Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer in Adult Participants With a KRAS or NRAS Mutation

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

113

Participants

Timeline

Start Date

February 27, 2024

Primary Completion Date

November 30, 2026

Study Completion Date

January 31, 2027

Conditions
Metastatic Colorectal CancerCRCKRAS/NRAS Mutation
Interventions
DRUG

Onvansertib

Oral capsule

DRUG

FOLFIRI

FOLFIRI (irinotecan + fluorouracil \[5-FU\] + leucovorin) as intravenous (IV) infusion

DRUG

Bevacizumab

IV Infusion

DRUG

FOLFOX

FOLFOX (leucovorin + fluorouracil \[5-FU\] + oxaliplatin) as intravenous (IV) infusion

Trial Locations (41)

10016

Manhattan Hematology Oncology (MHO) Research Foundation, Inc., New York

18103

Lehigh Valley Health Network, Allentown

22031

Inova Schar Cancer Institute, Fairfax

22908

University of Virginia, Charlottesville

23298

VCU Massey Cancer Center, Richmond

32224

Mayo Clinic - Florida, Jacksonville

33021

Memorial Cancer Institute, Hollywood

34994

Cleveland Clinic Martin Health, Stuart

38138

West Cancer Clinic, Germantown

43210

The Ohio State University Wexner Medical Center, Columbus

44106

University Hospitals Cleveland Medical Center, Cleveland

44195

Cleveland Clinic, Cleveland

45242

Trihealth Kenwood, Cincinnati

46804

Fort Wayne Medical Oncology and Hematology, Fort Wayne

49503

Cancer & Hematology Centers of Western Michigan - Lemmen-Holton Cancer Pavilion, Grand Rapids

54911

ThedaCare Regional Cancer Center, Appleton

55905

Mayo Clinic Cancer Center, Rochester

63110

Washington University School of Medicine Center for Advanced Medicine, St Louis

64111

Saint Luke's Hospital, Kansas City

66205

The University of Kansas Cancer Center - Westwood, Westwood

67214

Cancer Center of Kansas, Wichita

72401

St. Bernards Medical Center, Jonesboro

72762

Highlands Oncology Group, Springdale

77024

Oncology Consultants, PA, Houston

77030

MD Anderson Cancer Center, Houston

84124

Utah Cancer Specialists, Salt Lake City

85054

Mayo Clinic - Arizona, Phoenix

85724

The University of Arizona Cancer Center, Tucson

89119

CCCN, Las Vegas

90089

Norris Comprehensive Cancer Center, Los Angeles

90095

UCLA Department of Medicine-Hematology/Oncology, Los Angeles

90505

Torrance Memorial Physician Network - Cancer Care and Infusion Center, Torrance

90602

PIH Health, Whittier

92037

UC San Diego Moores Cancer Center, La Jolla

92123

Sharp Memorial Hospital, San Diego

92708

Orange Coast Memorial Medical Center, Fountain Valley

92801

Pacific Cancer Medical Center, Anaheim

93309

Comprehensive Blood and Cancer Center - Bakersfield, Bakersfield

96819

Kaiser Permanente, Honolulu

97239

Oregon Health and Science University, Portland

98101

Virginia Mason Medical Center, Seattle

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

Cardiff Oncology

INDUSTRY