bristol ( Site 3011), Bristol

CB8 7XN

RECRUITING

GenesisCare - Cambridge ( Site 3001), Newmarket

SL4 3HD

RECRUITING

GenesisCare - Windsor ( Site 3002), Windsor

EN5 3DJ

RECRUITING

Barnet Hospital ( Site 3005), Barnet

LS9 7TF

RECRUITING

St James's University Hospital ( Site 3004), Leeds

NG5 1PB

RECRUITING

City Hospital, Nottingham University Hospitals NHS Trust ( Site 3003), Nottingham

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY