Usage of 5-fluorouracil and Carnoy's Solution in Surgical Treatment of Odontogenic Keratocysts

PHASE4Enrolling by invitationINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

June 10, 2023

Primary Completion Date

June 10, 2025

Study Completion Date

June 10, 2028

Conditions
Odontogenic Keratocyst
Interventions
PROCEDURE

Enucleation

Enucleation is complete removal of the cyst from the bony defect of the jaw affected by the lesion. Osteotomy is performed to allow access to the cyst, cystic wall is detached from the bone and removed completely.

DIAGNOSTIC_TEST

incisional biopsy

Lesions clinically abd radiographically consistent with OKC will be submitted for histological examination to confirm the diagnosis of OKC

DRUG

Application of 5-fluorouracil

5% 5-fluorouracil cream will be applied immediately after the enucleation to the cystic cavity for 24 hours

DRUG

Application of Carnoy solution

Carnoy solution will be applied during the enucleation as described previously

Trial Locations (1)

11000

School of Dental Medicine, Belgrade

All Listed Sponsors
lead

University of Belgrade

OTHER