A Study to Learn About the Study Medicine Called PF-07220060 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

333

Participants

Timeline

Start Date

January 9, 2024

Primary Completion Date

September 26, 2025

Study Completion Date

January 21, 2028

Conditions
Advanced or Metastatic Breast Cancer
Interventions
DRUG

PF-07220060 CDK4 inhibitor

Experimental

DRUG

Fulvestrant

Experimental and Active comparator

DRUG

Everolimus

Active Comparator

DRUG

Exemestane

Active Comparator

Trial Locations (159)

112

Koo Foundation Sun Yat-Sen Cancer Center, Taipei

333

Chang Gung Medical Foundation-Linkou Branch, Taoyuan District

704

National Cheng Kung University Hospital, Tainan City

1019

Centro Medico Austral, Buenos Aires

1125

Fundación Cenit Para La Investigación En Neurociencias, CABA

2109

Macquarie University, North Ryde

4000

Centro Para la Atención Integral del Paciente Oncologico (CAIPO), San Miguel de Tucumán

Exelsus Oncología Clínica, San Miguel de Tucumán

4200

Sanatorio Norte, Santiago del Estero

4812

Icon Cancer Centre Townsville, Rosslea

5400

COE (Centro Oncológico de Excelencia), San Juan

10002

National Taiwan University Hospital, Taipei

10408

National Cancer Center, Goyang-si

10449

Mackay Memorial Hospital, Taipei

11217

Taipei Veterans General Hospital, Taipei

12601

Vassar Brothers Medical Center, Poughkeepsie

13620

Seoul National University Bundang Hospital, Seongnam

16499

Ajou University Hospital, Suwon

20007

Georgetown University Medical Center, Washington D.C.

20010

MedStar Washington Hospital Center, Washington D.C.

21200

Dicle Üniversitesi, Diyarbakır

31203

Unidad de Investigación en Salud de Chihuahua, S.C., Chihuahua City

34214

Medipol Mega Universite Hastanesi, Stanbul

34899

Marmara Universitesi Pendik Egitim Arastirma Hastanesi, Istanbul

35100

Ege Universitesi Hastanesi, Izmir

40447

China Medical University Hospital, Taichung

41380

Kocaeli Üniversitesi, Kocaeli

42080

Necmettin Erbakan Meram Medical Fac., Konya

42601

Keimyung University Dongsan Hospital, Daegu

44600

Boca Clinical Trials Mexico S.C., Guadajalara

49241

Pusan National University Hospital, Busan

52105

Aurora Health Center - Southern Lakes, Burlington

53024

Aurora Medical Centers - Grafton, Grafton

53066

Aurora Medical Center - Summit, Summit

53142

Aurora Health Center - Kenosha, Kenosha

53209

Aurora Health Center Milwaukee - Good Hope, Milwaukee

53215

Aurora St Luke's Medical Center, Milwaukee

53226

Aurora Cancer Care, Wauwatosa

54311

Aurora BayCare Medical Center, Green Bay

55200

Samsun Medical Park Hastanesi, Samsun

59101

Intermountain Health St. Vincent Regional Hospital, Billings

59102

Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana, Billings

60026

NorthShore University HealthSystem, Glenview

60035

NorthShore University HealthSystem, Highland Park

60201

NorthShore University HealthSystem, Evanston

60611

Northwestern Memorial Hospital, Chicago

60625

NorthShore University HealthSystem, Chicago

64460

Filios Alta Medicina S.A. de C.V., Monterrey

68000

Oaxaca Site Management Organization S.C., Oaxaca City

77030

Memorial Hermann Cancer Center, Houston

78665

Baylor Scott & White Medical Center - Round Rock, Round Rock

89511

Cancer Care Specialists, Reno

90033

Keck Hospital of USC, Los Angeles

Los Angeles General Medical Center, Los Angeles

USC/Norris Comprehensive Cancer Center, Los Angeles

91105

Keck Medical Center of USC Pasadena, Pasadena

91851

Instituto Veracruzano en Investigación Clínica S.C., Veracruz

92253

Eisenhower George and Julia Argyros Health Center, La Quinta

92262

Eisenhower Health Center at South Palm Canyon, Palm Springs

92270

Eisenhower Medical Center, Rancho Mirage

92618

Hoag Health Center Irvine, Irvine

Hoag Hospital Irvine, Irvine

92663

Hoag Memorial Hospital Presbyterian, Newport Beach

94110

Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco

94158

UCSF Medical Center at Mission Bay, San Francisco

94402

UCSF Cancer Center San Mateo, San Mateo

94538

Washington Hospital Healthcare System, Fremont

94702

UCSF - John Muir Health Cancer Center Berkeley, Berkeley

100021

Cancer Hospital Chinese Academy of Medical Science, Beijing

100142

Beijing Cancer hospital, Beijing

110000

The First Hospital of China Medical University, Shenyang

110085

Rajiv Gandhi Cancer Institute And Research Centre, New Delhi

130000

Jilin Province Tumor Hospital, Changchun

130021

The First Hospital of Jilin University, Changchun

150081

Harbin Medical University Cancer Hospital, Harbin

200032

Fudan University Shanghai Cancer Center, Shanghai

300060

Tianjin Medical University Cancer Institute & Hospital, Tianjin

310016

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

395004

Kiran Hospital - Multi Super Speciality Hospital and Research Center, Surat

400012

Tata Memorial Hospital, Mumbai

401107

Bhakti Vedanta Hospital and Research Institute, Thāne

410013

Hunan Cancer Hospital, Changsha

411004

Sahyadri Super Speciality Hospital, Pune

422009

Apex Wellness Hospital, Nashik

430030

Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan

440001

Kims Kingsway Hospital, Nagpur

450008

Henan Cancer Hospital, Zhengzhou

471003

The First Affiliated Hospital of Henan University of Science &Technology, Luoyang

