MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

PHASE3RecruitingINTERVENTIONAL
Enrollment

765

Participants

Timeline

Start Date

December 13, 2023

Primary Completion Date

December 31, 2027

Study Completion Date

April 30, 2028

Conditions
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Interventions
BIOLOGICAL

NTLA-2001

NTLA-2001 (55mg) by IV infusion

DRUG

Placebo

Normal saline (0.9% NaCl) by IV infusion

Trial Locations (132)

10016

RECRUITING

New York University (NYU) School of Medicine - Langone Medical Center, New York

10032

RECRUITING

Columbia University Medical Center, New York

15212

RECRUITING

Allegheny General Hospital, Pittsburgh

15219

RECRUITING

University of Pittsburgh Medical Center, Pittsburgh

19104

RECRUITING

Penn Presbyterian Medical Center, Philadelphia

20010

RECRUITING

MedStar Washington Hospital Center - MedStar Heart and Vascular Institute, Washington D.C.

21287

RECRUITING

Johns Hopkins University, Baltimore

22042

RECRUITING

INOVA Fairfax Hospital, Falls Church

23298

RECRUITING

Virginia Commonwealth University - Department of Internal Medicine, Richmond

27710

RECRUITING

Duke University Medical Center, Durham

29425

RECRUITING

Medical University of South Carolina, Charleston

30322

RECRUITING

Emory University School of Medicine, Atlanta

32224

RECRUITING

Mayo Clinic - Jacksonville, Jacksonville

33331

RECRUITING

Cleveland Clinic of Florida, Weston

40536

RECRUITING

University of Kentucky Gill Heart Institute, Lexington

43214

RECRUITING

Ohio Health Research Institute, Columbus

44195

RECRUITING

Cleveland Clinic, Cleveland

46202

RECRUITING

Indiana University Health, Indianapolis

48109

RECRUITING

University of Michigan, Ann Arbor

48201

ACTIVE_NOT_RECRUITING

Barbara Ann Karmanos Cancer Institute, Detroit

55905

RECRUITING

Mayo Clinic, Rochester

60611

RECRUITING

Northwestern University, Chicago

64111

RECRUITING

St. Luke's Hospital, Kansas City

75093

RECRUITING

Baylor Scott and White - The Heart Hospital Baylor Plano, Plano

75201

RECRUITING

Baylor Scott & White Research Institute, Dallas

75390

RECRUITING

University of Texas Southwestern Medical Center, Dallas

77030

RECRUITING

Baylor College of Medicine, Houston

RECRUITING

Houston Methodist Hospital, Houston

80045

RECRUITING

University of Colorado Denver, Denver

85724

RECRUITING

University of Arizona, Tucson

90048

RECRUITING

Cedars-Sinai Medical Center, Los Angeles

90073

RECRUITING

Western Greater Los Angeles VA Medical Center, Los Angeles

92103

RECRUITING

University of California, San Diego (UCSD) - Medical Center, San Diego

94305

RECRUITING

Stanford University, Palo Alto

97239

RECRUITING

Oregon Health and Science University (OHSU), Portland

06510

RECRUITING

Yale University School of Medicine, New Haven

02115

RECRUITING

Brigham and Women's Hospital, Boston

02118

RECRUITING

Boston University School of Medicine, Boston

Unknown

RECRUITING

Fundacion Favalro, Buenos Aires

RECRUITING

Hospital Italiano de Buenos Aires, Buenos Aires

RECRUITING

ICBA, Buenos Aires

RECRUITING

Fundacion Favaloro, Ciudad Autonoma de Buenos Aire

RECRUITING

Hospital Italiano de Buenos Aires, Ciudad Autonoma de Buenos Aire

RECRUITING

Hospital Privado de Rosario, Rosario

RECRUITING

The Canberra Hospital, Garran

RECRUITING

Westmead Hospital, Westmead

ACTIVE_NOT_RECRUITING

Cairns Hospital, Cairns

RECRUITING

Eastern Health - Box Hill Hospital, Box Hill

RECRUITING

Fiona Stanley Hospital, Perth

RECRUITING

Royal Adelaide Hospital, Adelaide

RECRUITING

The Alfred Hospital, Melbourne

RECRUITING

Princess Alexandra Hospital, Woolloongabba

RECRUITING

Medizinische Universitaet Innsbruck, Innsbruck

RECRUITING

Universitaesklinikum St. Poelten, Sankt Pölten

RECRUITING

AZ Sint-Jan Brugge, Bruges

RECRUITING

Universite Libre de Bruxelles (ULB) - Hopital Erasme, Brussels

RECRUITING

Antwerp University Hospital, Edegem

RECRUITING

UZ Leuven, Leuven

RECRUITING

Centre Hospitalier Regional de la Citadelle, Liège

RECRUITING

Centro de Pesquisa NUPEC - Instituto Orizonti em Belo Horizonte, Belo Horizonte

RECRUITING

Complexo Hospitalar de Niterói (CHN-DASA), Niterói

RECRUITING

CAPED - Centro Avancado de Pesquisa, Ribeirão Preto

RECRUITING

HCFMRP - Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto, Ribeirão Preto

RECRUITING

Cardiopulmonar da Bahia S. A. (Hospital Cardio Pulmonar), Salvador

RECRUITING

Hospital Israelita Albert Einstein, São Paulo

RECRUITING

Instituto Dante Pazzanese de Cardiologia, São Paulo

RECRUITING

Instituto do Coracao (InCor) do Hospital das Clinicas da FMUSP, São Paulo

RECRUITING

PSEG Centro de Pesquisa Clinica S.A., São Paulo

RECRUITING

Alberta Health Services - University of Calgary, Calgary

RECRUITING

Vancouver Coastal Health Research Institute, Vancouver

RECRUITING

University Health Network - Toronto General Hospital, Toronto

RECRUITING

McGill University Health Centre, Montreal

RECRUITING

Fakultni nemocnice u sv. Anny v Brne, Brno

RECRUITING

Aarhus University Hospital, Aarhus

RECRUITING

Rigshospitalet, Copenhagen

RECRUITING

AP-HP Hopital Henri Mondor, Créteil

RECRUITING

AP-HM - Hopital de la Timone, Marseille

RECRUITING

AP-HP Hopital Bichat - Claude Bernard, Paris

RECRUITING

CHU Rennes - Hopital Pontchaillou, Rennes

RECRUITING

CHU de Toulouse - Hopital Rangueil, Toulouse

RECRUITING

Charite Universitaetsmedizin Berlin, Berlin

RECRUITING

Universitaetsklinikum Essen, Essen

RECRUITING

Universitaetsklinikum Heidelberg, Heidelberg

RECRUITING

Universitaetsklinikum Wuerzburg, Würzburg

RECRUITING

Semmelweis Egyetem Belgyogyaszati es Hematologiai Klinika, Budapest

RECRUITING

Rambam Health Care Campus, Haifa

RECRUITING

Hadassah University Hospital, Ein Karem, Jerusalem

RECRUITING

Sheba Medical Center, Tel Litwinsky

RECRUITING

IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant'Orsola, Bologna

RECRUITING

Azienda Ospedaliero-Universitaria di Ferrara-Arcispedale Sant'Anna, Cona

RECRUITING

Azienda Ospedaliero-Universitaria Careggi, Florence

RECRUITING

Ospedale Policlinico San Martino IRCCS, Genova

RECRUITING

Fondazione IRCCS Policlinico San Matteo, Pavia

RECRUITING

Fondazione Toscana Gabriele Monasterio per la Ricerca Medica, Pisa

RECRUITING

Azienda sanitaria universitaria Giuliano Isontina (ASU GI) - Ospedale di Cattinara, Trieste

RECRUITING

Kumamoto University Hospital, Kumamoto

RECRUITING

National Cerebral and Cardiovascular Center, Osaka

RECRUITING

The University of Tokyo Hospital, Tokyo

RECRUITING

Toyama University Hospital, Toyama

RECRUITING

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City

RECRUITING

University Medical Center, Groningen

RECRUITING

Erasmus MC, Rotterdam

RECRUITING

Universitair Medisch Centrum Utrecht, Utrecht

RECRUITING

New Zealand Clinical Research, Auckland

RECRUITING

New Zealand Clinical Research, Christchurch

RECRUITING

Oslo University Hospital - Rikshospitalet, Oslo

RECRUITING

Centro Hospitalar Universitario de Lisboa Norte, Lisbon

RECRUITING

Centro Hospitalar Universitario do Porto, Porto

RECRUITING

National Heart Centre, Singapore

RECRUITING

National University Hospital, Singapore

RECRUITING

Chonnam National University Hospital, Gwangju

RECRUITING

Samsung Medical Center, Seoul

RECRUITING

Seoul National University Hospital, Seoul

RECRUITING

Severance Hospital, Yonsei University Health System, Seoul

RECRUITING

Hospital Universitario de A Coruna, A Coruña

RECRUITING

Hospital Universitari de Bellvitge, Barcelona

RECRUITING

Hospital Universitario Vall d'Hebron, Barcelona

RECRUITING

Hospital Universitario Puerta de Hierro, Majadahonda

RECRUITING

Hospital Universitario Virgen de la Victoria, Málaga

RECRUITING

Hospital Universitario Son Llatzer, Palma de Mallorca

RECRUITING

Karolinska University Hospital, Stockholm

RECRUITING

University Hospital of Umea, Umeå

RECRUITING

Far Eastern Memorial Hospital, New Taipei City

RECRUITING

National Taiwan University Hospital, Taipei

RECRUITING

Taipai Veterans General Hospital, Taipei

ACTIVE_NOT_RECRUITING

Synexus Midlands Clinical Research Centre, Birmingham

ACTIVE_NOT_RECRUITING

Synexus Wales Clinical Research Centre, Cardiff

ACTIVE_NOT_RECRUITING

Synexus Scotland Clinical Research Centre, Glasgow

ACTIVE_NOT_RECRUITING

Synexus Hexham Clinical Research Centre, Hexham

ACTIVE_NOT_RECRUITING

Synexus Merseyside Clinical Research Centre, Liverpool

RECRUITING

Richmond Pharmacology, London

ACTIVE_NOT_RECRUITING

Synexus Manchester Clinical Research Centre, Manchester

Sponsors
All Listed Sponsors
collaborator

Regeneron Pharmaceuticals

INDUSTRY

lead

Intellia Therapeutics

INDUSTRY

NCT06128629 - MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM) | Biotech Hunter | Biotech Hunter