Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE)

PHASE4RecruitingINTERVENTIONAL
Enrollment

8,600

Participants

Timeline

Start Date

January 3, 2024

Primary Completion Date

January 31, 2029

Study Completion Date

July 31, 2029

Conditions
Obesity
Interventions
DRUG

Naltrexone-Bupropion (NB) Combination

A total daily dosage of two NB 8 mg/90 mg tablets twice daily (32 mg/360 mg) is reached at the start of Week 4.

DRUG

Placebo

A total daily dosage of two placebo tablets twice daily (in an identical, non-medicine containing tablet) is reached at the start of Week 4.

Trial Locations (138)

10017

TERMINATED

Synexus Clinical Research US, Inc. - New York, New York

13850

TERMINATED

Velocity Clinical Research, Vestal

13905

RECRUITING

Velocity Clinical Research, Binghamton

19044

RECRUITING

Hatboro Medical Associates/Avacare Research, Horsham

19111

TERMINATED

Mercado Medical Practice/CCT Research, Philadelphia

20850

RECRUITING

Advanced Primary Care & Geriatrics/CCT Research, Rockville

20852

TERMINATED

Regenerative Orthopedics and Sports Medicine- NextStage Clinical Research, North Bethesda

20854

RECRUITING

Velocity Clinical Research, Rockville, Rockville

22911

RECRUITING

Charlottesville Medical Research, Charlottesville

23435

RECRUITING

Velocity Clinical Research, Suffolk, VA, Suffolk

23502

RECRUITING

AMR Norfolk, Norfolk

23666

RECRUITING

Velocity Clinical Research, Hampton, Hampton

27701

RECRUITING

Velocity Clinical Research, Durham, Durham

29204

RECRUITING

Velocity Clinical Research, Columbia

29303

RECRUITING

Velocity Clinical Research, Spartanburg, Spartanburg

29340

RECRUITING

Velocity Clinical Research, Gaffney

29379

RECRUITING

Velocity Clinical Research, Union, Union

29405

RECRUITING

Coastal Carolina Research Center, North Charleston

29414

TERMINATED

Velocity Clinical Research, Charleston

29615

TERMINATED

Velocity Clinical Research, Greenville

29621

RECRUITING

Velocity Clinical Research, Anderson

30030

RECRUITING

Accel Research Sites (ARSN) - Neurostudies, Decatur

30309

RECRUITING

Advanced Clinical Research Atlanta, Atlanta

31406

RECRUITING

Velocity Clinical Research, Savannah, Savannah

31904

RECRUITING

Clincept Clinical Research, Columbus

32132

TERMINATED

Accel Research Sites Network - Edgewater, Edgewater

RECRUITING

Velocity Clinical Research (New Smyrna Beach), Edgewater

32162

RECRUITING

Synexus Clinical Research US, Inc. - The Villages, The Villages

32168

RECRUITING

Healix Clinical Research, New Smyrna Beach

32934

RECRUITING

Optimal Research, LLC. - Melbourne, Melbourne

33010

ACTIVE_NOT_RECRUITING

G+C Research Group, Hialeah

RECRUITING

Qway Research, Hialeah

33013

RECRUITING

Conveinent Medical Research, Hialeah

33024

RECRUITING

Best Choice Medical and Research Services, Pembroke Pines

33027

RECRUITING

Innovia Research Center, Miramar

33028

RECRUITING

Bolanos Clnical Research, Pembroke Pines

33063

NOT_YET_RECRUITING

D&H Pompano Research Center, LLC, Margate

33122

RECRUITING

D&H Doral Research Center, Doral

33134

RECRUITING

LMG Research, Coral Gables

33141

RECRUITING

Miami Beach Clinical Research, Miami Beach

33156

RECRUITING

Advanced Clinical Research, Miami

33157

RECRUITING

IMRC At Palmetto Bay, Palmetto Bay

33165

RECRUITING

Medical Research Center Westchester, Miami

33169

RECRUITING

Biscayne Clinical Research Inc, North Miami

33173

ACTIVE_NOT_RECRUITING

Century Research, Miami

RECRUITING

ITB Research, Miami

33176

RECRUITING

Entrust Clinical Research, Miami

RECRUITING

New Horizons Research, Palmetto Bay

33182

RECRUITING

Cordova Research Institute, Sweetwater

33186

RECRUITING

Janus Clinical Research, Miami

33189

RECRUITING

JY Research Institute, Cutler Bay

33316

RECRUITING

IMRC Fort Lauderdale, Fort Lauderdale

33321

NOT_YET_RECRUITING

D&H Tamarac Research Center, LLC, Tamarac

33445

RECRUITING

Delray Physician Center, Delray Beach

33461

RECRUITING

Altus Research, Lake Worth

33907

RECRUITING

Southwest General Healthcare Center, Fort Myers

33914

ACTIVE_NOT_RECRUITING

ABMED Clinical Research, Cape Coral

34744

RECRUITING

Ilumina Medical Research, Kissimmee

35055

TERMINATED

Cullman Clinical Trials, Cullman

35216

RECRUITING

Accel Research Sites Network, Birmingham

36608

RECRUITING

AMR Mobile, Mobile

RECRUITING

Velocity Clinical Research, Mobile, Mobile

39503

RECRUITING

Velocity Clinical Research, Gulfport

44122

RECRUITING

Velocity Clinical Research, Beachwood

45219

RECRUITING

Velocity Clinical Research, Mt. Auburn, Cincinnati

45242

RECRUITING

Velocity Clinical Research, Cincinnati, Cincinnati

45246

RECRUITING

Velocity Clinical Research, Cincinnati

45801

RECRUITING

NexGen Research, Lima

46383

RECRUITING

Velocity Clinical Research, Valparaiso

46410

RECRUITING

Indiana Medical Research Institute, Merriville

48126

TERMINATED

Dearborn Cardiology, Dearborn

51106

RECRUITING

Velocity Clinical Research, Sioux City

54701

ACTIVE_NOT_RECRUITING

Evergreen Surgical, Eau Claire

60073

TERMINATED

JAELEX Research, Round Lake Beach

60137

TERMINATED

NextStage Clinical Research-Chicago, Glen Ellyn

63119

RECRUITING

St. Louis Medical Professionals/CCT Research, St Louis

64151

RECRUITING

Clay Platte Family Medicine, Kansas City

66210

TERMINATED

Velocity Clinical Research, Kansas City, Kansas City

67042

RECRUITING

AMR - El Dorado, El Dorado

67205

TERMINATED

AMR Wichita West, Wichita

67207

RECRUITING

AMR Wichita East, Wichita

67214

RECRUITING

Wichita Surgical Specialists, Wichita

68134

RECRUITING

Meridian Clinical Research - Velocity, Omaha

68144

TERMINATED

Midwest Regional Health Services, Omaha

68506

TERMINATED

Velocity Clinical Research at Pioneer Heart Institute, Lincoln

68510

RECRUITING

Velocity Clinical Research, Lincoln

68701

RECRUITING

Velocity Clinical Research, Norfolk, Norfolk

68803

RECRUITING

Velocity Clinical Research, Grand Island, Grand Island

70119

TERMINATED

AMR New Orleans, New Orleans

RECRUITING

Velocity Clinical Research, New Orleans, New Orleans

70433

RECRUITING

Velocity Clinical Research, Covington

70458

TERMINATED

Velocity Clinical Research, Slidell

70508

RECRUITING

Velocity Clinical Research, Lafayette

70809

RECRUITING

Velocity Clinical Research, Baton Rouge

74136

RECRUITING

NextStage Clinical Research - Tulsa, Tulsa

76712

RECRUITING

Waco Cardiology Consultants, Waco

77022

RECRUITING

HDH Research, Houston

77058

RECRUITING

All-American Orthopedics-NextStage Clinical Research, Houston

77479

RECRUITING

Olympus Clinical Research, Sugarland

77642

RECRUITING

NextStage Clinical Research-Port Arthur/Gulf Coast Cardiology, Port Arthur

77702

RECRUITING

Advanced Cardiovascular Specialists/NextStage Clinical Research, Beaumont

78229

NOT_YET_RECRUITING

Synexus Clinical Research US; Inc., San Antonio

78705

RECRUITING

Optimal Research, LLC. - Austin, Austin

78759

RECRUITING

Velocity Clinical Research, Austin

79410

TERMINATED

NextStage Clinical Research-Lubbock/SWAT Surgical Associates-NextStage Clinical Research, Lubbock

79606

RECRUITING

Velocity Clinical Research, Abilene, Abilene

80110

RECRUITING

Velocity Clinical Research, Denver, Englewood

84088

RECRUITING

Velocity Clinical Research, Salt Lake City, West Jordan

85006

RECRUITING

Velocity Clinical Research, Phoenix, Phoenix

85213

RECRUITING

Desert Clinical Research, Mesa

85283

RECRUITING

Fiel Family & Sports Medicine CCT Research, Tempe

85304

RECRUITING

Sun City Research, Glendale

85306

ACTIVE_NOT_RECRUITING

Cardiovascular Consultants/NextStage Clinical Research, Glendale

85741

NOT_YET_RECRUITING

Synexus Clinical Research US; Inc., Tucson

87107

RECRUITING

Velocity Clinical Research, Albuquerque

87505

TERMINATED

Axces Research Group, Santa Fe

89102

RECRUITING

Avacare, Las Vegas

89119

TERMINATED

Santa Rosa Urgent Care Primary Care/CCT Research, Las Vegas

RECRUITING

Las Vegas Clinical Trials, North Las Vegas

90057

TERMINATED

Velocity Clinical Research, Los Angeles

90247

RECRUITING

Velocity Clinical Research, Gardena, Anderson

90255

RECRUITING

Velocity Clinical Research, Huntington Park, Huntington Park

90806

ACTIVE_NOT_RECRUITING

Long Beach Clinical Trials, Long Beach

91405

TERMINATED

Velocity Clinical Research, Van Nuys, Van Nuys

91768

ACTIVE_NOT_RECRUITING

National Institute of Clinical Research, Inc., Pomona

91790

RECRUITING

Providere Research, West Covina

91911

RECRUITING

Velocity Clinical Research, Chula Vista

91942

RECRUITING

Velocity Clinical Research, San Diego, La Mesa

92408

RECRUITING

Velocity Clinical Research, San Bernardino, San Bernardino

92704

TERMINATED

Velocity Clinical Research at Coastal Heart Medical Group, Santa Ana

TERMINATED

Velocity Clinical Research of Santa Ana, Santa Ana

93534

RECRUITING

Chemidox Clinical Trials Inc., Lancaster

95350

RECRUITING

Valley Vitality Ventures, Manteca

97504

RECRUITING

Velocity Clinical Research, Medford, Medford

97527

TERMINATED

Velocity Clinical Research, Grants Pass, Grants Pass

01844

RECRUITING

Activmed Practices and Research, Inc, Methuen

03801

RECRUITING

ActivMed Practices and Research, Portsmouth

02818

RECRUITING

Velocity Clinical Research (Providence), East Greenwich

Sponsors
All Listed Sponsors
lead

Currax Pharmaceuticals

INDUSTRY