A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

PHASE3RecruitingINTERVENTIONAL
Enrollment

222

Participants

Timeline

Start Date

May 30, 2025

Primary Completion Date

December 1, 2030

Study Completion Date

December 1, 2030

Conditions
B Acute Lymphoblastic Leukemia
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood and CSF sample collection

BIOLOGICAL

Blinatumomab

Receive IV

PROCEDURE

Bone Marrow Biopsy

Undergo bone marrow biopsy

DRUG

Calaspargase Pegol

Receive IV

DRUG

Cyclophosphamide

Receive IV

DRUG

Cytarabine

Receive IV or subcutaneously

DRUG

Dasatinib

Receive PO

DRUG

Daunorubicin

Receive IV

DRUG

Doxorubicin

Receive IV

PROCEDURE

Echocardiography Test

Undergo ECHO

DRUG

Imatinib

Given PO

DRUG

Leucovorin

Receive PO or IV

DRUG

Mercaptopurine

Receive PO

DRUG

Methotrexate

Receive IT or IV or PO

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

DRUG

Pegaspargase

Receive IV or intramuscularly

DRUG

Prednisolone

Receive PO

DRUG

Prednisone

Receive PO

RADIATION

Radiation Therapy

Undergo radiation therapy

DRUG

Thioguanine

Receive PO

DRUG

Vincristine

Receive IV

Trial Locations (83)

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10595

RECRUITING

New York Medical College, Valhalla

11794

RECRUITING

Stony Brook University Medical Center, Stony Brook

12208

RECRUITING

Albany Medical Center, Albany

13210

RECRUITING

State University of New York Upstate Medical University, Syracuse

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

15224

RECRUITING

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

19134

RECRUITING

Saint Christopher's Hospital for Children, Philadelphia

19803

RECRUITING

Alfred I duPont Hospital for Children, Wilmington

20007

RECRUITING

MedStar Georgetown University Hospital, Washington D.C.

20010

RECRUITING

Children's National Medical Center, Washington D.C.

21215

RECRUITING

Sinai Hospital of Baltimore, Baltimore

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22042

RECRUITING

Inova Fairfax Hospital, Falls Church

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

23507

RECRUITING

Children's Hospital of The King's Daughters, Norfolk

28801

RECRUITING

Mission Hospital, Asheville

29203

RECRUITING

Prisma Health Richland Hospital, Columbia

29605

RECRUITING

BI-LO Charities Children's Cancer Center, Greenville

30912

RECRUITING

Augusta University Medical Center, Augusta

31404

RECRUITING

Memorial Health University Medical Center, Savannah

32207

RECRUITING

Nemours Children's Clinic-Jacksonville, Jacksonville

32610

RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

33021

RECRUITING

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33701

RECRUITING

Johns Hopkins All Children's Hospital, St. Petersburg

33908

RECRUITING

Golisano Children's Hospital of Southwest Florida, Fort Myers

35233

RECRUITING

Children's Hospital of Alabama, Birmingham

37203

RECRUITING

The Children's Hospital at TriStar Centennial, Nashville

39216

RECRUITING

University of Mississippi Medical Center, Jackson

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43606

RECRUITING

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo

45229

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

46202

RECRUITING

Riley Hospital for Children, Indianapolis

48109

RECRUITING

C S Mott Children's Hospital, Ann Arbor

48201

RECRUITING

Children's Hospital of Michigan, Detroit

49007

RECRUITING

Bronson Methodist Hospital, Kalamazoo

49503

RECRUITING

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids

53226

RECRUITING

Children's Hospital of Wisconsin, Milwaukee

54301

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

55455

RECRUITING

University of Minnesota/Masonic Cancer Center, Minneapolis

60068

RECRUITING

Advocate Children's Hospital-Park Ridge, Park Ridge

60453

RECRUITING

Advocate Children's Hospital-Oak Lawn, Oak Lawn

60611

RECRUITING

Lurie Children's Hospital-Chicago, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

64108

RECRUITING

Children's Mercy Hospitals and Clinics, Kansas City

68114

RECRUITING

Children's Hospital and Medical Center of Omaha, Omaha

70121

RECRUITING

Ochsner Medical Center Jefferson, New Orleans

75230

RECRUITING

Medical City Dallas Hospital, Dallas

76104

RECRUITING

Cook Children's Medical Center, Fort Worth

78207

RECRUITING

Children's Hospital of San Antonio, San Antonio

78229

RECRUITING

Methodist Children's Hospital of South Texas, San Antonio

RECRUITING

University of Texas Health Science Center at San Antonio, San Antonio

78411

RECRUITING

Driscoll Children's Hospital, Corpus Christi

78723

RECRUITING

Dell Children's Medical Center of Central Texas, Austin

79410

RECRUITING

Covenant Children's Hospital, Lubbock

79415

RECRUITING

UMC Cancer Center / UMC Health System, Lubbock

79905

RECRUITING

El Paso Children's Hospital, El Paso

80045

RECRUITING

Children's Hospital Colorado, Aurora

83712

RECRUITING

Saint Luke's Cancer Institute - Boise, Boise

84113

RECRUITING

Primary Children's Hospital, Salt Lake City

92354

RECRUITING

Loma Linda University Medical Center, Loma Linda

94304

RECRUITING

Lucile Packard Children's Hospital Stanford University, Palo Alto

94611

RECRUITING

Kaiser Permanente-Oakland, Oakland

96826

RECRUITING

Kapiolani Medical Center for Women and Children, Honolulu

98105

RECRUITING

Seattle Children's Hospital, Seattle

98405

RECRUITING

Mary Bridge Children's Hospital and Health Center, Tacoma

99204

RECRUITING

Providence Sacred Heart Medical Center and Children's Hospital, Spokane

72202-3591

RECRUITING

Arkansas Children's Hospital, Little Rock

06520

RECRUITING

Yale University, New Haven

04074

RECRUITING

Maine Children's Cancer Program, Scarborough

01655

RECRUITING

UMass Memorial Medical Center - University Campus, Worcester

03756

RECRUITING

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

08903

RECRUITING

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick

07503

RECRUITING

Saint Joseph's Regional Medical Center, Paterson

05405

RECRUITING

University of Vermont and State Agricultural College, Burlington

B3K 6R8

RECRUITING

IWK Health Centre, Halifax

H3T 1C5

RECRUITING

Centre Hospitalier Universitaire Sainte-Justine, Montreal

J1H 5N4

RECRUITING

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke

G1V 4G2

RECRUITING

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec

00926

RECRUITING

University Pediatric Hospital, San Juan

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH