Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib

PHASE2RecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

February 16, 2024

Primary Completion Date

May 31, 2027

Study Completion Date

January 31, 2032

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG

Amivantamab IV

Amivantamab will be administered.

DRUG

Amivantamab SC

Amivantamab will be administered as SC injection.

DRUG

Lazertinib

Lazertinib tablet will be administered orally.

DRUG

Doxycycline

Doxycycline tablet will be administered orally.

DRUG

Minocycline

Minocycline capsule will be administered orally.

DRUG

Clindamycin

Clindamycin lotion will be used as topical application on the scalp.

DRUG

Chlorhexidine

Chlorhexidine solution will be used as topical application on hands and feet.

OTHER

Noncomedogenic skin moisturizer

Noncomedogenic skin moisturizer will be used as topical application.

OTHER

Ruxolitinib

Ruxolitinib will be used to the affected skin area.

OTHER

Tacrolimus

Tacrolimus will be used as topical application to the affected skin area.

DRUG

Zinc gluconate

Zinc gluconate tablet will be administered.

DRUG

Propranolol

Propranolol tablet will be administered.

DRUG

Timolol

Timolol will be used to the affected skin area.

DRUG

Clobetasol

Clobetasol shampoo will be used on the scalp.

Trial Locations (93)

100

RECRUITING

National Taiwan University Hospital, Taipei

333

RECRUITING

Linkou Chang Gung Memorial Hospital, Taoyuan

833

RECRUITING

Chang Gung Memorial Hospital, Kaohsiung City

1060

RECRUITING

Adana City Hospital, Adana

6800

RECRUITING

Ankara Bilkent City Hospital, Ankara

10450

RECRUITING

Hospital Pulau Pinang, George Town

11590

RECRUITING

Clinical Research Alliance Inc, Westbury

13915

RECRUITING

Hopital Nord, Marseille

15006

RECRUITING

Hosp Univ A Coruna, A Coruña

22031

RECRUITING

Virginia Cancer Specialists, Fairfax

23007

RECRUITING

Hosp. Univ. de Jaen, Jaén

24105

RECRUITING

Universitaetsklinikum Schleswig Holstein Campus Kiel, Kiel

25100

RECRUITING

Hospital Tengku Ampuan Afzan, Kuantan

27003

RECRUITING

Hosp. Univ. Lucus Augusti, Lugo

27893

RECRUITING

Regional Medical Oncology Center, Wilson

28007

RECRUITING

Hosp. Gral. Univ. Gregorio Maranon, Madrid

28644

RECRUITING

Chungbuk National University Hospital, Cheongju-si

29010

RECRUITING

Hosp Regional Univ de Malaga, Málaga

30059

RECRUITING

National Taiwan University Hospital Hsin Chu Branch, Taoyuan District

30607

RECRUITING

University Cancer & Blood Center, Athens

34125

RECRUITING

Klinikum Kassel GmbH, Kassel

34147

RECRUITING

Bakirkoy Training and Research Hospital, Istanbul

34295

RECRUITING

I A U VM Medical Park Florya Hastanesi, Istanbul

35100

RECRUITING

Ege University Medical Faculty, Izmir

35392

RECRUITING

Universitaetsklinikum Giessen und Marburg GmbH, Giessen

40705

RECRUITING

Taichung Veterans General Hospital, Taichung

41014

RECRUITING

Hosp. Ntra. Sra. de Valme, Seville

44106

RECRUITING

University Hospitals Cleveland Medical Center, Cleveland

45136

RECRUITING

Kliniken Essen-Mitte, Essen

52074

RECRUITING

Universitaetsklinikum der RWTH Aachen, Aachen

54669

RECRUITING

Gundersen Health System, West Salem

55420

RECRUITING

Ondokuz Mayis University, Samsun

59100

RECRUITING

University Malaya Medical Centre, Kuala Lumpur

60521

RECRUITING

Hope and Healing Care, Hinsdale

65807

RECRUITING

Oncology Hematology Associates, Springfield

69126

RECRUITING

Thoraxklinik am Universitatsklinikum Heidelberg, Heidelberg

75005

RECRUITING

Institut Curie, Paris

85224

RECRUITING

Ironwood Cancer and Research Center, Chandler

89502

RECRUITING

Renown Health Medical Oncology, Reno

90033

RECRUITING

Keck Hospital of USC, Los Angeles

90720

RECRUITING

Cancer and Blood Specialty Clinic, Los Alamitos

90813

RECRUITING

City of Hope Long Beach Elm, Long Beach

91010

RECRUITING

City of Hope, Duarte

91030

RECRUITING

City of Hope South Pasadena, South Pasadena

91204

RECRUITING

Los Angeles Cancer Network, Glendale

92618

RECRUITING

City of Hope Orange County Lennar Foundation Cancer Center, Irvine

92648

RECRUITING

City of Hope Seacliff, Huntington Beach

92663

RECRUITING

USC Norris Oncology Hematology Newport Beach, Newport Beach

92835

RECRUITING

Providence Fullerton, Fullerton

93586

RECRUITING

Hospital Umum Sarawak, Kuching

94115

RECRUITING

Kaiser Permanente San Francisco Medical Center, San Francisco

94589

RECRUITING

Kaiser Permanente Northern California, Vallejo

94596

RECRUITING

Kaiser Permanente Walnut Creek Medical Center, Walnut Creek

94611

RECRUITING

Kaiser Permanente Oakland Medical Center, Oakland

95051

RECRUITING

Kaiser Permanente Santa Clara Medical Center, Santa Clara

95661

RECRUITING

Kaiser Permanente Roseville Medical Center, Roseville

98055

COMPLETED

Valley Medical Center, Renton

150040

RECRUITING

Harbin medical university cancer hospital, Harbin

200032

RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

210000

ACTIVE_NOT_RECRUITING

Zhongda Hospital Southeast University, Nanjing

213004

RECRUITING

Changzhou No 2 Peoples Hospital, Changzhou

310003

COMPLETED

The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou

450008

RECRUITING

Henan Cancer Hospital, Zhengzhou

510080

ACTIVE_NOT_RECRUITING

The First Affiliated Hospital Sun Yat sen University, Guangzhou

516001

RECRUITING

Huizhou Municipal Central Hospital, Huizhou

610041

ACTIVE_NOT_RECRUITING

West China Hospital, Chengdoucun

RECRUITING

Sichuan Cancer Hospital, Chengdu

710061

RECRUITING

The First Affiliated Hospital of Xian Jiaotong University, Xi'an

08822

COMPLETED

Hunterdon Hematology Oncology, Flemington

C1199

RECRUITING

Hospital Italiano de Buenos Aires, Buenos Aires

C1122

RECRUITING

IADT Instituto Argentino de Diagnostico y Tratamiento, CABA

C1017

RECRUITING

Centro Medico Austral, Capital Federal

B1900AXI

COMPLETED

Hospital Italiano de La Plata, La Plata

B7602

RECRUITING

Hospital Privado de la Comunidad, Mar del Plata

66.073-005

RECRUITING

CTO Centro De Tratamento Oncologico LTDA, Belém

30150-221

RECRUITING

Santa Casa de Misericordia de Belo Horizonte, Belo Horizonte

81520-060

RECRUITING

Liga Paranaense de Combate ao Cancer, Curitiba

17.210-080

RECRUITING

Fundacao Doutor Amaral Carvalho, Jaú

91350 200

RECRUITING

Hospital Nossa Senhora da Conceicao S A, Porto Alegre

40170 070

RECRUITING

Nucleo de Oncologia da Bahia Oncoclinicas, Salvador

96835-100

RECRUITING

Hospital Ana Nery Santa Cruz do Sul, Santa Cruz do Sul

01246 000

RECRUITING

Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo, São Paulo

01509 900

RECRUITING

Fundacao Antonio Prudente A C Camargo Cancer Center, São Paulo

12030-200

RECRUITING

Servicos de Tratamento ao Cancer de Taubate LTDA - Instituto do Cancer Brasil Unidade Taubate, Taubaté

29043-260

RECRUITING

Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia, Vitória

06001

RECRUITING

Hopital PASTEUR, Nice

405-760

RECRUITING

Gachon University Gil Hospital, Incheon

03722

RECRUITING

Severance Hospital Yonsei University Health System, Seoul

03010

RECRUITING

Hosp. Gral. Univ. de Alicante, Alicante

08028

RECRUITING

Hosp. Univ. Quiron Dexeus, Barcelona

08035

RECRUITING

Hosp Univ Vall D Hebron, Barcelona

06010

RECRUITING

Gulhane Training and Research Hospital, Ankara

06560

RECRUITING

Gazi University Hospital, Ankara

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY