222
Participants
Start Date
May 30, 2025
Primary Completion Date
December 1, 2030
Study Completion Date
December 1, 2030
Biospecimen Collection
Undergo blood and CSF sample collection
Blinatumomab
Receive IV
Bone Marrow Biopsy
Undergo bone marrow biopsy
Calaspargase Pegol
Receive IV
Cyclophosphamide
Receive IV
Cytarabine
Receive IV or subcutaneously
Dasatinib
Receive PO
Daunorubicin
Receive IV
Doxorubicin
Receive IV
Echocardiography Test
Undergo ECHO
Imatinib
Given PO
Leucovorin
Receive PO or IV
Mercaptopurine
Receive PO
Methotrexate
Receive IT or IV or PO
Multigated Acquisition Scan
Undergo MUGA
Pegaspargase
Receive IV or intramuscularly
Prednisolone
Receive PO
Prednisone
Receive PO
Radiation Therapy
Undergo radiation therapy
Thioguanine
Receive PO
Vincristine
Receive IV
RECRUITING
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
RECRUITING
New York Medical College, Valhalla
RECRUITING
Stony Brook University Medical Center, Stony Brook
RECRUITING
Albany Medical Center, Albany
RECRUITING
State University of New York Upstate Medical University, Syracuse
RECRUITING
Roswell Park Cancer Institute, Buffalo
RECRUITING
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
RECRUITING
Children's Hospital of Philadelphia, Philadelphia
RECRUITING
Saint Christopher's Hospital for Children, Philadelphia
RECRUITING
Alfred I duPont Hospital for Children, Wilmington
RECRUITING
MedStar Georgetown University Hospital, Washington D.C.
RECRUITING
Children's National Medical Center, Washington D.C.
RECRUITING
Sinai Hospital of Baltimore, Baltimore
RECRUITING
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
RECRUITING
Inova Fairfax Hospital, Falls Church
RECRUITING
University of Virginia Cancer Center, Charlottesville
RECRUITING
VCU Massey Comprehensive Cancer Center, Richmond
RECRUITING
Children's Hospital of The King's Daughters, Norfolk
RECRUITING
Mission Hospital, Asheville
RECRUITING
Prisma Health Richland Hospital, Columbia
RECRUITING
BI-LO Charities Children's Cancer Center, Greenville
RECRUITING
Augusta University Medical Center, Augusta
RECRUITING
Memorial Health University Medical Center, Savannah
RECRUITING
Nemours Children's Clinic-Jacksonville, Jacksonville
RECRUITING
University of Florida Health Science Center - Gainesville, Gainesville
RECRUITING
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
RECRUITING
Johns Hopkins All Children's Hospital, St. Petersburg
RECRUITING
Golisano Children's Hospital of Southwest Florida, Fort Myers
RECRUITING
Children's Hospital of Alabama, Birmingham
RECRUITING
The Children's Hospital at TriStar Centennial, Nashville
RECRUITING
University of Mississippi Medical Center, Jackson
RECRUITING
University of Kentucky/Markey Cancer Center, Lexington
RECRUITING
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
RECRUITING
Riley Hospital for Children, Indianapolis
RECRUITING
C S Mott Children's Hospital, Ann Arbor
RECRUITING
Children's Hospital of Michigan, Detroit
RECRUITING
Bronson Methodist Hospital, Kalamazoo
RECRUITING
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
RECRUITING
Children's Hospital of Wisconsin, Milwaukee
RECRUITING
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
RECRUITING
University of Minnesota/Masonic Cancer Center, Minneapolis
RECRUITING
Advocate Children's Hospital-Park Ridge, Park Ridge
RECRUITING
Advocate Children's Hospital-Oak Lawn, Oak Lawn
RECRUITING
Lurie Children's Hospital-Chicago, Chicago
RECRUITING
University of Chicago Comprehensive Cancer Center, Chicago
RECRUITING
Southern Illinois University School of Medicine, Springfield
RECRUITING
Children's Mercy Hospitals and Clinics, Kansas City
RECRUITING
Children's Hospital and Medical Center of Omaha, Omaha
RECRUITING
Ochsner Medical Center Jefferson, New Orleans
RECRUITING
Medical City Dallas Hospital, Dallas
RECRUITING
Cook Children's Medical Center, Fort Worth
RECRUITING
Children's Hospital of San Antonio, San Antonio
RECRUITING
Methodist Children's Hospital of South Texas, San Antonio
RECRUITING
University of Texas Health Science Center at San Antonio, San Antonio
RECRUITING
Driscoll Children's Hospital, Corpus Christi
RECRUITING
Dell Children's Medical Center of Central Texas, Austin
RECRUITING
Covenant Children's Hospital, Lubbock
RECRUITING
UMC Cancer Center / UMC Health System, Lubbock
RECRUITING
El Paso Children's Hospital, El Paso
RECRUITING
Children's Hospital Colorado, Aurora
RECRUITING
Saint Luke's Cancer Institute - Boise, Boise
RECRUITING
Primary Children's Hospital, Salt Lake City
RECRUITING
Loma Linda University Medical Center, Loma Linda
RECRUITING
Lucile Packard Children's Hospital Stanford University, Palo Alto
RECRUITING
Kaiser Permanente-Oakland, Oakland
RECRUITING
Kapiolani Medical Center for Women and Children, Honolulu
RECRUITING
Seattle Children's Hospital, Seattle
RECRUITING
Mary Bridge Children's Hospital and Health Center, Tacoma
RECRUITING
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
RECRUITING
Arkansas Children's Hospital, Little Rock
RECRUITING
Yale University, New Haven
RECRUITING
Maine Children's Cancer Program, Scarborough
RECRUITING
UMass Memorial Medical Center - University Campus, Worcester
RECRUITING
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
RECRUITING
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
RECRUITING
Saint Joseph's Regional Medical Center, Paterson
RECRUITING
University of Vermont and State Agricultural College, Burlington
RECRUITING
IWK Health Centre, Halifax
RECRUITING
Centre Hospitalier Universitaire Sainte-Justine, Montreal
RECRUITING
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke
RECRUITING
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec
RECRUITING
University Pediatric Hospital, San Juan
National Cancer Institute (NCI)
NIH