Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

NARecruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

December 5, 2024

Primary Completion Date

August 31, 2028

Study Completion Date

August 31, 2028

Conditions
Appetitive BehaviorObesity
Interventions
DEVICE

Repetitive Transcranial Magnetic Stimulation (rTMS)

"rTMS is a technique of TMS that allows for selective external manipulation of neural activity in a non-invasive manner. During rTMS a rapidly changing current is passed through an insulated coil placed against the scalp. This generates a temporary magnetic field, which in turn induces electrical current in neurons and allows for modulation of neural circuitry.~Intermittent theta burst stimulation (iTBS) consisting of 2 s trains of 3 pulses at 50 Hz, repeated at 5 Hz, every 10s for a total of 600 pulses (82), will be applied to the target. Cerebellar stimulation will be applied to the targets at 100% of aMT or 35% maximal stimulator output, whichever is higher."

DEVICE

Sham repetitive Transcranial Magnetic Stimulation (rTMS)

"rTMS is a technique of TMS that allows for selective external manipulation of neural activity in a non-invasive manner. During rTMS a rapidly changing current is passed through an insulated coil placed against the scalp. This generates a temporary magnetic field, which in turn induces electrical current in neurons and allows for modulation of neural circuitry.~Intermittent theta burst stimulation (iTBS) consisting of 2 s trains of 3 pulses at 50 Hz, repeated at 5 Hz, every 10s for a total of 600 pulses (82), will be applied to the target. Cerebellar stimulation will be applied to the targets at 100% of aMT or 35% maximal stimulator output, whichever is higher.~Sham is achieved by using a coil with a magnetic shield preventing magnetic field from reaching the head."

Trial Locations (2)

02478

RECRUITING

McLean Hospital, Belmont

02120

RECRUITING

Brigham and Women's Hospital, Boston

All Listed Sponsors
collaborator

Mclean Hospital

OTHER

collaborator

Beth Israel Deaconess Medical Center

OTHER

lead

Brigham and Women's Hospital

OTHER