A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema Compared to Semaglutide, Cagrilintide and Placebo

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

618

Participants

Timeline

Start Date

April 1, 2024

Primary Completion Date

September 24, 2025

Study Completion Date

November 6, 2025

Conditions
Chronic Kidney DiseaseType 2 DiabetesObesity
Interventions
DRUG

Cagrilintide

Participants will receive Cagrilintide subcutaneously.

DRUG

Semaglutide

Participants will receive semaglutide subcutaneously.

DRUG

Placebo

Participants will receive placebo matched to cagrilintide or placebo matched to semaglutide subcutaneously.

Trial Locations (119)

1032

Szent Margit Rendelőintézet Nonprofit Kft., Budapest

4025

Belinus Bt., Debrecen

4405

Borbánya Praxis E.Ü. Kft., Nyíregyháza

5700

Békés Megyei Központi Kórház, Gyula

6300

Fundación CESIM, Santa Rosa

6500

Lausmed Kft., Baja

7623

PTE-AOK II. Belgyogyaszati Klinika es Nephrologiai Centrum, Pécs

8600

Siófoki Kórház, Diabetológiai Szakrendelés, Siófok

10330

King Chulalongkorn Memorial Hospital, Bangkok

10400

Phramongkutklao Hospital, Bangkok

10700

Siriraj Hospital, Bangkok Noi

Siriraj Hospital, Bangkok

11501

NYU Langone Neph Associates, Mineola

11527

"Laiko General Hospital of Athens", Athens

Gen Hospital of Athens Laiko,1st Dpt. of Propaedeutic Inter, Athens

General hospital of Athens 'G.Gennimatas', Athens

12120

Thammasat Hospital, Klong Luang Pathum Thani

Thammasat University Hospital, Klong Luang

12203

Albany Medical College, Albany

14224

Southgate Medical Group, LLP, West Seneca

15009

Heritage Valley Medical Group Inc, Beaver

17562

Iatriko Athinon 'Palaiou Falirou', Athens

26504

General University Hospital of Patras,Nephrology clinic, Rio, Patra

27103

Brookview Hills Research Associates, LLC, Winston-Salem

28222

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda

28557

Carteret Medical Group, Morehead City

28562

Eastern Nephr Assoc, PLLC, New Bern

28922

Hospital Fundación Alcorcón, Alcorcón

29566

Main Street Physician's Care, Little River

31059

Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil-1, Toulouse

32003

Northeast Research Institute, Fleming Island

32804

Florida Hospital Translational Research Institute, Orlando

33130

Life Spring Research, Miami

35100

General Hospital of Lamia, Lamia

38320

Hospital Universitario de Canarias, Santa Cruz de Tenerife

43537

Ohio- Advanced Medical Research, Maumee

44800

Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec-1, Saint-Herblain

46010

Hospital Clinico Universitario de Valencia, Valencia

46383

Velocity Clin. Res Valparaiso, Valparaiso

48532

Elite Research Center, Flint

50200

Maharaj Nakorn Chiang Mai Hospital, Chiang Mai

51092

Centre Hospitalier Universitaire Reims-Hopital Maison Blanche, Reims

53144

Clinical Investigation Spec. Kenosha, Kenosha

54635

General Hospital of Thessaloniki 'G. Gennimatas, Thessaloniki

54642

"Ippokrateio G.H. of Thessaloniki", Thessaloniki

"General Hospital of Thessaloniki Ippokrateio", Thessaloniki

57010

"General Hospital of Thessaloniki G.Papanikolaou", Thessaloniki

68198

Univ. of Nebraska Medical Center_Omaha, Omaha

69200

Centre de Recherche Clinique Portes Du Sud, Vénissieux

71200

Groupe Sos Sante-Hopital Le Creusot-Hotel Dieu-1, Le Creusot

71500

Periphery University Hospital of Heraklion, Heraklion / Crete

77099

Southwest Houston Research Ltd, Houston

78212

Clinical Advancement Ctr, PLLC, San Antonio

78414

Osvaldo A. Brusco MD PA, Corpus Christi

86000

Centre Hospitalier Universitaire de Poitiers, Poitiers

91355

Desert Oasis Hlthcr Med Group, Palm Springs

91773

North America Research Institute, San Dimas

94520

John Muir Physicians Network, Concord

94583

NorCal Endocrinology and Internal Medicine, San Ramon

110002

Maulana Azad Medical College, Delhi

248001

Shri Mahant Indiresh Hospital, Dehradun

400012

Seth GS Medical College & KEM Hospital, Mumbai

520002

Sunrise Hospital, Vijayawada

522001

Endolife Specialty Hospitals, Guntur

560066

Lifecare Hospital and Research Centre, Bengaluru

600086

Madras Diabetes Research Foundation, Chennai

C1128 AAF

Mautalen Salud e investigación, CABA

B7600GNY

Centro de Investigaciones Médicas Mar del Plata, Mar del Plata

C1425AGC

Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli, Buenos Aires

X5006IKK

Centro Médico Privado San Vicente Diabetes, Córdoba

80440-020

Instituto Pró-Renal Brasil, Curitiba

90430-001

Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda., Porto Alegre

01228-200

CPCLIN - Centro de Pesquisas Clínicas, São Paulo

04038-002

Hospital do Rim e Hipertensao Fundacao Oswaldo Ramos, São Paulo

L6S 0C6

Centricity Research Brampton, Brampton

L4K 4M2

Centricity Research Vaughn Endocrinology, Concord

M9R 4E1

Centricity Research Etobicoke, Etobicoke

L8L 5G4

Hamilton Medical Rsrch Grp, Hamilton

N7T 4X3

Bluewater Clin Res Group Inc, Sarnia

M5G 2N2

UHN-Toronto General Hospital, Toronto

H7T 2P5

Ctr de rech Clin de Laval, Laval

H4N 2W2

Centre Medical Acadie, Montreal

GR-11527

"Laiko General Hospital of Athens", Athens

Gen Hospital of Athens Laiko,1st Dpt. of Propaedeutic Inter, Athens

General hospital of Athens 'G.Gennimatas', Athens

GR-41110

Univ Gen Hospital Larisa, Endocrinology & Metabolic Disease, Larissa

GR-26504

General University Hospital of Patras,Nephrology clinic, Pátrai

GR-54635

General Hospital of Thessaloniki 'G. Gennimatas, Thessaloniki

GR-54642

"Ippokrateio G.H. of Thessaloniki", Thessaloniki

GR-57010

"General Hospital of Thessaloniki G.Papanikolaou", Thessaloniki

963-8851

Seino Internal Medicine Clinic_Internal medicine, Koriyama-shi

721-0927

Nippon Kokan Fukuyama Hospital_Diabetology, Fukuyama-shi, Hiroshima

062-0007

Sasaki Internal Medicine, Hokkaido

331-0133

Nishiyamado Keiwa Hospital_Internal Medicine, Ibaraki

181-0013

Kanno Naika_Internal Medicine, Mitaka-shi, Tokyo

311-4153

Minami Akatsuka Clinic, Mito-shi, Ibaraki

103-0027

Tokyo-Eki Center-building Clinic_Internal Medicine, Tokyo

104-0031

Fukuwa Clinic_Internal Medicine, Tokyo

Fukuwa Clinic, Tokyo

15-351

Osteo Medic s.c. Artur Racewicz Jerzy Supronik, Bialystok

15-435

NZOZ Specjalistyczny Osrodek Internistyczno-Diabetologiczny Małgorzata Arciszewska, Bialystok

15-481

Kresmed Sp. z o. o., Bialystok

41-500

M2M Med. Sp. z o.o. Sp. j., Chorzów

M2M Med. Sp. z o.o. Sp. j., Chorzów

81-338

Pratia S.A., Gdynia

40-081

Pratia S.A., Katowice

90-132

Gabinet Lekarski Malgorzata Saryusz-Wolska, Lodz

10-117

Etyka Osrodek Badan Klinicznych Tomasz Pesta S.K.A., Olsztyn

61-251

Gaja Poradnie Lekarskie, Poznan

02-507

Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych I Administracji, Warsaw

52-416

Centrum Medyczne Oporow, Wroclaw

41-800

Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Szyszko, Zabrze

851 01

MEDISPEKTRUM s.r.o., Bratislava

040 01

HUMAN-CARE, s.r.o., Košice

Univerzitna nemocnica L. Pasteura Kosice, Košice

Vysokospecializovany odborny ustav geriatricky sv. Lukasa v Kosiciach, n.o., Košice

048 01

Tatratrial s.r.o., Rožňava

08035

Hospital Vall d'Hebron, Barcelona

08907

Hospital de Bellvitge, L'Hospitalet de Llobregat

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novo Nordisk A/S

INDUSTRY