Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

PHASE2RecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

May 7, 2024

Primary Completion Date

February 20, 2027

Study Completion Date

February 20, 2027

Conditions
Malignant Female Reproductive System NeoplasmMalignant Solid NeoplasmRecurrent Malignant Female Reproductive System NeoplasmRecurrent Malignant Solid Neoplasm
Interventions
PROCEDURE

Biopsy Procedure

Undergo tumor biopsy

PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

PROCEDURE

Computed Tomography

Undergo CT scan

PROCEDURE

Echocardiography Test

Undergo ECHO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

DRUG

Neratinib Maleate

Given PO

DRUG

Palbociclib

Given PO

Trial Locations (157)

13210

RECRUITING

State University of New York Upstate Medical University, Syracuse

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

15146

RECRUITING

UPMC Hillman Cancer Center - Monroeville, Monroeville

15213

RECRUITING

UPMC-Magee Womens Hospital, Pittsburgh

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

15237

RECRUITING

UPMC-Passavant Hospital, Pittsburgh

15601

RECRUITING

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

16505

RECRUITING

UPMC Hillman Cancer Center Erie, Erie

16601

RECRUITING

UPMC Altoona, Altoona

17050

RECRUITING

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg

19090

RECRUITING

Asplundh Cancer Pavilion, Willow Grove

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

20892

RECRUITING

National Institutes of Health Clinical Center, Bethesda

21201

RECRUITING

University of Maryland/Greenebaum Cancer Center, Baltimore

21502

RECRUITING

UPMC Western Maryland, Cumberland

22031

RECRUITING

Inova Schar Cancer Institute, Fairfax

22042

RECRUITING

Inova Fairfax Hospital, Falls Church

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

24201

RECRUITING

Ballad Health Cancer Care - Bristol, Bristol

26506

RECRUITING

West Virginia University Healthcare, Morgantown

27534

RECRUITING

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

27607

RECRUITING

Duke Women's Cancer Care Raleigh, Raleigh

27710

RECRUITING

Duke University Medical Center, Durham

28328

RECRUITING

Southeastern Medical Oncology Center-Clinton, Clinton

28546

RECRUITING

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

33065

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Springs, Coral Springs

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

35233

RECRUITING

University of Alabama at Birmingham Cancer Center, Birmingham

36688

RECRUITING

University of South Alabama Mitchell Cancer Institute, Mobile

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

37604

RECRUITING

Regional Cancer Center at Johnson City Medical Center, Johnson City

37620

RECRUITING

Bristol Regional Medical Center, Bristol

37660

RECRUITING

Ballad Health Cancer Care - Kingsport, Kingsport

RECRUITING

Wellmont Holston Valley Hospital and Medical Center, Kingsport

40509

RECRUITING

Saint Joseph Hospital East, Lexington

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

45331

RECRUITING

Miami Valley Cancer Care and Infusion, Greenville

45373

RECRUITING

Upper Valley Medical Center, Troy

45409

RECRUITING

Miami Valley Hospital, Dayton

RECRUITING

Premier Blood and Cancer Center, Dayton

45415

SUSPENDED

Dayton Physician LLC - Englewood, Dayton

RECRUITING

Miami Valley Hospital North, Dayton

45429

SUSPENDED

Kettering Medical Center, Kettering

45459

RECRUITING

Miami Valley Hospital South, Centerville

46360

SUSPENDED

Woodland Cancer Care Center, Michigan City

48073

RECRUITING

Corewell Health William Beaumont University Hospital, Royal Oak

48085

RECRUITING

Corewell Health Beaumont Troy Hospital, Troy

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

48118

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48124

RECRUITING

Corewell Health Dearborn Hospital, Dearborn

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48336

RECRUITING

Corewell Health Farmington Hills Hospital, Farmington Hills

48341

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48503

RECRUITING

Cancer Hematology Centers - Flint, Flint

SUSPENDED

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

RECRUITING

Hurley Medical Center, Flint

48912

RECRUITING

University of Michigan Health - Sparrow Lansing, Lansing

49829

RECRUITING

OSF Saint Francis Hospital and Medical Group, Escanaba

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50263

RECRUITING

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50309

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

RECRUITING

