1,806
Participants
Start Date
December 11, 2023
Primary Completion Date
June 1, 2027
Study Completion Date
September 1, 2027
Intraoperative ventilation with individualized high PEEP titrated to the lowest ΔP with RMs
The intervention is intraoperative ventilation using the available ventilator with individualized high PEEP titrated to the lowest ΔP with RMs. After abdominal insufflation, patients randomized to the individualized high PEEP with RMs group will receive a RM followed by a 'decremental PEEP trial'. This is followed by a second RM after which PEEP is set at the level indicated by the decremental PEEP trial
RECRUITING
Amsterdam University Medical Center, Amsterdam
Onze Lieve Vrouwe Gasthuis
OTHER
HagaZiekenhuis
OTHER
Dijklander Ziekenhuis
OTHER
The Netherlands Cancer Institute
OTHER
Isala
OTHER
Maasstad Hospital
OTHER
Medisch Spectrum Twente
OTHER
University Medical Center Groningen
OTHER
Leiden University Medical Center
OTHER
Hospital Universitario La Fe
OTHER
Ospedale Policlinico San Martino
OTHER
University Hospital Carl Gustav Carus
OTHER
Medical University Innsbruck
OTHER
Spaarne Gasthuis
OTHER
Zaans Medical Center
OTHER
Alrijne Hospital
OTHER
Albert Schweitzer Hospital
OTHER
Maastricht University Medical Center
OTHER
Noordwest Ziekenhuisgroep
OTHER
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
OTHER