Study to Assess the Efficacy & Safety of KHK4951 in Patients With Diabetic Macular Edema

PHASE2RecruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

January 9, 2024

Primary Completion Date

August 31, 2026

Study Completion Date

September 30, 2026

Conditions
Diabetic Macular Edema (DME)
Interventions
DRUG

KHK4951

KHK4951 eye drop for 36 weeks until end of the trial

DRUG

Aflibercept Injection

Intravitreal injection (IVT) of aflibercept will be given as specified in the protocol

Trial Locations (87)

2000

RECRUITING

Sydney Eye Hospital, Sydney

RECRUITING

Sydney Retina Clinic & Day Surgery, Sydney

2135

RECRUITING

Strathfield Retina Clinic, Strathfield

2170

NOT_YET_RECRUITING

South West Retina, Liverpool

2447

RECRUITING

Kyung Hee University Hospital, Seoul

3002

RECRUITING

Centre for Eye Research Australia, East Melbourne

5000

RECRUITING

Adelaide Eye and Retina Centre, Adelaide

6591

NOT_YET_RECRUITING

The Catholic Univ of KOR, SSMH, Seoul

7008

NOT_YET_RECRUITING

Hobart Eye Surgeons, Hobart

11572

NOT_YET_RECRUITING

Ophthalmic Consultants of Long Island, Oceanside

13088

RECRUITING

Retina Vitreous Surgeons of Central NY, PC, Liverpool

13496

RECRUITING

CHA Bundang Medical Center, CHA University, Seongnam-si

13620

RECRUITING

Seoul National University Bundang Hospital, Seongam

18017

RECRUITING

Wills Eye Health System, Bethlehem

18704

RECRUITING

Eye Care Specialists, Kingston

21565

RECRUITING

Gachon University Gil Medical Center, Incheon

21740

RECRUITING

Mid Atlantic Retina Specialists - Hagerstown, Hagerstown

22031

RECRUITING

Retina Group of Washington, Fairfax

29414

RECRUITING

Retina Consultants of Charleston - (RCA Network Site), Charleston

29456

RECRUITING

Charleston Neuroscience Institute (RCA Network Site), Ladson

32308

RECRUITING

Southern Vitreoretinal Associates, Tallahassee

32901

RECRUITING

Florida Eye Associates, Melbourne

33324

NOT_YET_RECRUITING

Ft. Lauderdale Eye Institute, Plantation

33711

RECRUITING

Retina Vitreous Associates of Florida - Saint Petersburg, St. Petersburg

33761

RECRUITING

Blue Ocean Clinical Research West, Clearwater

33782

RECRUITING

Eye Associates of Pinellas, Pinellas Park

33880

RECRUITING

Center for Retina and Macular Disease - Ophthalmology, Winter Haven

38138

RECRUITING

Charles Retina Institute, Germantown

42415

RECRUITING

Yeungnam University Hospital, Daegu

42601

RECRUITING

Keimyung University Dongsan Hospital, Daegu

49241

RECRUITING

Pusan National University Hospital, Busan

57701

RECRUITING

Black Hills Regional Eye Institute - Ophthalmology, Rapid City

73013

RECRUITING

Retina Vitreous Center in Edmond Oklahoma, Edmond

76087

RECRUITING

Strategic Clinical Research Group, LLC, Willow Park

76104

RECRUITING

Texas Retina Associates, Fort Worth

77384

RECRUITING

Retina Consultants of Texas (RCA Network Site), The Woodlands

77401

NOT_YET_RECRUITING

Retina Consultants of Texas, Bellaire

78240

RECRUITING

Retinal Consultants of Texas- San Antonio (RCA Network site), San Antonio

78705

RECRUITING

Austin Retina Associates - Ophthalmology/Retina (RCA Network site), Austin

78750

RECRUITING

Austin Clinical Research, LLC, Austin

79606

RECRUITING

Retina Research Institute of Texas, Abilene

80909

NOT_YET_RECRUITING

Retina Consultants of Southern CO, Colorado Springs

85206

RECRUITING

Barnet Dulaney Perkins Eye Center - Phoenix, Mesa

85710

NOT_YET_RECRUITING

Retina Associates Southwest, P.C., Tucson

87109

RECRUITING

Vision Research Center Eye Associates of New Mexico, Albuquerque

89502

RECRUITING

Sierra Eye Associates, Reno

90211

RECRUITING

Retina Vitreous Associates Medical Group, Beverly Hills

91006

RECRUITING

Win Retina, Arcadia

91107

RECRUITING

California Eye Specialists Medical Group Inc, Pasadena

91436

RECRUITING

The Retina Partners, Encino

92374

RECRUITING

Retina Consultants of Southern California, Redlands

92647

RECRUITING

Salehi Retina Institute, Inc, Huntington Beach

97225

RECRUITING

EyeHealth Northwest, Portland

07003

RECRUITING

Envision Ocular, LLC, Bloomfield

05401

NOT_YET_RECRUITING

University of Vermont Fletcher Allen Health Care, Burlington

02640

RECRUITING

Eye Clinic Albury Wodonga, Albury

02150

RECRUITING

Marsden Eye Specialists, Parramatta

480-1195

RECRUITING

Aichi Medical University Hospital - Ophthalmology, Nagakute

462-0825

RECRUITING

MIYAKE Eye Hospital, Nagoya

285-8741

RECRUITING

Toho University Medical Center Sakura Hospital, Sakura

830-0011

RECRUITING

Kurume University Hospital, Kurume

963-8563

RECRUITING

Minamitohoku Eye Clinic, Kōriyama

060-0031

NOT_YET_RECRUITING

Caress Sapporo Tokeidai Memorial Hospital, Sapporo

650-0017

RECRUITING

Kobe University Hospital - Ophthalmology, Kobe

310-0845

RECRUITING

Kozawa Eye Hospital and Diabetes Center, Mito

761-0793

RECRUITING

Kagawa University Hospital, Kita-gun

390-8621

NOT_YET_RECRUITING

Shinshu University Hospital - Ophthalmology, Matsumoto

634-8522

NOT_YET_RECRUITING

Nara Medical University Hospital - Ophthalmology, Kashihara

660-0892

NOT_YET_RECRUITING

Kansai Medical University Medical Center, Hirakata

577-8502

RECRUITING

Kindai University Hospital, Sayama

410-1102

RECRUITING

Muramatsu Clinic Muramatsu Eye Clinic - Ophthalmology, Susono

329-0498

NOT_YET_RECRUITING

Jichi Medical University Hospital, Shimotsuke

Unknown

RECRUITING

Nihon University Hospital, Chiyoda City

193-0998

RECRUITING

Tokyo Medical University Hachioji Medical Center, Hachiōji

152-8902

NOT_YET_RECRUITING

Tokyo Medical Center, Meguro City

160-8582

NOT_YET_RECRUITING

Keio University Hospital - Ophthalmology, Shinjuku

812-0011

RECRUITING

Hayashi Eye Hospital - Ophthalmology, Fukuoka

960-1295

RECRUITING

Fukushima Medical University Hospital - Ophthalmology, Fukushima

607-8062

RECRUITING

Rakuwakai Otowa Hospital, Kyoto

330-8553

RECRUITING

Saitama Red Cross Hospital, Saitama

545-0051

RECRUITING

Osaka Metropolitan University Hospital, Osaka

02841

NOT_YET_RECRUITING

Korea University Anam Hospital, Seoul

03080

RECRUITING

Seoul National University Hospital, Seoul

03722

RECRUITING

Severance Hospital, Yonsei University Health System, Seoul

05505

NOT_YET_RECRUITING

Asan Medical Center, Seoul

06351

NOT_YET_RECRUITING

Samsung Medical Center, Seoul

07301

RECRUITING

Kim Eye hospital, Seoul

All Listed Sponsors
lead

Kyowa Kirin Co., Ltd.

INDUSTRY