Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girls

NARecruitingINTERVENTIONAL
Enrollment

474

Participants

Timeline

Start Date

September 6, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Folate DeficiencyVitamin B 12 DeficiencyAnemia, MegaloblasticCognitive DevelopmentDepressive Symptoms
Interventions
DIETARY_SUPPLEMENT

Folic acid and vitamin B12 fortified flour

Standard bags of fortified cereal-based flours will be prepared at local mills from the common staple cereal food in the area. The dose of vitamins will be added to the flour of the intervention group and mixed with batch mixing technique. The concentration of folic acid and vitamin B12 per 1kg of flour will be 2mg and 0.02mg, respectively. Participants will be supplied with 6 kg bags of flour, which will be enough for 30 days, and 1.5kg bags of flour will be delivered to their home on a weekly basis and lasting for 6 months. Instructions on the preparation of meals and frequency of intake with a weekly compliance sheet will be provided for monitoring the intervention.

OTHER

Unfortified cereal flour

Standard bags of unfortified cereal-based flours will be prepared at local mills from the common staple cereal food in the area. Participants will be supplied with 6 kg bags of flour, which will be enough for 30 days, and 1.5kg bags of flour will be delivered to their home on a weekly basis and lasting for 6 months. Instructions on the preparation of meals and frequency of intake with a weekly compliance sheet will be provided for monitoring the intervention.

Trial Locations (2)

21

RECRUITING

Arba Minch Health and Demographic Surveillance System sites, Arba Minch

Unknown

NOT_YET_RECRUITING

Arba Minch University, Arba Minch

All Listed Sponsors
collaborator

Arba Minch University

OTHER

collaborator

Institut de Recherche en Sciences de la Sante, Burkina Faso

OTHER_GOV

collaborator

Addis Ababa University

OTHER

lead

University Ghent

OTHER