80
Participants
Start Date
November 5, 2023
Primary Completion Date
April 1, 2024
Study Completion Date
April 1, 2024
Positive end-expiratory pressure 5 (PEEP 5)
Fixed positive end-expiratory pressure of 5 cmH2O will be maintained throughout the duration of surgery
Individualized positive end-expiratory pressure (PEEPIND)
Patients will receive the individualized positive end-expiratory pressure. Titration process will be started after establishment of pneumoperitoneum: setting the initial PEEP to 5 cmH2O, then increasing positive end-expiratory pressure (PEEP)according to the gradient of 2 cmH2O every 3 min, calculating static compliance (Cstat) according to the formula: \[Cstat = VT/Pplat - PEEP\] (Pplat = plateau pressure), then gradually increasing positive end-expiratory pressure , until the calculated Cstat shows a downward trend, set its previous PEEP (corresponding to PEEP for high Cstat) as the optimal PEEPIND for this patient. The highest PEEP is limited to 20 cmH2O
RECRUITING
Tanta University, Tanta
Tanta University
OTHER