Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

710

Participants

Timeline

Start Date

December 6, 2023

Primary Completion Date

January 10, 2028

Study Completion Date

January 10, 2028

Conditions
Endometrial Cancer
Interventions
BIOLOGICAL

Sacituzumab tirumotecan

4 mg/kg of sacituzumab tirumotecan by IV infusion

DRUG

Doxorubicin

60 mg/m\^2 of doxorubicin by IV Infusion

DRUG

Paclitaxel

80 mg/m\^2 of paclitaxel by IV infusion

DRUG

Nab-paclitaxel

100 mg/m\^2 of nab-paclitaxel by IV infusion

Trial Locations (242)

1090

Medizinische Universität Wien ( Site 1202), Vienna

2065

GenesisCare North Shore ( Site 1103), St Leonards

2148

Blacktown Hospital ( Site 1101), Sydney

2730

Herlev and Gentofte Hospital-Department of Oncology ( Site 1801), Copenhagen

3000

UZ Leuven-Gynecologic Oncology ( Site 1301), Leuven

3002

Epworth Freemasons ( Site 1104), East Melbourne

3010

Inselspital Bern-Oncology ( Site 3801), Bern

3199

Frankston Hospital ( Site 1105), Frankston

4011

Stavanger Universitetssykehus ( Site 3103), Stavanger

4029

Royal Brisbane and Women's Hospital ( Site 1102), Brisbane

4031

University Hospital Basel-Gynecology & Gynecologic Oncology ( Site 3808), Basel

4615

Sorlandet Sykehus Kristiansand ( Site 3104), Kristiansand

5000

CHU UCL Namur/Site Sainte Elisabeth-Trial Office ( Site 1304), Namur

6020

Medizinische Universitaet Innsbruck-Univ.-Klinik f. Gynäkologie und Geburtshilfe ( Site 1201), Innsbruck

6500

Ospedale Regionale Bellinzona e Valli ( Site 3802), Bellinzona

7000

Kantonsspital Graubünden-Medizin ( Site 3803), Chur

8200

Aarhus Universitetshospital, Skejby ( Site 1802), Aarhus

8800

AZ Delta vzw-Oncology ( Site 1302), Roeselare

9000

AZ Maria Middelares-IKG ( Site 1305), Ghent

UZ Gent-Medical oncology ( Site 1303), Ghent

9038

Universitetssykehuset Nord-Norge HF ( Site 3101), Tromsø

10016

Laura and Isaac Perlmutter Cancer Center ( Site 4106), New York

10029

Icahn School of Medicine at Mount Sinai-Department of Obstetrics, Gynecology, and Reproductive Scie ( Site 4128), New York

10060

Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'O-Day Hospital Oncologico Multidisciplin ( Site 2613), Candiolo

10128

Ospedale Mauriziano-Ginecologia e Ostetricia ( Site 2608), Torino

11215

New York - Presbyterian Brooklyn Methodist Hospital ( Site 4134), Brooklyn

11501

Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 4156), Mineola

11795

Good Samaritan Hospital Medical Center ( Site 4139), West Islip

11819

Higiea Oncologia ( Site 2905), Mexico City

12808

Vseobecna fakultni nemocnice v Praze-Gynekologicko-porodnicka klinika 1.LF a VFN ( Site 1705), Prague

13353

Charité Campus Virchow-Klinikum ( Site 2102), Berlin

13620

Seoul National University Bundang Hospital-Obstetrics and Gynecology ( Site 3505), Seongnam

14004

Hospital Universitario Reina Sofia-Oncologia Medica ( Site 3601), Córdoba

15244

AHN West Penn Hospital-Gynecologic Oncology ( Site 4111), Pittsburgh

17007

Institut Català d'Oncologia (ICO) - Girona-Oncología Médica ( Site 3606), Girona

19090

Asplundh Cancer Pavilion ( Site 4107), Willow Grove

19107

Sidney Kimmel Cancer Center - Jefferson Health ( Site 4157), Philadelphia

20010

MedStar Washington Hospital Center ( Site 4108), Washington D.C.