510000

Guangdong Provincial People's Hospital, Guangzhou

528041

The First People's Hospital of Foshan, Foshan

530021

Guangxi Medical University Affiliated Tumor Hospital, Nanning

560069

Spandana Oncology Centre (SOC), Bangalore

610041

West China Hospital of Sichuan University, Chengdu

3109601

Rambam Health Care Campus, Haifa

4941492

Rabin Medical Center, Petah Tikva

9103102

Shaare Zedek Medical Center, Jerusalem

14784400

Fundação Pio XII - Hospital de Câncer de Barretos, Barretos

06606

Saint Vincent's Medical Center (SVMC), Bridgeport

06810

Danbury Hospital, Danbury

06102

Hartford Hospital (HH), Hartford

06451

MidState Medical Center (MMC), Meriden

06053

Hartford Healthcare, New Britain

06856

Norwalk Hospital, Norwalk

06062

Hartford HealthCare Cancer Institute at The Hospital of Central Connecticut, Medical Arts Center, Plainville

C1119ACN

CIPREC, Ciudad Autonoma de Buenos Aires

C1015ABO

Organizacion Medica de Investigacion, CABA

R8500ACE

Clinica Viedma S. A, Viedma

S2000KZE

Instituto de Oncología de Rosario, Rosario

C1056ABI

Centro de Investigaciones Metabólicas (CINME), Buenos Aires

X5004FHP

Clínica Universitaria Reina Fabiola, Córdoba

F5300COE

Fundación CORI para la Investigación y Prevención del Cáncer, La Rioja

50070-480

Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Pernambuco, Recife

Hospital Esperança Recife: Pronto Atendimento 24h, Pernambuco

59062-000

Liga Norte Riograndense Contra o Câncer, Natal

98700-000

ONCOSITE - Centro de Pesquisa Clinica em Oncologia, Ijuí

90610-000

Hospital São Lucas da PUCRS, Porto Alegre

09541-270

Centro de Oncologia - CEON+ - Unidade São Caetano do Sul, São Caetano do Sul

E3B 5N5

Dr. Everett Chalmers Regional Hospital, Fredericton

L4M 6M2

Royal Victoria Regional Health Centre, Barrie

G7H 5H6

CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi

H3T 1E2

Jewish General Hospital, Montreal

464-8681

Aichi Cancer Center Hospital, Nagoya

466-8560

Nagoya University Hospital, Nagoya

260-8717

Chiba cancer center, Chiba

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

373-8550

Gunma Prefectural Cancer Center, Otashi

003-0804

National Hospital Organization Hokkaido Cancer Center, Sapporo

980-8574

Tohoku University Hospital, Sendai

541-8567

Osaka International Cancer Institute, Osaka

565-0871

Osaka University Hospital, Suita

350-1298

Saitama Medical University International Medical Center, Hidaka

104-8560

St. Luke's International Hospital, Chuo-ku

135-8550

The Cancer Institute Hospital of JFCR, Koto

730-8518

Hiroshima City Hiroshima Citizens Hospital, Hiroshima

700-8558

Okayama University Hospital, Okayama

540-0006

National Hospital Organization Osaka National Hospital, Osaka

06100

Cryptex Investigación Clínica S.A. de C.V., Cuauhtémoc

03100

Mexico Centre for Clinical Research S.A de C.V, Mexico City

04700

COI Centro Oncologico Internacional S.A.P.I. de C.V., Mexico City

03080

Seoul National University Hospital, Seoul

03181

Kangbuk Samsung Hospital, Seoul

05505

Asan Medical Center, Seoul

06273

Gangnam Severance Hospital, Yonsei University Health System, Seoul

06351

Samsung Medical Center, Seoul

08308

Korea University Guro Hospital, Seoul

Unknown

Acibadem Altunizade Hospital, Üsküdar / Stanbul

Ultramar Medical Imaging Center, Ankara

Erciyes Universitesi Tıp Fakultesi Hastaneleri, Kayseri

06010

Gulhane Egitim Arastirma Hastanesi, Ankara

06200

Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi, Ankara

06230

Hacettepe Universite Hastaneleri, Ankara

06420

Ultramar Medical Imaging Center, Ankara

06520

Memorial Ankara Hastanesi, Ankara

06530

Ultramar Medical Imaging Center, Ankara

06800

Ankara Bilkent Şehir Hastanesi, Ankara

W6 8RF

Imperial College Healthcare NHS Trust, Charing Cross Hospital, London

w1g 6ad

Sarah Cannon Research Institute UK, London

GU2 7XX

The Royal Surrey County Hospital, Guildford

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY