Individualized Positive End-Expiratory Pressure (PEEP) on Oxygenation, Hemodynamics, and Early Postoperative Atelectasis in Laparoscopic Bariatric Surgery

NARecruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

November 5, 2023

Primary Completion Date

April 1, 2024

Study Completion Date

April 1, 2024

Conditions
Positive End-expiratory PressureHemodynamic VariablePostoperative AtelectasisLaparoscopic Bariatric Surgery
Interventions
OTHER

Positive end-expiratory pressure 5 (PEEP 5)

Fixed positive end-expiratory pressure of 5 cmH2O will be maintained throughout the duration of surgery

OTHER

Individualized positive end-expiratory pressure (PEEPIND)

Patients will receive the individualized positive end-expiratory pressure. Titration process will be started after establishment of pneumoperitoneum: setting the initial PEEP to 5 cmH2O, then increasing positive end-expiratory pressure (PEEP)according to the gradient of 2 cmH2O every 3 min, calculating static compliance (Cstat) according to the formula: \[Cstat = VT/Pplat - PEEP\] (Pplat = plateau pressure), then gradually increasing positive end-expiratory pressure , until the calculated Cstat shows a downward trend, set its previous PEEP (corresponding to PEEP for high Cstat) as the optimal PEEPIND for this patient. The highest PEEP is limited to 20 cmH2O

Trial Locations (1)

31527

RECRUITING

Tanta University, Tanta

All Listed Sponsors
lead

Tanta University

OTHER