20089

Istituto Clinico Humanitas-U.O di Oncologia medica ed Ematologia ( Site 2610), Rozzano

20133

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Chirurgia Ginecologica ( Site 2605), Milan

20141

Istituto Europeo di Oncologia IRCCS ( Site 2607), Milan

20159

Humanitas San Pio X Hospital ( Site 2614), Milan

20520

Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1903), Turku

22185

Skånes Universitetssjukhus Lund ( Site 3702), Lund

22190

Centre Armoricain de Radiotherapie Imagerie medicale et Oncologie ( Site 2001), Plérin

25000

CHU Besançon ( Site 2009), Besançon

25123

Azienda Ospedaliera Spedali Civili di Brescia-Obstetrics anf gynecology ( Site 2611), Brescia

27710

Duke Cancer Institute ( Site 4120), Durham

28027

Clinica Universidad de Navarra ( Site 3603), Madrid

28041

Hospital Universitario 12 de Octubre-Medical Oncology ( Site 3607), Madrid

28046

Hospital Universitario La Paz-Oncología Médica ( Site 3604), Madrid

30342

Northside Hospital ( Site 4112), Atlanta

30912

Augusta University ( Site 4116), Augusta

31059

Institut Claudius Regaud ( Site 2006), Toulouse

31904

Centricity Research Columbus Cancer Center ( Site 4154), Columbus

32804

AdventHealth Orlando-AdventHealth Medical Group Gynecological Oncology ( Site 4113), Orlando

33076

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 2002), Bordeaux

33081

CRO-IRCCS ( Site 2609), Aviano

33140

Mount Sinai Cancer Center ( Site 4117), Miami Beach

33401

Florida Cancer Specialists - East ( Site 7000), West Palm Beach

33520

Tampereen yliopistollinen sairaala ( Site 1901), Tampere

34298

Institut Regional du Cancer Montpellier ( Site 2008), Montpellier

35042

Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 2003), Rennes

36604

USA Mitchell Cancer Institute ( Site 4142), Mobile

37170

ROC37 ( Site 2010), Chambray-lès-Tours

38138

The West Clinic, PLLC dba West Cancer Center ( Site 4102), Germantown

40138

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlin-SSD Oncologia medica Addarii ( Site 2603), Bologna

41017

Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 4150), Edgewood

42123

Arcispedale Santa Maria Nuova ( Site 2612), Reggio Emilia

43210

The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 4125), Columbus

45136

Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung ( Site 2104), Essen

45219

University of Cincinnati Medical Center ( Site 4136), Cincinnati

46009

Fundación Instituto Valenciano de Oncología-Oncologico ( Site 3605), Valencia

46010

HOSPITAL CLINICO DE VALENCIA ( Site 3609), Valencia

46845

Parkview Research Center at Parkview Regional Medical Center ( Site 4132), Fort Wayne

57104

Sanford Cancer Center-Gynecologic Oncology ( Site 4121), Sioux Falls

58102

Sanford Health Roger Maris Cancer Center ( Site 4158), Fargo

59020

Centre Oscar Lambret ( Site 2007), Lille

59100

Pantai Hospital Kuala Lumpur-Cancer Centre ( Site 2803), Kuala Lumpur

University Malaya Medical Centre ( Site 2801), Kuala Lumpur

60201

NorthShore University HealthSystem - Evanston Hospital ( Site 4110), Evanston

63110

Washington University School of Medicine-Obstetrics & Gynecology ( Site 4146), St Louis

66220

Oncare - Unidad Valle ( Site 2906), San Pedro Garza García

66278

CENTRO MEDICO ZAMBRANO HELLION-Centro de Cáncer de Mama ( Site 2901), San Pedro Garza García

68020

Centro de Investigacion Clinica de Oaxaca ( Site 2907), Oaxaca City

68167

Universitätsmedizin Mannheim-Department of Obstetrics and Gynecology ( Site 2101), Mannheim

69373

CENTRE LEON BERARD ( Site 2004), Lyon Cedex08

70112

University Medical Center New Orleans ( Site 4133), New Orleans

70124

Instituto Tumori Giovanni Paolo II-ONCOLOGIA MEDICA ( Site 2604), Bari

70210

Kuopion Yliopistollinen Sairaala ( Site 1904), Kuopio

71103

TRIALS 365 ( Site 4105), Shreveport

72076

Universitaetsklinikum Tuebingen ( Site 2111), Tübingen

74078

SLK-Kliniken Heilbronn ( Site 2107), Heilbronn

75020

Groupe Hospitalier Diaconesses Croix Saint Simon ( Site 2005), Paris

77030

Houston Methodist Hospital-Obstetrics and Gynecology ( Site 4130), Houston

77380

Texas Oncology - Gulf Coast ( Site 8006), The Woodlands

78240

Texas Oncology - San Antonio ( Site 8005), San Antonio

80131

Istituto Nazionale Tumori IRCCS Fondazione Pascale-S.C. Oncologia Sperimentale Uro-Genitale ( Site 2602), Napoli

81337

Klinikum der Universität München Großhadern-Klinik und Poliklinik für Frauenheilkunde und Geburtshi ( Site 2109), Munich

85016

HonorHealth (HH) ( Site 8000), Phoenix

85711

Arizona Oncology Associates - HOPE ( Site 8002), Tucson

88212

MVZ für Hämatologie und Onkologie Ravensburg GmbH - Studienzentrum ( Site 2110), Ravensburg

89511

The Center of Hope ( Site 4109), Reno

90095

UCLA Hematology/Oncology - Westwood (Building 100)-Department of OBGYN, Division of Gynecologic Onc ( Site 4131), Los Angeles

94109

California Pacific Medical Center - Van Ness Campus ( Site 4129), San Francisco

99508

Alaska Womens Cancer Care ( Site 4122), Anchorage

100006

Beijing Obstetric and Gynecology Hospital ( Site 1653), Beijing

150000

Harbin Medical University Cancer Hospital-Gynecological Radiotherapy Department ( Site 1652), Harbin

168583

National Cancer Centre Singapore-Medical Oncology ( Site 3401), Singapore

200011

Obstetrics & Gynecology Hospital of Fudan University ( Site 1617), Shanghai

201204

Shanghai First Maternity and Infant Hospital-Gynecology department ( Site 1626), Shanghai

210006

Nanjing First Hospital ( Site 1649), Nanjing

230000

Second Affiliated hospital of Anhui Medical University-Oncology ( Site 1635), Hefei

276000

LinYi Cancer Hospital-Gastrology department ( Site 1630), Linyi

310006

The Affiliated Women's Hospital of Zhejiang University-Obstetrics and Gynecology ( Site 1609), Hangzhou

310022

Zhejiang Cancer Hospital-Oncology ( Site 1601), Hangzhou

317000

Taizhou Hospital of Zhejiang Province ( Site 1633), Linhai

325015

The First Affiliated Hospital of Wenzhou Medical University ( Site 1615), Wenzhou

330000

Jiangxi Maternal and Child Health Hospital-Oncology Department ( Site 1625), Nanchang

350014

Fujian Cancer Hospital-Gynecological Oncology Surgery ( Site 1627), Fuzhou

361003

The First Affiliated hospital of Xiamen University-Obstetrics and gynecology department ( Site 1613), Xiamen

410008

Xiangya Hospital Central South University-Gynecology ( Site 1603), Changsha

410013

Hunan Cancer Hospital ( Site 1623), Changsha

430022

Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 1621), Wuhan

430079

Hubei Cancer Hospital-Hubei Cancer Hospital ( Site 1607), Wuhan

450008

Henan Cancer Hospital ( Site 1618), Zhengzhou

450014

The Second Affiliated Hospital of Zhengzhou University ( Site 1640), Zhengzhou

510000

Sun Yat-sen Memorial Hospital, Sun Yat-sen University ( Site 1634), Guangzhou

510555

Sun Yat-sen University Cancer Center ( Site 1604), Guangzhou

515041

Cancer Hospital of Shantou University Medical College ( Site 1642), Shantou

524004

Affiliated Hospital of Guangdong Medical University ( Site 1614), Zhanjiang

530021

Guangxi Medical University Affiliated Tumor Hospital-Gynecological oncology ( Site 1622), Nanning

570311

Hainan General Hospital ( Site 1636), Haikou

610000

West China Second University Hospital, Sichuan University ( Site 1602), Chengdu

610042

Sichuan Cancer hospital-Oncology ( Site 1650), Chengdu

650107

Yunnan Province Cancer Hospital-Gynecology Department ( Site 1641), Kunming

830000

Xinjiang Medical University Cancer Hospital - Urumqi ( Site 1648), Ürümqi

3109601

Rambam Health Care Campus-Gyneco-oncology unit ( Site 2502), Haifa

4800827

James Lind Centro de Investigacion del Cancer ( Site 1504), Temuco

4941492

Rabin Medical Center ( Site 2505), Petah Tikva

5265601

Sheba Medical Center ( Site 2504), Ramat Gan

5810001

Edith Wolfson Medical Center ( Site 2501), Holon

6423906

Sourasky Medical Center ( Site 2506), Tel Aviv

7500653

Centro de Estudios Clínicos SAGA-CECSAGA ( Site 1505), Santiago

8330024

Pontificia Universidad Catolica de Chile ( Site 1503), Santiago

8420383

Bradfordhill-Clinical Area ( Site 1501), Santiago

9103102

Shaare Zedek Medical Center ( Site 2503), Jerusalem

89201260

Instituto Joinvilense de Hematologia e Oncologia ( Site 1353), Joinville

06511

Yale-New Haven Hospital-Smilow Cancer Hospital at Yale-New Haven ( Site 4114), New Haven

01605

University of Massachusetts Memorial Medical Center ( Site 4103), Worcester

07601

John Theurer Cancer Center at Hackensack University Medical Center ( Site 4118), Hackensack

07960

Atlantic Health System Morristown Medical Center ( Site 4135), Morristown

07666

Holy Name Medical Center ( Site 4115), Teaneck

02905

Women & Infants Hospital ( Site 4138), Providence

C1280AEB

Hospital Británico de Buenos Aires-Oncology ( Site 1002), Ciudad Autónoma de Buenos Aires

1426ANZ

Instituto Alexander Fleming-Alexander Fleming ( Site 1007), Buenos Aires

C1122AAL

Instituto Argentino de Diagnóstico y Tratamiento (IADT) ( Site 1008), Buenos Aires

C1118AAT

Hospital Aleman-Oncology ( Site 1001), Buenos Aires

C1417DTB

Instituto de Oncología Angel H. Roffo ( Site 1003), Buenos Aires

C1431FWO

Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 1004), Buenos Aires

F5300COE

Fundación CORI para la Investigación y Prevención del Cáncer ( Site 1006), La Rioja

65060-645

Hospital São Domingos ( Site 1365), São Luís

38408-150

Centro Oncologico do Triangulo ( Site 1360), Uberlândia

90560-032

Hospital Moinhos de Vento ( Site 1359), Porto Alegre

18060-105

Instituto de Ensino e Pesquisa ( Site 1355), Sorocaba

20775-001

Instituto de Educação, Pesquisa e Gestão em Saúde ( Site 1352), Rio de Janeiro

01232-010

Hospital Samaritano De Sao Paulo ( Site 1367), São Paulo

01509-010

A. C. Camargo Cancer Center ( Site 1351), São Paulo

04014-002

IBCC - Núcleo de Pesquisa e Ensino ( Site 1366), São Paulo

T2N 5G2

Arthur J.E. Child Comprehensive Cancer Centre ( Site 1413), Calgary

T6G 1Z2

Cross Cancer Institute ( Site 1414), Edmonton

V5Z 4E6

BC Cancer Vancouver ( Site 1415), Vancouver

L5M 2N1

Trillium Health Partners - Credit Valley Hospital ( Site 1410), Mississauga

G7H 5H6

CIUSSS- saguenay-Lac-Saint-Jean ( Site 1408), Chicoutimi

H1T 2M4

CIUSSS de l'Est-de-l'Île-de-Montréal ( Site 1405), Montreal

H2X 0C1

Centre Hospitalier de l'Université de Montréal ( Site 1403), Montreal

H4A 3J1

McGill University Health Centre ( Site 1404), Montreal

602 00

Fakultní Nemocnice Brno-Gynekologicko-porodnicka klinika ( Site 1704), Brno

708 52

Fakultni nemocnice Ostrava-Gynekologicko-porodnicka klinika ( Site 1703), Ostrava

741 01

Nemocnice AGEL Novy Jicin a.s.-Oddeleni radioterapie a onkologie ( Site 1706), Nový Jiín

779 00

Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 1702), Olomouc

100 34

Fakultni nemocnice Kralovske Vinohrady ( Site 1707), Prague

180 00

Fakultni nemocnice Bulovka-Gynekologicko-porodnicka klinika ( Site 1701), Prague

DK-2100

Rigshospitalet-Dept. of Oncology ( Site 1803), Copenhagen

00029

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 1902), Helsinki

01307

Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Frauenheilkunde und Gebur ( Site 2103), Dresden

263 35

Agios Andreas Hospital Patras ( Site 2201), Pátrai

115 28

Aretaieio Hospital Oncology Unit ( Site 2206), Athens

185 47

Metropolitan Hospital-2nd Oncology Dept ( Site 2202), Athens

151 23

Hygeia Hospital ( Site 2204), Marousi

T12 DC4A

Cork University Hospital ( Site 2402), Cork

D07 R2WY

Mater Misericordiae University Hospital ( Site 2403), Dublin

D08 E9P6

St. James's Hospital-Cancer clinical trials office ( Site 2401), Dublin

00161

AOU Policlinico Umberto I ( Site 2606), Rome

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Ginecologia Oncologica ( Site 2601), Roma

464-8681

Aichi Cancer Center ( Site 2714), Nagoya

791-0280

National Hospital Organization Shikoku Cancer Center ( Site 2705), Matsuyama

791-0295

Ehime University Hospital ( Site 2709), Tōon

830-0011

Kurume University Hospital ( Site 2703), Kurume

373-8550

Gunma Prefectural Cancer Center ( Site 2708), Otashi

060-8648

Hokkaido University Hospital ( Site 2707), Sapporo

305-8576

University of Tsukuba Hospital ( Site 2713), Tsukuba

028-3695

Iwate Medical University Hospital ( Site 2712), Shiwa-gun

951-8566

Niigata Cancer Center Hospital ( Site 2701), Niigata

350-1298

Saitama Medical University International Medical Center ( Site 2710), Hidaka

411-8777

Shizuoka Cancer Center ( Site 2716), Sunto-gun,

104-0045

National Cancer Center Hospital ( Site 2715), Chuo-ku

135-8550

Cancer Institute Hospital of JFCR ( Site 2706), Koto

142-8666

Showa Medical University Hospital ( Site 2719), Shinagawa

160-8582

Keio University Hospital ( Site 2702), Shinjuku

811-1395

National Hospital Organization Kyushu Cancer Center ( Site 2711), Fukuoka

890-8760

Kagoshima City Hospital ( Site 2717), Kagoshima

541-8567

Osaka International Cancer Institute ( Site 2718), Osaka

04700

COI Centro Oncologico Internacional S.A.P.I. de C.V. ( Site 2902), Coyoacán

6525 GA

Radboudumc-Medical Oncology ( Site 3003), Nijmegen

1081 HV

Amsterdam UMC - locatie VUmc ( Site 3004), Amsterdam

2333 ZA

Leids Universitair Medisch Centrum-Medical Oncology ( Site 3002), Leiden

0379

Oslo universitetssykehus, Radiumhospitalet ( Site 3102), Oslo

61-866

Wielkopolskie Centrum Onkologii im. Marii Skłodowskiej-Curie-Oddział Radioterapii i Onkologii Ginek ( Site 3202), Poznan

08-110

Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 3201), Siedlce

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Ginekologii Onkologicznej ( Site 3203), Warsaw

15-027

Bialostockie Centrum Onkologii-Oddzial Onkologii Ginekologicznej ( Site 3204), Bialystok

00717

Ad-Vance Medical Research-Research ( Site 3302), Ponce

00909

Pan American Center for Oncology Trials - Ciudadela ( Site 3301), San Juan

00935

UPR Comprehensive Cancer Center-Comprehensive Cancer Center Hospital ( Site 3304), San Juan

03080

Seoul National University Hospital ( Site 3502), Seoul

03722

Severance Hospital, Yonsei University Health System-Gynecologic cancer center ( Site 3503), Seoul

05505

Asan Medical Center-Division of Gynecologic Oncology, Dept. of Obstetrics & Gynecology ( Site 3501), Seoul

06351

Samsung Medical Center ( Site 3504), Seoul

08908

Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 3608), L'Hospitalet de Llobregat

08035

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 3602), Barcelona

171 76

Karolinska Universitetssjukhuset Solna ( Site 3701), Stockholm

BN2 1ES

University Hospitals Sussex NHS Foundation Trust ( Site 4006), East Sussex

DE22 3NE

Royal Derby Hospital ( Site 4007), Derby

SW3 6JJ

ROYAL MARSDEN HOSPITAL (CHELSEA)-Gynaecology Research Centre ( Site 4002), London

Royal Marsden Hospital (Sutton)-Gynaecology Unit ( Site 4010), London

TR1 3LJ

The Royal Cornwall Hospital ( Site 4009), Truro

NW1 2PG

University College London Hospital-Cancer Clinical Trials Unit ( Site 4004), London

SE1 9RT

Guy's & St Thomas' NHS Foundation Trust-Oncology & Haematology Clinical Trials ( Site 4008), London

W12 OHS

Hammersmith Hospital ( Site 4001), London

G12 0YN

The Beatson West of Scotland Cancer Centre ( Site 4005), Glasgow

m20 4bx

The Christie NHS Foundation Trust-Medical Oncology ( Site 4003), Manchester

All Listed Sponsors
collaborator

European Network for Gynaecological Oncological Trial groups(ENGOT)

UNKNOWN

collaborator

GOG Foundation

NETWORK

lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT06132958 - Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005) | Biotech Hunter | Biotech Hunter