Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

PHASE2RecruitingINTERVENTIONAL
Enrollment

208

Participants

Timeline

Start Date

November 7, 2023

Primary Completion Date

July 3, 2026

Study Completion Date

July 3, 2026

Conditions
Heart Failure
Interventions
DRUG

BMS-986435

Specified dose on specified days

OTHER

Placebo

Specified dose on specified days

Trial Locations (117)

0

NOT_YET_RECRUITING

Local Institution - 0098, Seongnam-si

1407

RECRUITING

Centro de Especialidades Médicas CEMEDIC, Buenos Aires

6351

NOT_YET_RECRUITING

Local Institution - 0114, Seoul

11215

NOT_YET_RECRUITING

Local Institution - 0105, Brooklyn

12211

RECRUITING

Capital Cardiology Associates, Albany

13100

NOT_YET_RECRUITING

Local Institution - 0116, Safed

14621

RECRUITING

Rochester General Hospital Center for Clinical Research, Rochester

19001

RECRUITING

Abington Memorial Hospital, Abington

20090

WITHDRAWN

Local Institution - 0020, Lublin

WITHDRAWN

Local Institution - 0049, Lublin

20097

RECRUITING

IRCCS Policlinico San Donato, San Donato Milanese

WITHDRAWN

Local Institution - 0050, San Donato Milanese

20162

WITHDRAWN

Local Institution - 0023, Milan

WITHDRAWN

Local Institution - 0033, Milan

22332

RECRUITING

Inha University Hospital, Junggu

24127

COMPLETED

Local Institution - 0009, Bergamo

28034

COMPLETED

Local Institution - 0026, Madrid

WITHDRAWN

Local Institution - 0034, Madrid

28222

COMPLETED

Local Institution - 0025, Majadahonda

WITHDRAWN

Local Institution - 0047, Majadahonda

29010

WITHDRAWN

Local Institution - 0042, Málaga

ACTIVE_NOT_RECRUITING

Local Institution - 0032, Málaga

30120

RECRUITING

Hospital Universitario Virgen de La Arrixaca, El Palmar

WITHDRAWN

Local Institution - 0039, El Palmar

35015

RECRUITING

Chungnam National University Hospital, Daejeon

35233

RECRUITING

University of Alabama at Birmingham, Birmingham

41014

RECRUITING

Hospital Nuestra Señora de Valme, Seville

WITHDRAWN

Local Institution - 0046, Seville

42601

RECRUITING

Keimyung University Dongsan Hospital, Daegu

45242

WITHDRAWN

Local Institution - 0058, Cincinnati

46010

COMPLETED

Local Institution - 0010, Valencia

49100

NOT_YET_RECRUITING

Local Institution - 0110, Petah Tikva

49241

RECRUITING

Pusan National University Hospital, Busan

51162

WITHDRAWN

Local Institution - 0024, Oświęcim

54100

WITHDRAWN

Local Institution - 0052, Massa

56124

COMPLETED

Local Institution - 0017, Pisa

61469

NOT_YET_RECRUITING

Local Institution - 0083, Gwangju

63136

WITHDRAWN

Local Institution - 0043, St Louis

71100

WITHDRAWN

Local Institution - 0027, Foggia

WITHDRAWN

Local Institution - 0038, Foggia

75390

RECRUITING

University of Texas Southwestern Medical Center, Dallas

76100

NOT_YET_RECRUITING

Local Institution - 0106, Rehovot

80131

COMPLETED

Local Institution - 0019, Napoli

84101

NOT_YET_RECRUITING

Local Institution - 0111, Beersheba

90000

NOT_YET_RECRUITING

Local Institution - 0109, Jerusalem

100730

RECRUITING

Peking Union Medical College Hospital - East Campus, Beijing

310009

RECRUITING

The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

410011

RECRUITING

The Second Xiangya Hospital of Central South University, Changsha

471003

RECRUITING

The First Affiliated Hospital of Henan Science and Technology University - Jinghua Campus, Luoyang

510120

RECRUITING

Guangdong Provincial People's Hospital, Guangzhou

3109601

NOT_YET_RECRUITING

Local Institution - 0108, Haifa

7033001

NOT_YET_RECRUITING

Local Institution - 0112, Be’er Ya‘aqov

9103102

NOT_YET_RECRUITING

Local Institution - 0113, Jerusalem

80228-1710

RECRUITING

Colorado Heart and Vascular - Lakewood, Lakewood

32204-4748

RECRUITING

Ascension St. Vincent's Riverside Hospital - PPDS, Jacksonville

33133-4223

ACTIVE_NOT_RECRUITING

Local Institution - 0003, Miami

33136-2107

NOT_YET_RECRUITING

Local Institution - 0099, Miami

30322-1013

WITHDRAWN

Local Institution - 0014, Atlanta

WITHDRAWN

Local Institution - 0048, Atlanta

60611-5969

RECRUITING

Bluhm Cardiovascular Institute of Northwestern, Chicago

60429-2196

RECRUITING

Chicago Medical Research, LLC - Hazel Crest, Hazel Crest

46260-1992

RECRUITING

Ascension Medical Group St. Vincent - Indianapolis Heart Care, Indianapolis

WITHDRAWN

Local Institution - 0045, Indianapolis

63136-6111

RECRUITING

St. Louis Heart and Vascular, St Louis

07601

NOT_YET_RECRUITING

Local Institution - 0117, Hackensack

10065-4805

RECRUITING

Weill Cornell Medicine, New York

14618-2668

RECRUITING

University of Rochester Medical Center - PPDS, Rochester

11422-1320

RECRUITING

Laurelton Heart Specialist PC - MyClinical - PPDS, Rosedale

27710-4000

NOT_YET_RECRUITING

Local Institution - 0095, Durham

73135-2607

WITHDRAWN

Local Institution - 0041, Oklahoma City

RECRUITING

South Oklahoma Heart Research, Oklahoma City

37388-8260

RECRUITING

Tennessee Center for Clinical Trials, Tullahoma

78756-4080

NOT_YET_RECRUITING

Local Institution - 0104, Austin

77025-5253

RECRUITING

Angiocardiac Care of Texas - PA - PPDS, Houston

WITHDRAWN

Local Institution - 0051, Houston

22042-1262

WITHDRAWN

Local Institution - 0066, Falls Church

B1650BNB

NOT_YET_RECRUITING

Local Institution - 0054, Ciudad del Libertador General San Martín

B2800DGH

WITHDRAWN

Local Institution - 0107, Zárate

NOT_YET_RECRUITING

Local Institution - 0115, Zárate

X5000AAX

NOT_YET_RECRUITING

Local Institution - 0090, Córdoba

X5003DCE

NOT_YET_RECRUITING

Local Institution - 0053, Córdoba

S2000DSR

NOT_YET_RECRUITING

Local Institution - 0073, Rosario

T4000JCU

NOT_YET_RECRUITING

Local Institution - 0061, San Miguel de Tucumán

C1179AAB

WITHDRAWN

Local Institution - 0068, Buenos Aires

C1431FWO

NOT_YET_RECRUITING

Local Institution - 0067, Buenos Aires

X5000AOQ

NOT_YET_RECRUITING

Local Institution - 0074, Córdoba

A4406BPF

NOT_YET_RECRUITING

Local Institution - 0069, Salta

S3000FWO

NOT_YET_RECRUITING

Local Institution - 0102, Santa Fe

L8L 2X2

RECRUITING

Hamilton General Hospital, Hamilton

M4P 1E4

RECRUITING

Medicus MFC Inc., Toronto

M5S 1B2

WITHDRAWN

Local Institution - 0030, Toronto

WITHDRAWN

Local Institution - 0040, Toronto

H1T 1C8

WITHDRAWN

Local Institution - 0011, Montreal

G9A 1Y1

WITHDRAWN

Local Institution - 0035, Trois-Rivières

672-8044

RECRUITING

Hyogo Prefectural Harima-Himeji General Medical Center, Himeji-Shi

920-8650

RECRUITING

National Hospital Organization Kanazawa Medical Center, Kanazawa

702-8055

RECRUITING

Okayama Rosai Hospital, Okayama

596-0042

RECRUITING

Kishiwada Tokushukai Hospital, Kishiwada

569-1045

RECRUITING

Takatsuki Red Cross Hospital, Takatsuki-Shi

92-213

RECRUITING

Clinical Trials UMED Sp. z o.o., Lódz

15-276

COMPLETED

Local Institution - 0031, Bialystok

WITHDRAWN

Local Institution - 0044, Bialystok

30-082

WITHDRAWN

Local Institution - 0006, Krakow

03722

NOT_YET_RECRUITING

Local Institution - 0085, Seoul

03080

NOT_YET_RECRUITING

Local Institution - 0081, Seoul

06591

RECRUITING

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

08907

COMPLETED

Local Institution - 0012, L'Hospitalet de Llobregat

HA1 3UJ

RECRUITING

Northwick Park Hospital, Harrow

NE29 8NH

RECRUITING

North Tyneside General Hospital, North Shields

LS1 3EX

NOT_YET_RECRUITING

Local Institution - 0072, Leeds

S5 7AU

WITHDRAWN

Local Institution - 0057, Sheffield

BS2 8HW

RECRUITING

Bristol Royal Infirmary, Bristol

DD1 9SY

NOT_YET_RECRUITING

Local Institution - 0097, Dundee

SE1 7EH

NOT_YET_RECRUITING

Local Institution - 0075, London

OX3 9DU

RECRUITING

John Radcliffe Hospital, Oxford

TS19 8PE

NOT_YET_RECRUITING

Local Institution - 0065, Stockton-on-Tees

WV10 0QP

RECRUITING

New Cross Hospital, Wolverhampton

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY