Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty

PHASE2RecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

April 16, 2024

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2026

Conditions
Chronic PainKnee Pain ChronicPost Operative Pain
Interventions
DRUG

Vitamin C

Drug: Patients in the intervention group will receive 2g Vitamin C orally within 4 hours of the start of the surgery followed by 500 mg of Vitamin C to be taken orally twice a day from post-op day1 to day 56.

DRUG

Placebo

Drug: Patients in the placebo group will receive identical placebo capsules taken orally within 4 hours of the start of the surgery followed by placebo capsules taken orally twice a day from post-op day 1 to day 56.

Trial Locations (3)

M4Y 1H1

RECRUITING

Sunnybrook - Holland Centre, Toronto

M5G 1X5

RECRUITING

Mount Sinai Hospital, Toronto

M5T 2S8

RECRUITING

Toronto Western Hospital, Toronto

All Listed Sponsors
collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

collaborator

The Arthritis Society, Canada

OTHER

lead

University Health Network, Toronto

OTHER