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

53081

RECRUITING

Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan

54154

RECRUITING

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54301

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

RECRUITING

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54449

RECRUITING

Marshfield Medical Center-Marshfield, Marshfield

54476

RECRUITING

Marshfield Medical Center - Weston, Weston

54482

RECRUITING

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

RECRUITING

Marshfield Medical Center - Minocqua, Minocqua

54601

RECRUITING

Gundersen Lutheran Medical Center, La Crosse

54701

RECRUITING

Marshfield Medical Center-EC Cancer Center, Eau Claire

54806

RECRUITING

Duluth Clinic Ashland, Ashland

54868

RECRUITING

Marshfield Medical Center-Rice Lake, Rice Lake

55072

RECRUITING

Essentia Health Sandstone, Sandstone

55109

RECRUITING

Saint John's Hospital - Healtheast, Maplewood

55746

RECRUITING

Essentia Health Hibbing Clinic, Hibbing

55792

RECRUITING

Essentia Health Virginia Clinic, Virginia

55805

RECRUITING

Essentia Health Cancer Center, Duluth

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

56601

RECRUITING

Sanford Joe Lueken Cancer Center, Bemidji

56636

RECRUITING

Essentia Health - Deer River Clinic, Deer River

57104

RECRUITING

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

58501

RECRUITING

Sanford Bismarck Medical Center, Bismarck

59101

RECRUITING

Billings Clinic Cancer Center, Billings

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

59711

RECRUITING

Community Hospital of Anaconda, Anaconda

59715

RECRUITING

Bozeman Health Deaconess Hospital, Bozeman

59804

RECRUITING

Community Medical Center, Missoula

59901

RECRUITING

Logan Health Medical Center, Kalispell

60026

RECRUITING

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

RECRUITING

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60201

RECRUITING

NorthShore University HealthSystem-Evanston Hospital, Evanston

60612

SUSPENDED

John H Stroger Jr Hospital of Cook County, Chicago

RECRUITING

University of Illinois, Chicago

61114

RECRUITING

Mercyhealth Cancer Institute - Rockford, Rockford

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

62918

RECRUITING

SIH Cancer Institute, Carterville

63703

RECRUITING

Saint Francis Medical Center, Cape Girardeau

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

77030

RECRUITING

M D Anderson Cancer Center, Houston

83605

RECRUITING

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83619

RECRUITING

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

RECRUITING

Saint Luke's Cancer Institute - Meridian, Meridian

83687

RECRUITING

Saint Alphonsus Cancer Care Center-Nampa, Nampa

RECRUITING

Saint Luke's Cancer Institute - Nampa, Nampa

83706

RECRUITING

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

RECRUITING

Saint Luke's Cancer Institute - Boise, Boise

83814

RECRUITING

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

RECRUITING

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

RECRUITING

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

89052

RECRUITING

OptumCare Cancer Care at Seven Hills, Henderson

89102

RECRUITING

OptumCare Cancer Care at Charleston, Las Vegas

89148

RECRUITING

OptumCare Cancer Care at Fort Apache, Las Vegas

90025

RECRUITING

The Angeles Clinic and Research Institute - West Los Angeles Office, Los Angeles

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

92024

RECRUITING

UC San Diego Health System - Encinitas, Encinitas

92093

RECRUITING

UC San Diego Moores Cancer Center, La Jolla

92103

RECRUITING

UC San Diego Medical Center - Hillcrest, San Diego

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence Saint Vincent Medical Center, Portland

97914

RECRUITING

Saint Alphonsus Cancer Care Center-Ontario, Ontario

98122

RECRUITING

Swedish Medical Center-First Hill, Seattle

04330

RECRUITING

Harold Alfond Center for Cancer Care, Augusta

04412

RECRUITING

Lafayette Family Cancer Center-EMMC, Brewer

04074

RECRUITING

MaineHealth Maine Medical Center- Scarborough, Scarborough

07302

RECRUITING

Jersey City Medical Center, Jersey City

08701

RECRUITING

Monmouth Medical Center Southern Campus, Lakewood

07740

RECRUITING

Monmouth Medical Center, Long Branch

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

08755

RECRUITING

Community Medical Center, Toms River

45005-1066

RECRUITING

Atrium Medical Center-Middletown Regional Hospital, Franklin

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

54235-1495

RECRUITING

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH